ISBN: 978-83-60043-10-3 - eurobic9

J. Mattsson, B. Therrien
Eurobic9, 2-6 September, 2008, Wrocław, Poland
O4. Supramolecular Trojan Horse for Cancer Cells
Department of Chemistry, University of Neuchatel, Case postale 158, 2009, Neuchatel, Switzerland
e-mail: johan.mattsson@unine.ch
Combining the "molecular clip" strategy developed by Stang [1] and the "molecular paneling" strategy
developed by Fujita [2], we recently synthesized the "complex-in-a-complex" cations [(acac) 2 Pd⊂Ru 6 (p-
Pr i
C 6 H 4 Me) 6 (tpt) 2 (dhbq) 3 ] 6+
and [(acac) 2 Pt⊂Ru 6 (p-Pr i
-C 6 H 4 Me) 6 (tpt) 2 (dhbq) 3 ] 6+
[3]. The cytotoxicity of the two
host-guest systems, the empty hexaruthenium cage and the free complexes Pd(acac) 2 and Pt(acac) 2 have been
evaluated as anticancer agent against A2780 human ovarian cancer cells. The difference in cytotoxicity of the
different systems suggests that like a "Trojan Horse", once inside a cell, passive leaching of the guest from the
cage accelerates and increases the cytotoxic effect.
References:
[1]C. J. Kuehl, Y. K. Kryschenko, U. Radhakrishnan, S. Russell Seidel, S. D. Huang, P. J. Stang, Proc. Natl.
Acad. Sci. USA, 2002, 99, 4932-4936.
[2] M. Fujita, M. Tominaga, A. Hori, B. Therrien, Acc. Chem. Res., 2005, 38, 371-380.
[3] B. Therrien, G. Süss-Fink, P. Govindaswamy, A. K. Renfrew, P. J. Dyson, Angew. Chem. Int. Ed., 2008, 47,
3773-3776.
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