ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
SL34. Biochemical and Medicinal Application of Cage Transition
Metal Complexes
Yan Z. Voloshin, a Oleg A. Varzatskii, b Yurii N.Bubnov а
a
N.A.Nesmeyanov Institute of Organoelement Compounds RAS, 119991 Moscow, Russia
e-mail: voloshin@ineos.ac.ru
b
V.I.Vernadskii Institute of General and Inorganic Chemistry NANU, 03680 Kiev, Ukraine.
The following main trends and the perspectives of practical application of the transition metal clathrochelates in
biochemistry and medicine - encapsulation of radioactive metal ion for diagnostics and therapy; detoxifying
biological systems and prolonged pharmaceuticals; pharmaceuticals for boron-neutron capture therapy;
antioxidants; membrane transport of the metal ions; interaction of the cage metal complexes with nucleic acids
and the potential of their self-assembling reactions in immunology and molecular biology (recognition of
antibodies, antigens and the DNA sites); design of HIV inhibitors for the therapy - will be discussed.
substratum
substratum
linker
linker
linker B(OH) 2
H
O
N
N
O
H
linker
_____________________________________________________________________
86
H
O
N
N
O
H
HO
N N O H
Fe 2+
RB(OH) 2
substratum
B(OH) 2
= flourescent substituent
R = functionalizing substituent
substratum linker
N
Fe
N
2+
Y
O O
N
O
O
N N
O
Y O
R R
N R
R R R
N
Fe
N
2+
O
B
O O
N
N N
O
O
B O
R
N
R
substratum
lin
ker
N
Fe
N
2+
B
O O
N
O
O
N N
O
B O
R R
N R
R R R
lin
ker
substratum
Y = H, SbEt 3
Acknowledgement: This work was supported by RFBR (№06-03-32626, 07-03-12183 and 07-03-12144).
References:
[1] Y.Z.Voloshin, N.A.Kostromina, R.Krämer, Clathrochelates: synthesis, structure and properties, Elsevier,
Amsterdam, 2002.
[2] A.Mokhir, R.Krämer, Y.Z.Voloshin, O.A.Varzatskii, Bioorg.Med.Chem.Lett., 14, 2927 (2004).
[3] Y.Z.Voloshin, O.A.Varzatskii et al., Inorg. Chem., 44, 822 (2005); 47, 2155 (2008); Inorg.Chim.Acta, 360,
1543 (2007); Russ.Chem.Bull., Int.Ed., 55, 22 (2006); Angew.Chem.Int. Ed., 44, 3400 (2005); Polyhedron, 26,
2733 (2007); 27, 325 (2008).
[4] Y.Z.Voloshin, O.A.Varzatskii, Y.N.Bubnov, Russ.Chem.Bull., Int.Ed., 56, 579 (2007) (a review).