ISBN: 978-83-60043-10-3 - eurobic9

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Eurobic9, 2-6 September, 2008, Wrocław, Poland G. Knör SL16. Potential Applications of Multifunctional Coordination Compounds in Molecular Photomedicine Institute of Inorganic Chemistry, Johannes Kepler University Linz (JKU), Altenbergerstrasse 69, A-4040 Linz, Austria e-mail: Guenther.Knoer@JKU.at Fundamental research on the photochemical and photophysical properties of coordination compounds frequently leads to important innovations in the field of modern life sciences. In this context, the application of luminescent and light-responsive metal complexes as probes, labels or diagnostic tools, and the interaction of photosensitizers with biological systems in general has been widely studied. Photoreactive metal complexes have also been applied successfully in the context of biomimetic and bio-inspired systems, including artificial enzyme catalysis, which has been demonstrated to compete very well with the performance of native biocatalysts [1]. More recently, the potential use of photoreactive coordination compounds for the controlled release of drugs and therapeutic agents has also been taken into consideration [2-4]. In the present contribution, some novel aspects of light-sensitive multichromophore systems and photoreactive metal complexes will be discussed in the context of molecular photomedicine. These examples include artificial photonuclease enzymes and systems for the photoinduced release of small bioactive compounds. Acknowledgement: The DFG Graduate College 640 “Sensory Photoreceptors in Natural and Artificial Systems” is gratefully acknowledged for financial support. References: [1] G. Knör, Bionic Catalyst Design: A Photochemical Approach to Artificial Enzyme Function, ChemBioChem 2001, 2, 593-596. [2] F. S. Mackay, J. A. Woods, P. Heringová, J. Kašpárková, A. M. Pizarro, S. A. Moggach, S. Parsons, V. Brabec, P. J. Sadler, A Potent Cytotoxic Photoactivated Platinum Complex, PNAS 2007, 104, 20743-20748. [3] K. Szacilowski, W. Macyk, A. Drzewiecka-Matuuszek, M. Brindell, G. Stochel, Bioinorganic Photochemistry: Frontiers and Mechanisms, Chem. Rev.2005, 105, 2647-2694. [4] G. Knör, Artificial Enzyme Catalysis Controlled and Driven by Light, Chem. Eur. J. 2008, submitted for publication. _____________________________________________________________________ 68
Eurobic9, 2-6 September, 2008, Wrocław, Poland SL17. Light and Inorganic Species in Nanomedicine W. Macyk, K. Szaciłowski, M. Brindell, A. Jańczyk, P. Łabuz, G. Stochel Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060, Kraków, Poland, e-mail: stochel@chemia.uj.edu.pl Nanomedicine, the application of nanotechnology and nanomaterials in healthcare, offers numerous very promising possibilities to significantly improve medical diagnosis and therapy, leading to higher quality of life. Excited states of metal complexes and nanocrystalline wide bandgap semiconductors offer new physicochemical properties which can be used for medical purposes. Depending on the type of excited state and its deactivation pathway (radiative or nonradiative, energy or electron transfer, direct or sensitised process) inorganic or hybrid (inorganic-organic) nanomaterials can be considered for diagnostic, preventive or therapetic applications.[1] In this contribution some examples from our latest studies focused on new nanomaterials or strategies for photomedicine (photodynamic therapy PDT, photodynamic inactivation PDI, photochemiotherapy, photodiagnosis, phototargeting etc.) will be presented.[2-4] References: [1] K. Szaciłowski, W. Macyk, A. Drzewiecka-Matuszek, M. Brindell and G. Stochel, Chem. Rev., 105, 2647- 2694 (2005). [2] A. Jańczyk, A. Wolnicka-Głubisz, K. Urbanska, H. Kisch, G. Stochel, W. Macyk, Free Rad. Biol. Med., 44 (2008) 1120-1130. [3] D. Mitoraj, A. Jańczyk, M. Strus, H. Kisch, G. Stochel, P.B. Heczko, W. Macyk, Photochem.Photobiol. Sci., 6 (2007), 642-648. [4]M. Brindell, E. Kuliś, S.K.C. Elmroth, K. Urbanska, G. Stochel, J. Med. Chem., 48, (2005) 7298 - 7304 _____________________________________________________________________ 69
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ISBN: 978-83-60043-10-3 - eurobic9

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