ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
P159. Copper(II) Complexes with Allantoin and Hydantoin. Synthesis,
Spectroscopic and Pharmacokinetic Characterization
M. Puszyńska-Tuszkanow, a M. Cieślak-Golonka, a G. Maciejewska, a T. Grabowski b
a Faculty of Chemistry, Wrocław University of Technology, Smoluchowskiego str. 23, 50-372 Wrocław, Poland
b Pharmacokinetic Testing Centre Filab-Ravimed, Polna str. 54, 05-119 Łajski k/Legionowa, Poland
Allantoin and hydantoin (Fig 1) are natural species playing a crucial role e.g. in the purine metabolisms [1].
Besides, allantoin is widely used in dermatology as a drug [2, 3]. In contrast to hydantoin, no data that cover the
topic of the coordination properties of allantoin was found in the literature.
In this work the interaction of allantoin and hydantoin with copper(II) ion in ammonia solution was investigated.
As a result, four new Cu(II) complexes were isolated and spectroscopically (UV/Vis, FIR, IR) characterized.
For a preliminary evaluation of the potential pharmacokinetic activity of the species, the calculation of
characteristic physiochemical parameters like e.g. the magnitude of polar surfaces of a molecule, lipophilicity
and hydrogen bonding were performed and discussed.
N(3)
O
O
HN3
2
1NH
4
5
NH
Fig 1 allantoin hydantoin
References:
[1]. An encyclopedia of chemicals, drugs, and biologicals (2001);
[2]. V. Shevstopolov, P. Guskov, et. al., Biology Bulletin, 33, (2006), 437-440;
[3]. P. Guskov, N. Procofev, et. al., Dokl. Biochem. Biophys., 389, (2004), 320-324;
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O
NH 2
N(1)
N(3)
O
HN
2
3
1NH
4
5
O
N(1)