ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
P158. Zn Complexes of Oxolinic Acid: Structure and DNA-binding
Properties
G. Psomas a , A. Tarushi a , C. Raptopoulou b , D. P. Kessissoglou a
a
Department of General and Inorganic Chemistry, Fac, Aristotle University of Thessaloniki, P.O. Box 135,
GR-54124, Thessaloniki, Greece,
b
Institute of Materials Science, NCSR “Demokritos”, , GR-15310, Aghia Paraskevi Attikis, Greece
e-mail: gepsomas@chem.auth.gr
Zinc is an element of great biological interest. It is critical for numerous cell processes and is a major regulatory
ion in the metabolism of cells. In the literature, diverse zinc complexes with antidiabetic, antifungal,
antimicrobial, anti-inflammatory, antitumor and antiulcer activity are reported.
Quinolones (quinolonecarboxylic acids or 4–quinolones) are a group of synthetic antibacterial agents that
effectively inhibit DNA replication and are commonly used as treatment for many infections[1]. Oxolinic acid
(=Hoxo), a first–generation quinolone antimicrobial drug, is known for the treatment of urinary tract infections.
Although its pharmaceutical role is known for the last four decades, only one crystal structure of its complexes
has been reported [2].
Here we report the synthesis, the structure and DNA binding properties of the neutral mononuclear zinc
complexes with oxolinic acid in the absence or presence of the N-donor heterocyclic ligands pyridine (=py), 2,
2’-bipyridine (=bipy) and 1, 10-phenanthroline (=phen). The complexes Zn(oxo)2(H2O)2, Zn(oxo)2(py)2,
Zn(oxo)(bipy)Cl, Zn(oxo)(phen)Cl, Zn(oxo)2(bipy) and Zn(oxo)2(phen) (Figure 1) have been isolated and
spectroscopically and structurally characterized. The interaction of the complexes with CT DNA has been
investigated with UV and fluorescence spectroscopies in order to determine the intrinsic binding constants of the
complexes with DNA, the mode of binding and its correlation with the structure of the complexes.
References:
[1] I. Turel, Coord. Chem. Rev. 232 (2002) 27–47.
[2] G. Psomas, A. Tarushi, E.K. Efthimiadou, Y. Sanakis, C.P. Raptopoulou, N. Katsaros, J. Inorg. Biochem.
100 (2006) 1764–1773.
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