ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
P184. The Bioinspired Direct Synthesis of New Copper(II) Complex with
alfa – alaninehydroxamic Acid. Magnetic and Spectroscopic Properties
J. Sowińska, W. Wojciechowski, U. Oleksińska
Department of Chemistry, Wroclaw University of Technology, Wybrzeże Wyspinskiego 27, 50 - 370, Wroclaw,
Poland
e-mail: jolanta.sowinska@pwr.wroc.pl
Construction of chloride-bridged transition metal complexes is a productive research field, allowing to obtain
compounds with a quite wide range of applications and attractive frameworks, for example as chelating resin.
Hydroxamates and corresponding transition-metal complexes have been widely reported to exhibit antitumor,
antifungal and antibacterial properties – amongst several other biological activities[1]. The new polynuclear
copper(II) cluster with alfa-alaninehydroxamic acid of formula [Cu6(alfa-alaha)5Cl2.5]2 * 2HCl * 18H2O, where
alfa - alaha stands for alfa - alaninehydroxamate (C3H6N2O2 -2 ), was obtained. Crystal powder of the complex
was growing up in water solution. The cluster is composed of two hexanuclear subunits connected by five
chloride bridges . The characterization of this complex was based on elementary analysis, atomic absorption,
IR- and EPR-spectroscopy and magnetic measurements. Magnetic studies allowed to describe the shown spin
correlation within hexanuclear clusters and interaction between them. Spectroscopic behavior was studied at the
range of 4 – 300 K. Basing on computational calculations we try to predict antitumor properties.
References:
[1] H. Kehl, Chemistry and Biology of Hydroxamic Acids, Karger, New York, 1982.
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