ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
P137. Synthesis of New Oxo-vanadium(IV) Coordination Compounds and
Evaluation of Their Insulin Mimetic Actvity
J. Nilsson, a M. Haukka, b E. Degerman, c D. Rehder, d E. Nordlander a
a Inorganic Chemistry Research Group, Chemical Physics, Center for Chemistry and Chemical Engineering,
Lund University, Getingevägen 6, SE-22100 Lund, Sweden
email: jessica.nilsson@chemphys.lu.se
b Department of Chemistry, University of Joensuu, Box 111, FI-80101 Joensuu, Finland
c Department of Experimental Medical Science, Biomedical Center, Lund University, SE-221 48 Lund, Sweden
d Institut für Anorganische und Angewandte Chemie, Universität Hamburg, Martin-Luther-King-Platz 6, D-
20146 Hamburg, Germany
With the intention of preparing new insulin mimetic compounds, two new V(IV) oxo complexes of the
tetradentate ligand N-(2-hydroxybenzyl)-N, N-bis(2-pyridylmethyl)amine, L, (Figure 1a) have been prepared and
characterized by NMR and IR spectroscopy, mass spectrometry, elemental analysis and X-ray diffraction. In
vitro effects on the insulin signaling pathways of the new complexes [V IV O(HSO4)(L)] (Figure 1b) and
[V IV O(Cl2)(L)] . MeOH as well as of a related V(IV) oxo complex of trispyridylmethylamine [1] have been
investigated. Neither of the complexes did, however, show the insulin mimetic effect observed for VOSO4 or
Na3VO4 salts. In fact this type of tetradentate coordinating ligands seems to inhibit the inherent insulin mimetic
effect of vanadium. To investigate this further we are now in the process of developing complexes containing
derivates of the original ligand, altering the coordination mode as well as the hydro/lipophilicity.
N
a) b)
N
Figure 1. a) The ligand, N-(2-hydroxybenzyl)-N, N-bis(2-pyridylmethyl)amine, used for synthesis of the new
complexes, one of which is b) [V IV O(HSO4)(L)].
Acknowledgements: The authors would like to thank The Research School in Pharmaceutical Science (FLÄK),
The Swedish Foundation for International Cooperation in Research and Higher education (STINT), The
European Cooperation in the Field of Scientific and Technical Research (COST Action D21) and The Royal
Physiographic Society in Lund for financial support.
Reference:
[1] Y. Tajika, K. Tsuge and Y. Sasaki, Dalton Trans., 1438 (2005)
_____________________________________________________________________
256
OH
N