ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
KL28. Polytopic Metal Complexes With 2, 6-Di-Tert-Butylphenol Pendants
In Cellular Oxidation Processes
E. Milaeva a , D. Shpakovsky a , Z. Jingwei a , S. Filimonova a , E. Shevtsova a , S. Bachurin b ,
N. Zefirov a
a Organic Chemistry, Moscow State Lomonosov University, Lenin Hills, 119992, Moscow, Russia,
b Neurochemistry of Physiologically Active Compounds, Institute of Physiologically Active Compounds of R,
Severnyi proezd, 142432, Chernogolovka, Russia
e-mail: milaeva@org.chem.msu.ru
The polytopic biometal complexes Rn[L]M (M = Fe, Mn, Co, Cu, Zn) with various chelating ligands L bearing
2, 6-di-tert-butylphenol groups R as antioxidant fragments were synthesized (Fig.). The physico-chemical
properties of the compounds and the characteristics of phenoxyl radicals formed in the oxidation of Rn[L]M
have been studied [1-4].
The antioxidative activity of Rn[L]M has been studied in cellular oxidation processes using the lipid
peroxidation (1) in vitro in intact mitochondria isolated from rat liver, (2) in vitro in rat and fish liver
homogenates, (3) in the model reactions of (Z)-octadec-9-enic acid peroxidation, and of DPPH reduction. The in
vivo study has been performed for the most active compounds using fish organism (Asipenser gueldenstaedti
B.).
The results suggest that Rn[L]M are membrane active compounds and might be studied in an effort to find novel
protectors of oxidative stress.
The financial support of RFBR (08-03-00844, 07-03-00751, 07-03-12110, 06-03-32773), the Program
"Biomolecular and Medicinal Chemistry" of Russian Academy of Sciences is gratefully acknowledged.
References:
[1] Milaeva E., Gerasimova O., Jingwei Zh., Shpakovsky D., Shevtsova E., Bachurin S., Zefirov N. J. Inorg.
Biochem., 2008, 102, 1348-1358.
[2] Milaeva E. J. Inorg. Biochem., 2006, 100, 905-915.
[3] Milaeva E., Tyurin V., Shpakovsky D., Gerasimova O., Jingwei Zh., Gracheva Yu. Heteroatom Chemistry,
2006, 17, 475.
[4] Milaeva E., Shpakovsky D., Tyurin V. J. Porphyrins & Phthalocyan., 2003, 8, 701.
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