ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
P23. Synthesis, X-ray Structure of New Pt(II), Pd(II) and Cu(II) Complexes
with 5-amino-8-methyl-chromone
E. Budzisz a , I. P. Lorenz b , P. Mayer b , A. Jozwiak c
a
Department of Cosmetic Raw Materials Chemistry, Medical University of Lodz, Muszynskiego 1, 90-151, Lodz,
Poland
e-mail: elora@ich.pharm.am.lodz.pl
b
Department of Chemistry and Biochemistry, Ludwig Maximilian University, Butenandtstr. 5-12 (D), D-81377,
Munich, Germany
c
Department of Organic Chemistry, University of Lodz, Narutowicza 68, 90-136, Lodz, Poland
The metal complexes which contain chromone derivatives as a ligand show anticoagulant properties [1, 2] and
antitumor activity. [3, 4] In particular, complexes with palladium(II), copper(II), and platinium(II), exhibit
pronounced in vitro cytotoxicity. [5, 6]
In this study, we present the synthesis and characterization of metal complexes of 5-amino-8-methyl-chromone.
Elemental analysis, FT-IR, UV-Vis spectroscopy and X-ray crystallography have been used to characterize the
complexes.
Acknowledgements. Financial support from Medical University of Lodz (grant No 503-3066-2).
References:
[1] Jiang, D.; Deng, R.; Wu, J., Wuji Huaxue, 1989, 5, 21-28.
[2] Deng, R.; Wu, J.; Long, L., Bull. Soc. Chim. Belg., 1992, 101, 439-443
[3] Kostova, I.; Manolov, I.; Konstantinov, S.; Karaivanova, M., Eur. J. Med. Chem., 1999, 34, 63-68.
[4] Manolov, I.; Kostova, I.; Netzeva, T.; Konstantinov, S.; Karaivanova, M., Arch. Pharm. Pharm. Med. Chem.,
2000, 333, 93-98.
[5] E. Budzisz, M. Malecka, I-P. Lorenz, P. Mayer, R. Kwiecień, P. Paneth, U. Krajewska, M. Rozalski, Inorg.
Chem., 2006, 45(24), 9688-9695.
[6] E. Budzisz, M. Malecka B. Keppler V.B. Arion, G.Andrijewski, U. Krajewska, M. Różalski, Eur. J.
Inorg.Chem., 2007, 3728-3735.
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