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Exact and Natural Sciences INCT – Institutos Nacionais de Ciência e Tecnologia Exatas e Naturais National Institute of Science and Technology in Astrophysics – INCTA Management committee João Evangelista Steiner (coordinator) Beatriz Leonor da Silveira Barbuy (vice-coordinator) Albert Bruch Daniela Lazzaro Hugo Vicente Capelato Thaisa Storchi Bergmann Associated Institutions IAG/USP, IF/USP, LNA/MCT, ON/MCT, INPE/MCT, UFRGS, OV/UFRJ, IF/ UFRJ, UFMG, UNIFEI, UNIPAMPA, UDESC, UESC, UCS, UNIFESP, UFABC, UNICSUL, UNIVAP. Main researchers João Evangelista Steiner. Beatriz Leonor da Silveira Barbuy, Albert Bruch, Daniela Lazzaro, Hugo Vicente Capelato, Thaisa Storchi Bergmann, Luís Raul Weber Abramo, François Christophe Cuisinier, Adriano Hoth Cerqueira, Roberto Cid Fernandes Junior, Jacques Raymond Daniel Lépine, Laerte Sodré Junior, Kepler de S. Oliveira Filho, Ioav Waga, Luiz Paulo Ribeiro Vaz Summary of achievements and perspectives In May 2009 the Scientific Committee of INCTA decided to adopt as a method of planning, the elaboration of “White Papers” for the different activities. This is the first step of planning INCTA and a total of 22 White Papers were produced and can be found in the site: www.astro.iag.usp.br /~incta Brazil’s participation in the Gemini and SOAR observatories has already shown significant return. In Gemini, the Brazilian participation in refereed publications is already about 10%, using only 2.3% of the time. Altogether 69 Brazilian authors have signed papers with data from Gemini to date. In SOAR, scientific production is still incipient. This telescope began its operation five years after the Gemini. Still, we can say that Brazil accounts for 54% of the papers published to date, having used only 30% of the time. Perhaps more important at this time is that the SOAR Telescope has enabled Brazilian Astronomy to establish a world class instrumentation program. Two instruments have been built and a third is under construction. In terms of human resource training, the INCTA allocated the first postgraduate scholarships for Masters, restricted to emerging groups. The INCT-A acquires a computer with GPU technology, with high performance for acces to the whole community. Computational equipment for the emergent groups were also acquires. Through INCTA, Brazil became a member of the IVOA (International Virtual Observatory Alliance). Brazilian researchers have participated in international events in the IVOA. INCTA also formed a group on Education, with the goal of designing a course in astronomy for science teachers of primary and secondary schools throughout Brazil. Several study visits were made in order to understand the demand and propose partnerships. Contacts Rua do Matão, 1226 – Cidade Universitária – IAG/USP CEP:05508-090 – São Paulo/SP Tel: (11) 3091-2705 – Fax (11) 3091-2860 Email: incta-secret@astro.iag.usp.br ; steiner@astro.iag.usp.br Site: www.astro.iag.usp.br/~incta Gemini North - Mauna Kea, Hawaii National Institute of Science and Technology of Bioanalytics – INCTBio Management committee Prof. Lauro Tatsuo Kubota (Coordinator) Profa. Marília de Oliveira Fonseca Goulart Profa. Marina Franco Maggi Tavares Prof. Reinaldo Calixto de Campos Prof. Yoshitaka Gushikem (Vice-coordinator) Associated Institutions DQ/CFM-UFSC; FCFRP-USP; IQB-UFAL; IQSC-USP; IQ-Unicamp; IQ-USP; PUC-RJ; UEL; UFABC; UFG; UFMA; UFMG; UFRJ; UFSCar; UFSM; UFVJM; UnB; UNESP; Unifal; UNISC Main researchers Alviclér Magalhães, Ana V.C. Simionato, Auro A. Tanaka, Carla B.G. Bottoli, César R.T. Tarley, Claudimir L. do Lago, Dosil P. Jesus, Eduardo C. da Rocha, Emanuel Carrilho, Érico M.M. Flores, Fabio Augusto, Fábio C. Gozzo, Flávio S. Damos, Jez W.B. Braga, José A. F. da Silva, Lauro T. Kubota, Marcelo M. Sena, Marcello G. Trevisan, Marco A.Z. Arruda, Marco F. Ferrão, Marília O.F. Goulart, Marina F.M. Tavares, Orlando Fatibello Filho, Pablo A. Fiorito, Pedro M. Padilha, Reinaldo C. Campos, Ricardo E. Santelli, Ronei J. Poppi, Rose Mary Z.G. Naal, Susana I.C. Torresi, Wendel A. Alves, Wendell K.T. Coltro, Yoshitaka Gushikem, Zeki Naal. Main research topics - Development of separation techniques with the aim to study secondary plant metabolics, biomarkers of some disease and enzymes related toneuropsychiatric disorders. 179
Exatas e Naturais INCT – Institutos Nacionais de Ciência e Tecnologia INCT – Institutos Nacionais de Ciência e Tecnologia Exatas e Naturais - Employment of second-order chemometric method to the direct determination of drug in the biological matrices and analysis of drugs by image spectroscopy. - Generation of integrate systems that combine the unique properties of the nanostructures with the molecular recognition capacity for the development of sensors and biosensors. - Development of the analytical methods to be applied in the metallomic and proteomic studies in living organisms (humans, animals and vegetables). - Integration of different analytical techniques with separation procedures allowing to elucidate functional and physiological aspects of the metaloproteins in living organisms. Summary of achievements and perspectives The researches of INCTBio focused on the investigation of biomarkers, establishment of the enzymatic assays for the neuropsychiatric disorders, genetic classifications of bacteria related to the acidity of juices from acid fruits, studies of secundary metabollic of plants and investigations of individual peptides maps. These efforts were always to search to combine separation techniques with mass spectrometry. Other point explored was the use of spectroscopy techniques like 1H RMN spectroscopy and chemometric analysis in the differentiation of healthy and non-healthy pacients. Great efforts were also done with the aim to develop nanostructured materials possibles to be used in the biomolecules recognitions for the sensors and biosensors development. The purpose of this research is the development of analytical devices, which can be used in simple and fast diagnosis processes for diseases or intoxications, with the concept of point-of-care. Main publications - R.F. Carvalhal, M.S. Kfouri, M.H.O. Piazetta, A.L. Gobbi, L.T. Kubota, Anal. Chem., 82, 1162-1165, (2010). - J. Arguello, H.A. Magosso, R.R. Ramos, T.C. Canevari, R.Landers, V.L. Pimentel, Y. Gushikem, Electrochim. Acta, 54, 1948, (2009). - F. D. A. Dos Santos Silva, C. B. Lopes, P. R. Lima, E. de O. Costa, L. T. Kubota, M. O. F. Goulart, Electrochem. Commun., 450, (2010). - F. Augusto, E. Carasek, R.G.C. Silva, S.R. Rivellino, A.D. Batista, E. Martendal, J. Chromatogr. A, 1217, 2533 (2010). - G. R. M. Duarte, C. W. Price, J. L. Littlewood, D. M. Haverstick, J. P. Ferrance, E. Carrilho, J. P. Landers, Analyst, 135, 531, (2010). - A.V. C. Simionato, E. Carrilho, M. F. M. Tavares, Electrophoresis, 31, 1214, (2010). -A. H. Iglesias, L. F. A. Santos, F. C. Gozzo. Anal. Chem. 82, 909, (2010). -A. Sussulini, A. Prado, D.A. Maretto, R.J. Poppi, L. Tasic., C.E.M Banzato, M.A.Z. Arruda. Anal. Chem. 81, 9755, (2009). - R. C. F. Neves, P. M. Moraes, M. A. D. Saleh, V. R. Loureiro, F. A. Silva, M. M. Barros, C. C. F. Padilha, S. M. Alvesjorge, P.M. Padilha, Food Chem., 113, 679, (2009). -F.A. Duarte, C.A. Bizzi, F.G. Antes, V.L. Dressler, E.M.M. Flores, Spectrochim. Acta B. 64, 513, (2009). Scheme for the metalloproteomic studies employing 2D PAGE and LA-ICP-MS National Institute of Science and Technology on Complex Fluids – INCT-FCx Management committee Antônio Martins Figueiredo Neto (Coordinator) Luiz Juliano Neto (Vice-coordinator) Francisco Antonio Helfenstein Fonseca Iolanda Cuccovia Lia Queiroz do Amaral Luiz Roberto Evangelista Niels Olsen Saraiva Camara Sylvio Canuto investigate physical properties of liquid crystals, magnetic colloids, also known as ferrofluids, and fluids of biological interest. In connection with biological fluids, we focus the investigations on the properties of lipids and proteins, including their interactions, structure, and functions. One of the main lines of research of the Institute refers to the atherogenic characteristics of human lipoproteins, which are responsible for the transport of cholesterol in the organism. Summary of achievements and perspectives a) We have used physical and immunological methods to demonstrate the association between chronic periodontitis and indicators of risk of cardiovascular diseases. We have identified some of the non-linear optical characteristics of native and oxidized forms of the low-density lipoprotein (LDL), and established a protocol to quantify the atherogenic LDL by a physical method; (b) We have determined the characteristics of the emission spectrum of Europium-Tetracycline complexes in the presence of native atherogenic LDL. Using the results of this investigation, we have been able to propose new protocols for the quantitative analysis of LDL in the blood; (c) We have observed that a certain amount of statin taken by patients with a large risk of coronary disease has acted to decrease the concentration of LDL with atherogenic characteristics in the blood; (d) We have carried out in vitro studies of the internalization of iron oxide nanoparticles in mesenchymal stem cells to be used in therapeutic processes. We have been able to synthesize biocompatible ferrofluids on the basis of nanoparticles of iron oxides with several types of coatings; (e) We have investigated some elements of the innate and adaptative immune response of models in acute renal lesions in experimental animals and in transplanted patients. The results so far indicate that receptors of the innate immunity are directly involved in the acute renal lesion and have some influence in the expression of the cytoprotector molecules; (f) We have use defocus microscopy to measure fluctuations in red blood cells, macrophages, cardiomicytes, and stem cells of birds, with access to some mechanical properties of these cells; (g) We have investigated new characteristics of liquid crystals, micelle systems and lipid membranes. As a perspective of future interdisciplinary work, we plan to further investigate the atherogenic characteristics of LDL, as well as the synthesis and some applications of magnetic colloids. Laboratory of the Group of Complex Fluids of the Institute of Physics at USP. Experimental setup for Z-scan in a femtosecond time-scale National Institute of Science and Technology of Complex Systems – INCT-SC Main researchers Alexandre Souto Martinez, Allbens Atman Picardi Faria, André Maurício Conceição de Souza, Célia Anteneodo, Constantino Tsallis (Coordinator), Daniel Adrian Stariolo, Daniel Oliveira Cajueiro, Ervin Kaminski Lenzi, Evaldo Mendonça Fleury Curado (Vice-Coordinator, Fernando Dantas Nobre, Hans Jürgen Herrmann, Itzhak Roditi, Jeferson Jacob Arenzon, Jorge Simões de Sá Martins, José Ricardo de Sousa, José Roberto Castilho Piqueira, José Soares de Andrade Júnior, Jürgen Fritz Stilck, Liacir dos Santos Lucena, Luciano da Fontoura Costa, Luciano Rodrigues da Silva, Marcelo Lobato Martins, Marco Aurélio Rego Monteiro, Paulo Murilo Castro de Oliveira, Raul José Donangelo, Renio dos Santos Mendes, Ricardo Magnus Osório Galvão, Rita Maria Cunha de Almeida, Roberto Fernandes Silva Andrade, Ronald Dickman, Rosane Riera Freire, Suzana Maria Moss de Oliveira, Thadeu Josino Pereira Penna, Welles Antonio Martinez Morgado Main researchers Adriana Tufaile, Alberto Tufaile, Amando Siuiti Ito, Antônio José Palangana, Claudete Valduga, Claudio Benedito Silva Furtado, Cristiano Luis Pinto de Oliveira, Elisabeth Andreoli de Oliveira, Elisete da Conceição Quintaneiro Aubin, Everaldo Arashiro, Fernando Moraes, Giancarlo Espósito de Souza Brito, Hatsumi Mukai, Herch Moysés Nussenzveig, Italo Nunes de Oliveira, José Américo de Miranda Neto, Juliana Pereira, Kaline Coutinho, Karin do Amaral Riske, Lilia Coronato Courrol, Lionel Fernel Gamarra Contreras, Manuel Simões Filho, Marcelo Leite Lyra, Marcia Barbosa, Maria Aparecida Juliano, Maria Aparecida Neves Jardini, Maria Cristina de Oliveira Izar, Mário José de Oliveira, Nathan Bessa Viana, Oscar Nassif de Mesquita, Paulo Américo Maia Neto, Paulo Ricardo Garcia Fernandes, Rita Ruiz, Sarah Alves, Sergio Leonardo Gomez, Sérgio Paulo Bydlowski, Silvio Roberto de Azevedo Salinas, Suhaila Maluf Shibli, Sylvia Mendes Carneiro, Tânia Tomé, Ubirajara Agero Batista, Viviana Giampaoli, Wagner Figueiredo, Yan Levin Main publications 1) Monteiro AM, et al. Cardiovascular Disease Parameters in Periodontitis. J. Periodontology, 80, 378 (2009); 2) Gamarra L.F., et al. Characterization of the biocompatible magnetic colloid on the basis of Fe3O4 nanoparticles coated with dextran, used as contrast agent in MRI. J. Nanoscience and Nanotechnology 10, 4145 (2010); 3) Semedo P, et al. Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model. Stem Cells. 27, 3063 (2009); 4) Lepique, et al. HPV16 Tumor Associated Macrophages Suppress Antitumor T Cell Responses. Clin. Cancer Res. 15, 4391 (2009); 5) Lenzi, E. K et al. Non-Markovian diffusion and the adsorption-desorp- Associated Institutions CBPF; CEFET-MG; PUC-RJ; UEM; UFAM; UFBA; UFC; UFF; UFMG; UFRGS; UFRJ; UFRN; UFS; UFV; UnB; USP/Ribeirão Preto; USP/São Paulo–Politécnica; USP/São Carlos Main research topics 1) Complexity in biological systems; 2) Complexity in economical systems; Contacts Universidade Estadual de Campinas (Unicamp) Instituto de Química, Departamento de Química Analítica Cidade Universitária Zeferino Vaz s/n CEP: 13083-970 Caixa Postal: 6154 Campinas, SP Telefone: 55 19 3521-3127 e-mail: inctbio@iqm.unicamp.br; kubota@iqm.unicamp.br Homepage: www.inctbio.iqm.unicamp.br Main research topics The main goal of the National Institute of Science and Technology on Complex Fluids (INCT-FCx) is the organization of professionals in the areas of physics (including biophysics), chemistry (including biochemistry), biology, immunology, medicine, dentistry, and mathematics, in terms of a set of problems requiring an interdisciplinary approach. The INCT-FCx develops activities of research, teaching, and extension. We use experimental techniques and the analysis of theoretical models to tion process, Phys. Rev. E 81, 011116 (2010); 6) Levin, Y. et al. Ions at the Air-Water Interface: An End to a Hundred-Year-Old Mystery?, Phys. Rev. Lett. 103, 257802 (2009). Contacts Antônio Martins Figueiredo Neto Tel: (11) 3091-6830 E-mail: afigueiredo@if.usp.br Site: http://fluidos.usp.br/index.php 3) Nonextensive statistical mechanics - theory and applications; 4) Signal and image processing aiming analysis, detection and prediction. Summary of achievements and perspectives The INCT-SC presents a high scientific productivity, having published articles in scientific journals of high reputation. Until June 2010 our researchers have published 197 articles. Also a book was published, as well as several articles in conference proceedings. .The excellence and creativity was fostered in undergraduate, masters 180 181
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Ministério da Ciência e Tecnologi
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Introduction The National Institute
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Contents Introduction 5 Agricultura
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Agrárias INCT - Institutos Naciona
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24 Agrárias Henrique G. Zarbin, An
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Energia INCT - Institutos Nacionais
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Energia INCT - Institutos Nacionais
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36 Energia desenvolvimento de técn
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Engenharia e Tecnologia da Informa
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Exatas e Naturais INCT - Institutos
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Humanas e Sociais INCT - Institutos
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Ecologia e Meio Ambiente INCT - Ins
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