livro

Saúde INCT – Institutos Nacionais de Ciência e Tecnologia
INCT – Institutos Nacionais de Ciência e Tecnologia
Saúde
pital Municipal Souza Aguiar/RJ; Hospital Adventista do Silvestre/RJ
Main research topics
Development and plasticity of the nervous system
Neuropharmacology and neurophysiology of memory
Neurodegenerative diseases (Alzheimer’s, Parkinson’s, Prion and retinal
degeneration)
Plasticity of neural progenitor cells and their therapeutic use
Research and treatment of epilepsy
The physiology of glia cells and glia cell-derived tumors
Summary of achievements and perspectives
The results of this first year at the INNT can be divided into two main
groups: (a) those aimed at understanding the normal morphophysiology
of the nervous system and (b) those who seek to understand the pathophysiological
processes underlying the main neurological disorders.
In the first group, we highlight the study of development and plasticity of
the normal nervous system and on the role of different cell populations
in these processes (Fig.1). This study allowed the observation that the
development of the mammalian brain, based on the number of neurons
and glia cells, follows a linear increase pattern - from those species with
lower brain development to primates and humans.
In this first group of results are also the studies on memory with seminal
contributions to the understanding of the mechanisms related to the
consolidation and those critical for recovering or forgetting the stored
information.
In the second group, we highlight that allow the understanding of the
mechanisms related to function loss and/or neuronal death in important
neurological disorders, some of them characterized by progressive neurodegeneration
(Pakinson´s, Alzheimer´s disease, epilepsy). In parallel,
other studies search for strategies aimed at avoiding the neuronal
function loss by potential neuroprotective agents
Another important strategy developed by INNT investigators is related
to the development of specific tools which will permit to understand the
mechanisms associated with the growth of glia cell-derived tumors and
how they invade the normal brain tissue. Glia cell-derived tumors are the
most frequent human brain tumor and one of them, glioblastoma, is very
aggressive leading to death approximately 6 months after diagnosis. The
team isolated glioblastoma cells from human tumors that when injected
into laboratory animals reproduce the phenotype of tumor, particularly,
the invasion of brain tissue (Fig. 4). These studies will also allow the
search for better drugs to control the tumor growth and the subsequent
invasion of the normal surrounding tissue.
In this group are also the studies that have enabled to understand the
mechanisms related to epileptogenesis and anti-epileptogenesis by using
pioneering experimental model developed by the group and its application
in unconventional laboratory animals allowing recognizing which brain
structures contribute in one or to another direction.
primate brain. J Comp Neurol, 513, 532-541.
Bandeira F, Lent R, Herculano-Houzel S (2009) Changing numbers of
neuronal and non-neuronal cells underlie postnatal brain growth in the
rat. Proc Natl Acad Sci U S A, 106, 14108-14113.
Clarke JR, Cammarota M, Gruart A, Izquierdo I, Delgado-García JM
(2010) Plastic modifications induced by object recognition memory
processing. Proc Natl Acad Sci U S A, 107, 2652-7.
da Silva RT, Hokoc JN, de Mello FG, Gardino PF (2009) Differential
immunodetection of L-DOPA decarboxylase and tyrosine hydroxylase in
the vertebrate retina. Int J Dev Neurosci, 27, 469-476.
Rossato JI, Bevilaqua LRM, Izquierdo I, Medina JH, Cammarota M -
Dopamine Controls Persistence of Long-Term Memory Storage. Science
325:1017-1020, 2009.
Contacts
Universidade Federal de São Paulo
Rua Botucatu, 862 - 04023-900 São Paulo, SP
Tel.: (11) 55492064; Fax: (11) 55739304
e-mails: esper@pq.cnpq.br;esper.nexp@epm.br
Heath neurons with normal arborization (A) and with an expressive
loss-of-connections when exposed to oligomers which are similar to
those produced in brains of Alzheimer’s pacients (B). The treatment
with insulin decreases the loss of neuronal connections caused by
oligomers (C)
National Institute of Science and Technology for
Translational Research on Health and Environment
in the Amazon Region – INPeTAm
Freitas Ferreira , Andrea Fiorani, Ari Miguel Teixeira Ott, Arneide Cemin Bandeira,
Bartira Rossi-Bergman, Bruno L. Diaz, Camila Sant’Anna Pimenta,
Carlos Everaldo Alvares Coimbra Junior, Cerli Rocha Gattass, Christianne
Bandeira de Melo, Claudia Equi, Denise Pires de Carvalho, Deusilene Souza
Vieira, Diego Escobar, Eduardo José Lopes Torres, Elaine Maria de Santana,
Eleonora Kurtenbach, Ene Glória da Silveira, Eulália Gonçalves de Aquino,
Felipe Sarcinelli Luz, Gunther Brucha, Gustavo Henrique Grimmer, Heloisa
Pacheco-Ferreira, Janine Simas Cardoso, Janne Cavalcante Monteiro, Jean
Remy Davé Guimarães, Jenifer Saffi, Jéssica Costa de Andrade, João Paulo
Torres, José Vicente Elias Bernardi, Juan Miguel Villalobo Salcedo, Juliana
P. Zuliani, Julieta Schachter, Katiane Guedes Brandão, Leonardo Calderon,
Leopoldo de Méis, Lucia Rejane Gomes da Silva, Lucinda Maria Dutra de
Souza Moreira, Mara Arruda, Marcos Andre Vannier dos Santos, Mariano
Gustavo Zalis, Marinês Rodrigues dos Santos Cezar, Mário Vaisman, Marlon
Fonseca, Marques Corrêa Franco, Mauro F Rebelo, Milton Nascimento,
Natascha Krepski, Rejane Corrêa Marques, Ricardo Agum Ribeiro, Ricardo
Ventura Santos, Rodrigo Guerino Stábeli, Rosane Silva, Sandra Feliciano de
Oliveira e Azevedo, Sandra Hacon, Sérgio Augusto Coelho de Souza, Tamar
Gomes Pinheiro Frankenfeld, Turan P. Urmenyi, Ulisses Gazos Lopes, Valdir
Alves Facundo, Wallace Pacienza Lima, Wanderley Rodrigues Bastos
Main research topics
- Identification of the sources of environmental pollutants in the Madeira/
Jamari basin.
- Evaluation of uptake and persistence of toxic substances in water
organisms; evaluation of interactions with man.
- Development of new biomarkers of human exposure to toxic substances
(breast feeding, blood, hair, enzymatic activities).
- Evaluation of nutritional and neurophysiological parameters; global
evaluation of health conditions of local riverside populations.
- Studies on the incidence of infectious and parasitic diseases.
- Identification of cellular and molecular mechanisms of human diseases
with regional impact.
Summary of achievements and perspectives
- Identification of sources of contamination in Rio Madeira basin; definition
of risk groups;
- Ecotoxicologic and limnologic studies, sampling of the soil for analysis
of chemical and biological pollutants;
- Characterization of human exposure through analysis of mercury
content in the hair;
- Evaluation of regional problems caused by growth of toxic cianobacteria
in water collections;
- Bacteriologic analysis of drinking water and its impact on the quality of
water;
- Evaluation of infectious and parasitic diseases, neurologic and metabolic
disturbances in local populations;
- Nutritional and neurophysiological evaluation of local populations;
- Identification of the epidemiology of malaria, leishmaniosis, and hepatitis
in the region;
- Mechanisms underlying the observed diseases were investigated at the
molecular and cellular level in experimental models in the laboratory;
- Educational ectivities are being conducted in order to attain social
awareness regarding the environmental causes of health problems;
- The first symposium on translational research on health and environment
was held at Porto Velho, Rondonia.
Coutinho-Silva R, Rossi-Bergmann B. Modulation of P2X(7) purinergic
receptor in macrophages by Leishmania amazonensis and its role in
parasite elimination. Microbes Infect. 11: 842-849, 2009.
2. Araujo RL, Andrade BM, Da Silva ML, Ferreira AC, Carvalho DP.
Tissue-specific deiodinase regulation during food restriction and low
replacement dose of leptin in rats. Am J Physiol Endocrinol Metab. 296:
E1157-E1163, 2009.
3. Marques RC, Dórea JG, Bernardi JV, Bastos WR, Malm O. Prenatal and
postnatal mercury exposure, breastfeeding and neurodevelopment during
the first 5 years. Cogn. Behav. Neurol. 22: 134-141, 2009.
4. Almeida MD, Marins RV, Paraquetti HH, Bastos WR, Lacerda LD. Mercury
degassing from forested and open field soils in Rondônia, Western
Amazon, Brazil. Chemosphere 77: 60-66, 2009.
5. Hayashi EA, Granato A, Paiva LS, Bertho AL, Bellio M, Nobrega A.
TLR4 promotes B cell maturation: independence and cooperation with B
lymphocyte-activating factor. J. Immunol. 184: 4662-4672, 2010.
6. Montalvão F, Almeida GM, Silva EM, Borges VM, Vasconcellos R, Takiya
CM, Lopes MF, Nunes MP, DosReis GA. Apoptotic lymphocytes treated
with IgG from Trypanosoma cruzi infection increase TNF-alpha secretion
and reduce parasite replication in macrophages. Eur. J. Immunol. 40:
417-425, 2010.
Contacts
Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde,
Bloco G, Ilha do Fundão, Rio de Janeiro, RJ, 21944-970
Correio eletrônico: inpetam@biof.ufrj.br
Página eletrônica: http://www.biof.ufrj.br/content/inct-inpetam
Teaching elements of science to the children of Puruzinho lake
Main publications
Arantes C, Nomizo R, Lopes MH, Hajj GN, Lima FR, Martins VR (2009)
Management committee
George Alexandre DosReis (Coordinator)
Olaf Malm (Vice-coordinator)
Volney de Magalhães Câmara
Luiz Hildebrando Pereira da Silva
Edson Rondinelli
Pedro Muanis Persechini
National Institute of Science and Technology for
Prion protein and its ligand stress inducible protein 1 regulate astrocyte
development. Glia, 57, 1439-49.
Associated Institutions
Tropical Diseases – INCT-DT
Arida RM, Scorza FA, Scorza CA, Cavalheiro EA (2009) Is physical activity UFRJ; UFR; UFPA; IPEPATRO; UFCSPA; CPqGM/FIOCRUZ; EXTRACTA
beneficial for recovery in temporal lobe epilepsy? Evidences from animal MOLÉCULAS NATURAIS S.A.
Management committee
studies. Neurosci Biobehav Rev, 33, 422-431.
Edgar M. Carvalho (Coordinator)
Azevedo FA, Carvalho LR, Grinberg LT, Farfel JM, Ferretti RE, Leite RE, Main researchers
Selma Jerônimo (Vice-coordinator)
Jacob FW, Lent R, Herculano-Houzel S (2009) Equal numbers of neuronal Alberto Arruda, Aline Roberta Polli, Alberto F. Nóbrega , Alvaro Augusto da
Main publications
Walderez Dutra
and nonneuronal cells make the human brain an isometrically scaled-up Costa Leitão, Ana Acácia Caruso-Neves, Ana de Escobar, Andrea Claudia
1. Chaves SP, Torres-Santos EC, Marques C, Figliuolo VR, Persechini PM, Songeli Freire Menezes
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