livro

Saúde INCT – Institutos Nacionais de Ciência e Tecnologia
INCT – Institutos Nacionais de Ciência e Tecnologia
Saúde
• Impact of short-term preconceptional exposure to particulate air pollution
on treatment outcome in couples undergoing in vitro fertilization and
embryo transfer (IVF/ET) - Paulo Marcelo Perin et al.
• Acute cardiovascular and inflammatory toxicity induced by inhalation of
diesel and biodiesel exhaust particles - Jôse Mára de Brito et al.
• The effects of chronic exposure to traffic derived air pollution on the
ocular surface. - Novaes P et al.
Contacts
Faculdade de Medicina da Universidade de São Paulo
Departamento de Patologia - Laboratório de Poluição
Atmosférica Experimental – LIM05
Av. Dr. Arnaldo, 455 1º Andar – sala 1220
São Paulo – SP – Brasil
01246-903
Tel: 0055 (11) 3061-7214; 0055 (11) 3061-8521
E-mail: info@inaira.org
Ergoespirometria
National Institute of Science and Technology of
Investigation in Immunology – iii-INCT
Guilherme Loureiro Werneck, J. Gustavo P. Amarante-Mendes, Jorge Kalil,
Luisa Karla de Paula Arruda, Luiz Carlos de Sá Rocha, Luiz Vicente Rizzo,
Luiza Guilherme Guglielmi, Manoel Barral Neto, Marcelo M Brigido, Maria
Regina Alves Cardoso, Mario Palma, Osmar Malaspina, Pedro Giavina
Bianchi, Pedro Michaluart Junior, Roque Pacheco de Almeida, Sandro José
de Souza, Verônica Coelho
Main research topics
It is well established today that several diseases of previously unknown
etiology are due to dysfunctions of the immune system, either
by excessive or inadequate inflammatory responses. The Institute for
Investigation in Immunology (iii) is precisely focused on this issue. Our
areas of interest (autoimmune diseases, immunodeficiencies and HIV/
AIDS, leishmaniasis, transplants, cancer and allergies) pertain to health
problems that affect millions of people in Brazil and all throughout
the world. Besides its socio-economic relevance, these diseases are
relevant biological models since their study allow the advancement of
knowledge of pathophysiologic mechanisms and, therefore, leading to the
design of therapeutic strategies based on disease pathogenesis.
Summary of achievements and perspectives
The core research areas at iii regard some of the most important topics in
medical immunology. In autoimmunity we will advance the development
of our candidate vaccine to prevent S. pyogenes infection and Rheumatic
Fever with the first phase I and II clinical trials. We will also study and try
novel immunomodulatory approaches to Crohn’s disease. Several studies
are planned -and some already underway- to study HIV pathogenesis and
the development of AIDS. We will also study adjuvant therapy and conduct
a phase I clinical trial of the first candidate AIDS vaccine developed
in Brazil, which is already patented, in addition to test other products
in primates. In primary Immunodeficiencies, we will extend the genetic
studies, improving their diagnosis and treatment of patients, and test a
new adjuvant therapy for hypogammaglobulinemia. We will conduct two
clinical studies on prevention and treatment of visceral leishmaniasis.
In the area of transplants, we will study the mechanisms involved in
graft rejection to detect new targets of intervention. We will also test an
immunobiological drug developed by us to treat acute graft rejection.
In the area of câncer and immunotherapy we will conduct clinical trials
with two new products. In the area of allergy, we will study potential new
allergens for diagnosis and treatment and develop recombinant allergens
to be used in those two areas.
HIV-infected pregnant women downregulate HIV-1 replication: effect
enhanced by antiretroviral treatment. AIDS (London).,v.23,p.9-18, 2009.
Agondi RC, Barros MT, Rizzo LV, Kalil J, Giavina-Bianchi P. Allergic
asthma in patients with common variable immunodeficiency. Allergy.
2009 Oct 15
Alvarez, M. S, LR; Pineda, MA, González, MP, Entringer, PF, Oliveira, C. I,
Nascimento, IP, Souza, AP, Corvo, L, Bonay,P , Brodskyn, C. I, BarralL,A,
BARRAL-NETTO,M. Searching Genes Encoding Leishmania Antigens for
Diagnosis. Scholarly Research Exchange pp. 173039, 2009.
Contacts
Laboratório de Imunologia - Instituto do Coração
Av. Dr. Enéas de Carvalho Aguiar, 44, bloco II, 9º andar
Cerqueira César – São Paulo (SP) CEP 05403-900
Website: www.iii.org.br E-mail: comunicacao@iii.org.br
Laboratório de Imunologia do Instituto do Coração (InCor)
National Institute of Science and Technology in
Medicine Assisted by Scientific Computing –
MACC
Giraldi, Jauvane C. de Oliveira, Selan Rodrigues dos Santos, Antonio
Tadeu Azevedo Gomes, Débora Christina Muchaluat Saade, Bruno
Schulze, Maria Cristina Silva Bôeres
Main research topics
Computational modeling and simulation of complex physiological systems
and its applications in the diagnosis, treatment and planning of medical
procedures.
Advanced processing of medical images, including visualization and
three-dimensional reconstruction of structures of medical relevance and
its applications in the image-based diagnosis, in the modeling and computacional
simulation of physiological systems and in surgical planning.
Collaborative virtual environments of virtual and augmented reality and
telemanipulation in medicine for training, human resources formation and
surgical planning.
Information systems in health, with applications to emergency medical
attendance and vigilance in public health.
High Performance Distributed Computing Cyberenvironments for Medical
Applications in the aforementioned areas.
Summary of achievements and perspectives
System AToMS for the Remote Support to Emergency Medical Attendance
applied to acute myocardial infarction.
System ImageLab for the processing of medical images and its applications
in the image-based diagnosis, reconstruction of geometrical structures
of medical relevance for computational modeling and simulation, in
vivo characterization of mechanical properties.
System HeMoLab for the Modeling and Computational Simulation of the
Human Cardiovascular System and its applications in the diagnosis,
treatment, surgical planning and formation of human resources.
Main publications
1) LEIVA, J.S. ; BLANCO, P.J. ; BUSCAGLIA, G.C. Iterative strong coupling of
dimensionally-heterogeneous models. International Journal for Numerical
Methods in Engineering, v. 81, p. 1558-1580, 2009.
2) BLANCO, P.J. ; URQUIZA, S.A. ; FEIJÓO, R.A. On the potentialities of
3D-1D coupled models in hemodynamics simulations. Journal of Biomechanics,
v. 42, p. 919-930, 2009.
3) AUSAS, R.F. ; SOUSA, F.S. ; BUSCAGLIA, G.C. An improved finite
element space for discontinuous pressures. Computer Methods in Applied
Mechanics and Engineering, v. 199, p. 1019-1031, 2010.
4) SEIXAS, F.L. ; CONCI, A. ; MUCHALUAT-SAADE, D. C. ; SOUZA, A.S.
Intelligent automated brain image segmentation. International Journal of
Innovative Computing and Applications, v. 2, no. 1, p. 23-33, 2009.
5) MALINOSKI, I. ; VICOSO, R. P. ; CORREA, B. S. P. M. ; GOMES, A. T. A.;
ZIVIANI, A. Suporte Remoto ao Atendimento Médico Emergencial via Dispositivos
Móveis. In: Workshop de Informática Médica (WIM), 2009, Bento
Gonçalves, RS - Brasil. Anais do IX Workshop de Informática Médica, 2009.
6) B.R., SCHULZE ; O., RANA ; J.N. SOUZA. Advanced Strategies in Grid Environments:
Models and Techniques for Scheduling and Programming. Concurrency
and Computation: Practice and Experience, v. 21, p. 1667-1671, 2009.
Management committee
Jorge Kalil (Coordinator)
Main publications
Manoel Barral-Neto (Vice-coordinator)
L. Guilherme, J Kalil. Rheumatic Fever and Rheumatic Heart Disease:
Mario Palma
Cellular Mechanisms Leading Autoimmune Reactivity and Disease. J Clin.
Management committee
Ana Maria Moro
Immunol., 2009
Raúl A. Feijóo (Coordinator)
Esper G. Kallas
Clarêncio, J, Oliveira, CI de, Favali, C,Medina, O, Caldas, A, Costa, J,
Artur Ziviani (Vice-coordinator)
Luiz Vicente Rizzo
Costa, D, Brodskyn, CI, Barral, A, Barral-Netto, M. Could the lower
Nelson Albuquerque de Souza e Silva
frequency of CD8+CD18+CD34RO+ lymphocytes be biomarkers of
Marco Antonio Gutierrez
Associated Institutions
human VL? . International Immunology, v.21, p.137-144, 2009.
Alexandra Maria Vieira Monteiro
USP; Instituto Butantan; Ludwig Institute for Cancer Research; UNESP; Victora GD, Socorro-Silva A, Volsi EC, Abdallah K, Lima FD, Smith RB,
Alair Augusto Sarmet Moreira Damas dos Santos
Fiocruz; UnB; UFMG; UFMG; PUC-RS; UFS
Moyses RA, Zárate-Bladés CR, Michaluart P, Silva CL, Kalil J, Coelho V.
Márcio Sarroglia Pinho
Immune response to vaccination with DNA-Hsp65 in a phase I clini-
Contacts
Main researchers
cal trial with head and neck cancer patients. Cancer Gene Ther. 2009
Associated Institutions
Av. Getúlio Vargas 333, Quitandinha
Aldina Maria Prado Barral, Aluisio Augusto C. Segurado, Amélia Maria Jul;16(7):598-608
UFPB; USP; UFRJ; UnB; UFU; UFF; UFSC; PUC-RS; UERJ; UFPR; UFC; CEP 25651-075, Petrópolis - Rio de Janeiro, Brasil.
Ribeiro de Jesus, Amilcar Tanuri, Ana Maria Caetano de Faria, Ana Maria Bento, Cleonice AM, Hygino, Joana, Andrade, Regis M, Saramago,
UFSCAR; UFRN
Telefone: + 55 24 2233 6099
Camargo, Ana Maria Moro, Andrea Maranhão, Anna Carla Goldberg, Carmen SM, Silva, Renato G, Silva, Agostinho AL, Linhares, Ulisses C,
Fax: + 55 24 2233 6071
Claudia Ida Brodskyn, David Saitovitch, Edecio Cunha-Neto, Ester Brindeiro, Rodrigo, Tanuri, Amilcar, Rosenzwajg, Michelle, Klatzmann,
Main researchers
E-mail: alinevaz@lncc.br
Sabino, Esper G. Kallas, Fábio F M Castro, Francisco Inácio P.M. Bastos,
David, Andrade, Arnaldo FB, Tanuri, Amílcar. IL-10-secreting T cells from
Pablo J. Blanco, Gustavo C. Buscaglia, Denise Guliato, Gilson Antonio http://macc.lncc.br
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