ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
P79. Indenyl Iron Carbonyls as CO-releasing Molecules
L. Hewison a , B. Mann a , P. Sawle b , R. Motterlini b
a
Department of Chemistry, University of Sheffield, Brook Hill, S3 7HF, Sheffield, United Kingdom
e-mail: chp05lh@sheffield.ac.uk
b
Vascular Biology Unit, Department of Surgical Rese, Northwick Park Institute for Medical Research, HA1
3UJ, Harrow, Middlesex, United Kingom
Heme oxygenase is an important enzyme within our bodies, converting heme to carbon monoxide (CO), Fe II , and
initially biliverdin that is subsequently reduced to bilirubin.[1] Carbon monoxide plays a vital role in the
cardiovascular system and provides protection against reperfusion injury and inflammation. The use of metal
carbonyls to deliver CO in a solid form was first described in 2002, [2] and a range of viable metal carbonyls
have been described and recently reviewed.[3]
The use of [CpFe(CO)3] + and its derivatives as CO releasing molecules has recently been reported.[4] As
replacement of cyclopentadienyl by indenyl frequently increases rates, as has been reported for [CpFe(CO)3] +
and [(indenyl)Fe(CO)3] + , [5] a selection of derivatives of [(indenyl)Fe(CO)3] + have been examined as CO
releasing molecules. The rate of CO release to myoglobin and macrophages in culture was used to examine the
effect of the compounds on cell viability, toxicity and suppression of nitrite formation. While t1/2 is 69 min for
[CpFe(CO)3] + , it reduces to