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Saúde INCT – Institutos Nacionais de Ciência e Tecnologia
INCT – Institutos Nacionais de Ciência e Tecnologia
Saúde
Marcelino, Juan J. Calvette, Kathleen Fernandes Grego, Kátia Cristina Bárbaro,
Lauro Barata, Marcelo A. B. V. Guimarães, Marcelo Giordan, Marcos
Boulos, Marcos Roberto De Mattos Fontes, Maria Elena Lima Garcia, Maria
Ermelinda do Espírito Santo Oliveira, Maria Fátima Barbosa Souza, Mariana
Margarita M. Quiroga, Marília Facó Soares, Marta Maria Antoniazzi, Martha
Marandino, Melissa Mascheretti, Miguel Trefaut Rodrigues, Myriam Elizabeth
Velloso Calleffo, Niede Guidon, Norma Yamanouye, Osvaldo Augusto
Sant’anna, Otavio A. V. Marques, Pasesa Quiroga Quispe, Paulo Abati,
Paulo Roberto Sposito De Oliveira, Paulo Sérgio Lacerda Beirão, Priscila
Faulhaber Barbosa, Regina Maria De Carvalho Erthal, Ricardo Jannini
Sawaya, Richard Hemmi Valente, Rute Maria Gonçalves de Andrade, Sávio
S. Sant’anna, Solange Maria Toledo Serrano, Suzana Cezar Gouveia Fernandes,
Valquiria Abrão Coronado Dorce, Luiz Vicente Rizzo, Wilmar Dias da
Silva, Wilson Fernandes, Yara Cury
Main research topics
Immunology; Physiopathology; Biochemistry and Molecular Biology; Biodiversity
and Evolution; Actions in Health [Dissemination, Education and
Production]; Actions in Amazonia; Translational Research [Innovation]
27-residue peptide. Toxicon 55: 481-7, 2010.
4. JARED C, ANTONIAZZI MM, JORDÃO AEC, SILVA JRMC, GREVEN H,
RODRIGUES MT. Parotoid macroglands in toad (Rhinella jimi): Their structure
and functioning in passive defence. Toxicon 54: 197-207, 2009.
5. MARANDINO M, OLIVEIRA AD, MORTENSEN M. Discussing biodiversity
in dioramas: a powerful tool to museum education. International Council
of Museums 29: 30-36, 2009.
6. MARENGO EB, COMMODARO AG, PERON JP, DE MORAES LV, PORTARO
FC, BELFORT R JR, RIZZO LV, SANT’ANNA OA. Administration of Mycobacterium
leprae rHsp65 Aggravates Experimental Autoimmune Uveitis in
Mice. PLoS ONE 4: e7912, 2009.
Contacts
Av. Vital Brazil, 1500 - 05503-900 - São Paulo - Brasil
Fone: 55-11-3726-7222 (ramal 2001)
E-mail: incttox@butantan.gov.br
Site: www.incttox.com.br
Antonio Waldo Zuardi, Regina Helena Costa Queiroz, Márcio Versiani,
Alexandra Ioppi Zugno, Maria Inês da Rosa, Carla Denise Bonan, Elke
Bromberg, Mauricio Reis Bogo, Mônica Ryff Moreira Roca Vianna, Rodrigo
Grassi de Oliveira
Main research topics
- Investigation of the clinical use of tianeptine as a treatment for bipolar
depression
- Development of the therapeutic use of Canabidiol in social anxiety
disorders
- Evaluation of the use of ayahuaska derivatives in an animal model of
anxiety
- Evaluation of the therapeutic use of neuropeptides receptors agonists
and antagonists, focusing on the Gastrin releasing peptide receptor
(GRPR), as antitumor drugs (colon cancer)
- Evaluation of the clinical use of BDNF as: a) activity biomarker; b)
staging biomarker; and c) therapeutic response biomarker in major
psychiatric disorders (schizophrenia and bipolar disorder).
- Evaluation of the clinical use of oxidative stress markers such as: a)
activity biomarker; b) staging biomarker and c) therapeutic response
biomarker in major psychiatric disorders (schizophrenia and bipolar
disorder).
- Evaluation of the therapeutic use of agents that affect epigenetic
mechanisms, promoting chromatin remodeling (for example, histone
deacetilase inhibitors) as potential antitumor drugs (colon cancer).
tration in rats that had been previously presented to stressor agents, as
this can be a new pharmacological tool in the treatment of depression.
Main publications
- Kapczinski F, Dal-Pizzol F, Teixeira AL, Magalhaes PV, Kauer-Sant’anna
M, Klamt F, de Bittencourt Pasquali MA, Quevedo J, Gama CS, Post R.A
systemic toxicity index developed to assess peripheral changes in mood
episodes. Molecular Psychiatry 2010 [Epub ahead of print].
- Fortunato JJ Réus GZ, Kirsch TR, Stringari RB, Fries GR, Kapczinski F,
Hallak JE, Zuardi AW, Crippa JA, Quevedo J. Effects of beta-carboline
harmine on behavioral and physiological parameters observed in the
chronic mild stress model: Further evidence of antidepressant properties.
Brain Res Bull. 2010 16;81(4-5):491-6.
- Abujamra AL, Dos Santos MP, Roesler R, Schwartsmann G, Brunetto AL.
Histone deacetylase inhibitors: A new perspective for the treatment of
leukemia. Leuk Res. Leuk Res. 2010 34(6):687-95
Contacts
Página: http://www.ufrgs.br/inct_tm/
Flavio Kapczinski: kapcz@terra.com.br
José Alexandre Crippa: jcrippa@fmrp.usp.br
Jaime Hallak: jhallak@fmrp.usp.br
Summary of achievements and perspectives
The Subprograms BIOCHEMISTRY AND MOLECULAR BIOLOGY, PHYSIO-
PATHOLOGY and IMMUNOLOGY have started isolating and characterizing
animal venoms and toxins, and studying the structural immunochemical
aspects, inflammatory/anti-inflammatory actions and local and systemic
effects of biologically active molecules present in these venoms, especially
of snakes of the genera Bothrops, Micrurus and Crotalus and of different
Summary of achievements and perspectives
species of arachnids. The results obtained were presented at national
Biomarkers – Several papers have been published concerning oxidative
and international congresses, besides being published in specialized
stress, neurotrophins and cytokines as mediators of cognitive impairment
journals with good reach of the international scientific community. In the
and health, which normally occur in recurrent mood episodes in bipolar
Subprogram Immunology, two themes were included EFFECT OF SBA-15
patients. We have also shown, in a preliminary way, that BDNF serum
NANOSTRUCTURED SILICA IN THE DEVELOPMENT OF THE IMMUNE
RESPONSE, and EVALUATION OF THE PARTICIPATION OF HSP60/65 IN
Snake capture
levels are considerably reduced in medicated and non-medicated bipolar
patients compared to controls, with no significant difference on its levels
CHRONIC-DEGENERATIVE PROCESSES. With regard to Patents, in 2009,
between medicated and non-medicated patients. Furthermore, we have
one filed was: PEPTIDES, COMPOSITIONS, AND USES THEREOF Pub. No.
developed a systemic toxicity index to evaluate peripheral changes in
WO/2009/093189. This invention shows peptides capable of stimulating
mood episodes. So far, we have around 150 patients involved in clinical
the production of extracellular matrix (ECM) proteins of fibroblasts, for
research, where we will be able to evaluate serum BDNF changes as
example, which can therefore be utilized as agents for tissue regeneration
predictors to treatment response in bipolar depression, as well as their
and as cosmetics. Another patent was the IMMUNOSSUPRESSOR EFFECT
OF NON IMMUNOGENIC PROTEIN OF THE VENOM OF Lachesis muta that
is in preparation in partnership with the company CRISTALIA LABORATORY.
National Institute of Science and Technology in
Translacional Medicine – INCT-TM
relationship with cognitive function.
Animal model of mania induced by ouabain – Intracerebroventricular
(ICV) administration of ouabain in rats has been suggested for mimicking
Laboratory of panic and breathing
The institutional website www.incttox.com.br, as well as the virtual envi-
some of the bipolar mania symptoms presented in humans. We have
ronment of learning, SCIENCE NETWORK www.cienciaemrede.com.br, was Management committee
evaluated behavioral and biochemical effects induced by the ICV admi-
launched, constituting tools of internal communication and instruments of Flávio Kapczinski (Coordinator)
nistration of ouabain in rats, immediately and 7 days after one single ICV
mediation between non-specialists and the scientific community.
Main publications
José Alexandre Crippa (Vice-coordinator)
Jaime Hallak
Antonio Egídio Nardi
administration, on the locomotor activity (with the open-field test) and
on oxidative stress parameters. The results suggest that ouabain induce
manic symptoms and can be used as an animal model of mania to test
National Institute of Science and Technology of
Translational Neuroscience – INNT
1. ALVARENGA L, MOREAU V, FELICORI L, NGUYEN C, DUARTE C,
João Quevedo
the hypothesis of an involvement of oxidative stress in Bipolar Disorder.
CHAVEZ-OLORTEGUI C, MOLINA F, MARTIN-EAUCLAIRE MF, GRANIER Emílio Streck
Effects of cannabidiol on amphetamine-induced oxidative stress generation Management committee
C. Design of antibody-reactive peptides from discontinuous parts of Nadja Schröder
in an animal model of mania – Cannabidiol (CBD) is found in Cannabis Esper Abrão Cavalheiro (Coordinator)
scorpion toxins. Vaccine 28: 970-80, 2010.
Rafael Roesler
sativa and can present similar pharmacological profiles to mood stabilizers, Vilma Regina Martins (Vice-coordinator)
2. BATISTA IF, RAMOS OH, VENTURA JS, JUNQUEIRA-DE-AZEVEDO IL, HO
including antioxidant and neuroprotective properties. We have studied the Fernando Garcia de Mello
PL, CHUDZINSKI-TAVASSI AM. A new Factor Xa inhibitor from Amblyomma Associated Institutions
effects of CBD in a D-amphetamine (D-AMPH)-induced animal model of Ivan Izquierdo
cajennense with a unique domain composition. Arch Biochem Biophys UFRJ; UNESC; PUCRS; UFRGS
mania. Our results suggest that CBD has no effects on D-AMPH-induced Roberto Lent
493: 151-156, 2010.
hyperlocomor activity, but presents protective effects on protein oxidative Sérgio T. Ferreira
3. DIAS-LOPES C, GUIMARÃES G, FELICORI L, FERNANDES P, EMERY L, Main researchers
damage, and increase BDNF levels in the reversal model.
Vivaldo Moura Neto
KALAPOTHAKIS E, NGUYEN C, MOLINA F, GRANIER C, CHÁVEZ-OLÓR- Clarissa Severino Gama, Keila Maria Mendes Ceresér, Márcia Kauer-
Therapeutic evidences of the use of ayahuasca and its derivatives (har-
TEGUI C. A protective immune response against lethal, dermonecrotic -Sant’Anna, Lunardi Brunetto, Ana Lucia Abujamra, Fábio Klamt, Gilberto
mine and harmaline) in psychiatric disorders, especially depression – We Associated Institutions
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and hemorrhagic effects of Loxosceles intermedia venom elicited by a Schwartsmann, Ricardo Machado Xavier, Ana Chrystina de Souza Crippa,
evaluated the behavioral and physiological effects of harmine adminis- PUC-RS; UFRJ; ILPC/SP; Unifesp; Rede de Hospitais Labs-D’Or/RJ; Hos-
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