ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
P183. New Rhodium Water-soluble Complexes with
1,3,5-triaza-7-phosphaadamantane
P. Smoleński a, b , M. Fátima C. Guedes da Silva a, c , F. P. Pruchnik b , A. J. L. Pombeiro a
a Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, TU Lisbon,
Av. Rovisco Pais, 1049–001 Lisbon, Portugal
b Faculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wrocław, Poland
c Universidade Lusófona de Humanidades e Tecnologias, ULHT Lisbon, Av. do Campo Grande, 376, 1749-024,
Lisbon, Portugal
Water-soluble phosphines are playing an important role in studies on chemical diagnostic and therapy. Indeed,
following their adaptable capacity to coordinate metals ions and their radioisotopes, they allow the preparation of
new water-soluble radiopharmaceutical compounds. The strong metal-phosphorus bond promotes the stability of
the complexes even under less favourable conditions as those encountered in vivo. In order to promote the
stability of Rh I systems in aqueous phase, we selected the chemically stable and water-soluble 1, 3, 5-triaza-7phosphaadamantane
(PTA) ligand. Its coordination chemistry has experienced in the last years a rapid
development mainly justified by the search for water soluble transition metal phosphine complexes which could
find several applications e.g. as catalysts in aqueous phase or water-soluble antitumor agents.
In this contribution we report the syntheses, structural and spectroscopic characterization of some new rhodium
complexes: [RhCl2(PTA-H)(PTA)] (1), [RhCl2(PTA)4]Cl (2), [Rh(CO)(PTA)4]Cl (3) and [RhH(PTA)4] (4). All
of them were characterized by IR, 1 H, 13 C and 31 P NMR spectroscopies, elemental analyses and (for 1 - 3) also
by X-ray structural analysis.
P
PTA = PTA-H =
N N
N H
N
N
+
N
Acknowledgements: This work has been partially supported by the Foundation for Science and Technology
(FCT), grants and BPD/20869/04, and its POCI 2010 programme (FEDER funded).
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