livro

Saúde INCT – Institutos Nacionais de Ciência e Tecnologia
INCT – Institutos Nacionais de Ciência e Tecnologia
Saúde
José Pauli, Joseane Morari, Claudio De Souza, Juliana Moraes, Patrícia
Prada, Dioze Guadagnini, Rogrigo Marin, Alexandre Oliveira, Taize
Augusto, Hernandes F Carvalho, Mário Saad, Lício Velloso and José
Carvalheira. IL-6 and IL-10 Anti-inflammatory Activity Links Exercise to
Hypothalamic Insulin and Leptin Sensitivity through IKK? and ER Stress
Inhibition. Plos Biology, aceito para publicação.
2. Bruni-Cardoso A, Rosa-Ribeiro R, Pascoal VD, De Thomaz AA, Cesar
CL, Carvalho HF. MMP-2 regulates rat ventral prostate development in
vitro. Dev Dyn. 2010 239: 737-746.
3. MM Brandão; Barjas-Castro M L; Fontes A; Cesar CL; Costa F F; Saad
STO. Impaired red cell deformability in iron deficient subjects. Clinical
Hemorheology and Microcirculation, v. 43, p. 217-221, 2009
4. CORRÊA JR, J. D. ; Bruno, M.I. ; ALLODI, S. ; FARINA, M. . Effects of
H+ concentration on amorphous mineral granules: Structural stability
and elemental mobilization. S.Allodi e M.Farina contribuíram igualmente
para o trabalho. Journal of Structural Biology, v. 166, p. 59-66, 2009.
5. ZAMBUZZI, W. F.; Bruni-Cardoso Alexandre ; GRANJEIRO, J. M. ;
Peppelenbosch M.P. ; CARVALHO, H. F. ; AOYAMA, H. ; FERREIRA, C. V. .
On the road to understanding of the osteoblast adhesion: Cytoskeleton
organization is rearranged by distinct signaling pathways. Journal of
Cellular Biochemistry (Print), v. 108, p. 134-144, 2009.
Sandro Sendin Mitsuhiro (Vice-coordinator)
Ilana Pinsky
Sérgio Duailibi
Hamer Nastasy Palhares Alves
Neliana Buzi Figlie
Marcelo Ribeiro de Araújo
Cláudio Jerônimo da Silva
Main research topics
1. Prevalence of drink-driving in São Paulo (SP) and Belo Horizonte (MG).
2. The assessment of drug addicted individuals by the perspective of
their families.
3. “Addiction” Article.
4. International Symposium of public policy on alcohol and drug dependence.
5. Meeting of the Pan American Health Organization – PAHO.
6. Disclosure to the Media: books, interviews in newspapers and magazines,
and participation in television programs.
7. Chemical Dependency Specialization Courses.
8. Post-graduation program.
National Institute of Science and Technology of
Redox Processes in Biomedicine – Redoxoma
Management committee
Ohara Augusto (Coordinator)
Francisco R M Laurindo (Vice-coordinator)
Alícia J Kowaltowski
Luis Eduardo Soares Netto
Marisa Helena Gennari de Medeiros
Paolo Di Mascio
Associated Institutions
USP; UFRGS; UFAM; UNIFESP; UFPR; UFS; UFMG; UFRN; UNIFAL; UnB;
Instituto Butantan; UFF
Main researchers
Ohara Augusto, Francisco R M Laurindo, Alícia J Kowaltowski, Luis Eduardo
Soares Netto, Marisa Helena Gennari de Medeiros, Paolo Di Mascio,
Ana Maria da Costa Ferreira, Antonia Tavares do Amaral, Diego Bonatto,
Emerson Silva Lima, Etelvino José Henriques Bechara, Glaucia Regina
Martinez, Humberto Reis Matos, Leda Quércia Vieira, Lia Sumie Nakao,
Lucymara Fassarella Agnez Lima, Maísa Ribeiro Pereira Lima Brigagão,
Marcelo Hermes Lima, Marilene Demasi, Nadja Cristhina de Souza-
-Pinto, Pio Colepicolo, Roger Chammas, Sayuri Miyamoto, Vitor Francisco
Ferreira, Wilson da Costa Santos
Main publications
Cussiol JR, Alegria TG, Szweda LI, Netto LE. Ohr (organic hydroperoxide
resistance protein) possesses a previously undescribed activity: Lipoyl-
-dependent peroxidase. J Biol Chem. 2010 285:21943-50.
Horta BB, Oliveira MA, Discola KF, Cussiol JR, Netto LE. Structural and
biochemical characterization of peroxiredoxin Q beta from Xylella fastidiosa:
catalytic mechanism and high reactivity. J Biol Chem. 2010 285:16051-65.
Barbosa LF, Cerqueira FM, Macedo AF, Garcia CC, Angeli JP, Schumacher
RI, Sogayar MC, Augusto O, Carrì MT, Di Mascio P, Medeiros MH. Increased
SOD1 association with chromatin, DNA damage, p53 activation, and
apoptosis in a cellular model of SOD1-linked ALS. Biochim Biophys Acta.
2010 1802:462-471.
Kowaltowski AJ, de Souza-Pinto NC, Castilho RF, Vercesi AE. Mitochondria
and reactive oxygen species. Free Radic Biol Med. 2009 47:333-43.
Barea F, Bonatto D. Aging defined by a chronologic-replicative protein
network in Saccharomyces cerevisiae: an interactome analysis. Mech
Ageing Dev. 2009 130:444-60.
Wosniak J Jr, Santos CX, Kowaltowski AJ, Laurindo FR. Cross-talk between
mitochondria and NADPH oxidase: effects of mild mitochondrial dysfunction
on angiotensin II-mediated increase in Nox isoform expression and activity
in vascular smooth muscle cells. Antioxid Redox Signal. 2009 11:1265-78.
Contacts
Summary of achievements and perspectives
1. Prevalence of drink-driving in São Paulo (SP) and Belo Horizonte (MG):
2,077 people were interviewed and had their alcohol level measured.
Contacts
Instituto de Biologia - Unicamp
2. The assessment of drug addicted individuals by the perspective of their
Instituto de Química - Universidade de S. Paulo
Bloco N Sala 11
families: impact of drugs on the family and characteristics of consumption.
Cx.P. 26077; CEP 05513-970
Tel: (19) 3521 6118
3. “Addiction” Article: invitation of the editorial board of the journal
São Paulo, SP - Brazil
e-mail: hern@unicamp.br
“Addiction” to report the history and operation of UNIAD/INPAD.
Tel: (5511) 3091-3873; Fax: (5511) 3091-2186
http://www.inct-infabic.ib.unicamp.br/
4. International Symposium of public policy on alcohol and drug dependence:
Main research topics
redoxoma@iq.usp.br
participation of Professor Ralph Hingson, the coordinator of the NIAAA-USA.
1) Reactive oxygen species (ROS) generation and control; 2) Chemical http://www2.iq.usp.br/redoxoma/
5. Meeting of the Pan American Health Organization – PAHO: exchange
reactivity of ROS in biological environments and consequent changes in
information, paving the way for future international partnerships.
the structure and function of biomolecules; 3) Mechanisms and networks
6. Disclosure to the Media: publishing of 6 books and 8 participations in
involved in redox processes relevant to human diseases; and 4) Diagnostic
interviews in newspapers, television programs and magazines.
7. Chemical Dependency Specialization Courses: 51 students graduated
and therapeutic applications of redox processes.
from the chemical dependency counseling course and 123 students
Summary of achievements and perspectives
graduated from the chemical dependency specialization.
The core group of Redoxoma network started in the Program Institutes of
8. Post-graduation program: 1 doctoral thesis was completed and 3 other
the Millenium and acquired experience to make important contributions
ones are in the final stages and should be completed in the first half of 2011.
to advance the knowledge of the molecular basis of redox processes in
9. Perspectives: “Health economics: the cost of drinking and driving”;
the first year of the INCT. It is impossible to summarize the results obtai-
The second survey on patterns of alcohol consumption; Master’s degree
ned in 20 lines, but those that open new perspectives were highlighted in Tissue-, substrate- and site-specific characteristics of mitochondrial
in chemical dependency conducted through the internet.
our Annual Report (see, Annual Report in http://www2.iq.usp.br/redoxoma/).
With respect to biomarkers, it was developed a highly sensitive
reactive oxygen species generation
Main publications
fluorescent method for the detection of cholesterol aldehydes formed by
Highly reported prevalence of drinking and driving in Brazil: data from the
ozone and singlet molecular oxygen (Mansano et al, 2010, Anal Biochem,
first representative household study (Revista Brasileira de Psiquiatria-
submitted). In regard to antioxidant enzymes, new insights into the spe-
-RBP); Alcohol use patterns among Brazilian adults(RBP); Underreporting
cificity of thioredoxin reductase-thioredoxin interactions were provided
Structural elements in the squid shell identified by femtosecond laser
illumination
of use of cocaine and marijuana during the third trimester of gestation
among pregnant adolescents (Addictive Behaviors); Prevalence of cannabis
use in Brazil: Data from the I Brazilian National Alcohol Survey (Addictive
(Oliveira et al, Biochemistry 49, 3317, 2010). The generation of reactive
oxygen species by mitochondria was shown to be tissue-substrate- and
site-specific (Tahara et al, Free Radic Biol Med 46, 1283, 2010).With
National Institute of Science and Technology in
Stem Cell and Cell Therapy – INCTC
Behaviors); Intimate partner violence and contribution of drinking and
respect to biomolecule damage, it was shown that the recombination
sociodemographics: the Brazilian National Alcohol Survey (Journal of
protein RAD52 cooperates with the excision repair protein OGG1 for the Management committee
Interpersonal Violence); Highly reported prevalence of drinking and driving
repair of oxidative lesions in the DNA of mammalian cells (Souza-Pinto Roberto Passetto Falcão (Coordinator)
in Brazil: data from the first representative household study (RBP).
et al, Mol Cell Biol 29, 4441, 2009). Redox networks have started to be Dimas Tadeu Covas (Vice-coordinator)
National Institute of Science and Technology for
Policies on Alcohol and other Drugs – INPAD
Contatos
Rua Botucatu, 394
developed by defining aging as a chronologic-replicative protein network
in Saccharomyces cerevisiae (Barea and Bonatto Mech Ag Devel 13, 444,
2009).Therapeutic applications of redox processes was explored with the
Maria Angélica Miglino
Flávio Vieira Meirelles
Lygia Pereira Veiga
Vila Clementino - São Paulo – SP
non-classical antioxidant tempol that was shown to be effective in the
Management committee
Phone number: 55 11 5579 0640
treatment of multiple sclerosis in a mice model (Tsuhako et al, Free Radic Associated Institutions
Ronaldo Laranjeira (Coordinator)
www.uniad.org.br
Biol Med 48,704, 2010).
USP/Ribeirão Preto; UFRJ; IEC/PA; USP; CENP/PA
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