livro

Saúde INCT – Institutos Nacionais de Ciência e Tecnologia
INCT – Institutos Nacionais de Ciência e Tecnologia
Saúde
HeMoLab: Oscillatory Shear Index in patient-specific
carotid bifurcation
National Institute of Science and Technology of
Molecular Medicine – INCT-MM
Management committee
Marco A. Romano-Silva (Coordinator)
Marcus Vinicius Gomez (Vice-coordinator)
Luiz A. De Marco
Carlos Jorge Simal
Carlos Malamut
Associated Institutions
CDTN; FUNED; PUC-MG; UFMG; HJK; UFOP; UFSM; UNESC
Main researchers
Marco A. Romano-Silva, Marcus Vinicius Gomez, Alexei Manso Correa
Machado, Ana Cristina Simoes e Silva, Débora Marques de Miranda,
Humberto Correa, Leandro Malloy-Diniz, Márcia Mendonça Carneiro, Raquel
Gouvêa dos Santos, Teresa C. Abreu Ferrari, Viviane S. Parisotto Marino
Campus at UFMG, until December 2010. Another Unit of Positron Emission
Tomography, though aimed at animal research, was also acquired
and will be installed in the laboratory of radiobiology Development Center
of Nuclear Technology (CDTN). Combined with other structures already
available from the University, the creation of INCT-MM permitted the
closure of a chain of scientific production in the area of molecular medicine.
This is because the CDTN, who lacated at the Pampulha campus of
the University, created a facility for production of radiopharmaceuticals.
From the work done by the National Institute of Science and Technology
in Molecular Medicine, those substances, once produced and tested in
animals in CDTN may be efficiently evaluated clinically in the medical
school. Thus, the unity of CDTN will receive feedback that will help
develop more specific radiopharmaceuticals.
Main publications
Ferreira et al Journal of Affective Disorders, v. 112, p. 267-272, 2009 .
Miranda et al. Clinical Endocrinology 71(4):512-7
Miranda et al. Am J Med Genet B Neuropsychiatr Genet. 2009 Jun
5;150B(4):483-6.
Moreira et al. Journal of Oral Pathology and Medicine, v. 38, p. 99-103, 2009.
Navarro et al Progress in Neuro-Psychopharmacology & Biological
Psychiatry, 2009. 33(2):214-9.
Navarro et al. Progress in Neuro-Psychopharmacology & Biological
Psychiatry, 2009. 17;33(2):229-
Pereira et al. Current Genomics, 2009. 10:51-9.
Pereira et al. World J Gastroenterol. 2009 Jun 7;15(21):2579-86.
Pinheiro et al. Hippocampus. 2009
Sarquis et al. Surgery 145: 249-250
Silva, et al., Nephrology (Carlton), 2009; 14, p. 198-204.
Souza et al., Hum Psychopharmacol. 2009 Dec;24(8):676-9.
Souza et al. Int J Dev Neurosci. 2009 Feb;27(1):1-7.
Contacts
Av. Professor Alfredo Balena,
190 - sala 114 - Belo Horizonte – Minas Gerais - Brasil
CEP: 30.130-100
Telefone: 55 31 3409-9650
E-mail: medicinamolecular@medicina.ufmg.br
romano-silva@ufmg.br
Site: www.medicina.ufmg.br/molecular
National Institute of Science and Technology of
Obesity and Diabetes
Management committee
Mario José Abdalla Saad (Coordinator)
Rui Curi (Vice-coordinator)
Ângelo Raphael Carpinelli
Antonio Carlos Boschero
Regina Célia Santiago Moisés
Associated Institutions
UNICAMP; USP; UNIFESP
Main researchers
Aníbal Eugenio Vercesi; Lício Augusto Velloso; Kleber Gomes Franchini; José
Antônio Rocha Gontijo; Roger Frigério Castilho; José Barreto C. Carvalheira;
Patricia de Oliveira Prada; Eduardo Ropelle; Marcos Antonio Tambascia;
José Carlos Pareja; Bruno Geloneze; Everardo Magalhães Carneiro; Helena
Coutinho Franco de Oliveira; Ubiratan Fabres Machado; Fábio Bessa Lima;
Zuleica Bruno Fortes; José Cipolla Neto; Silvana Bordin; Carla R O Carvalho;
Maria Tereza Nunes; Sandra Roberta Ferreira; Sérgio A. Dib; Tânia Pithon-
-Curi; Sandro Hirabara; César Luis Boguszewiski; Roberto Barbosa Bazotte;
Ana Mayra de Oliveira; Renan Montenegro Jr; Luiz Fabrizio Stoppiglia;
Marcia Queiroz Latorraca; Maria Helena Gaíva Gomes da Silva; Maria
Salete Ferreira Martins; Marise Auxiliadora de Barros Reis; Roberto Vilela
Veloso; Vanessa Cristina Arantes
Main research topics
1) Clinical research in genetics, pathophysiology and treatment of obesity
and diabetes.
2) Basic research in areas related to molecular mechanisms in the control of
food ingestion and energy expenditure, adipocyte biology, molecular mechanisms
that control insulin secretion and action, molecular that control complications
of obesity and diabetes, by using metabolomics and proteomics.
3) Translational research in obesity and diabetes.
Summary of achievements and perspectives
The results obtained in the past year demontrate an important advance
in the mechanisms of obesity, diabetes and their complications as: a)
demonstration of the importance of intestinal microbiota in the development
of obesity, indicating potential mechanisms for drug development, b)
demonstration of new proteins and also for the role of exercise in the control
of food ingestion and energy expenditure. In this line we also demonstrated
in humans, by functional NMR subclinical inflammation in hypothalamus in
obesity; c) molecular mechanisms that control insulin secretions in animal
models of obesity and diabetes; d) mitochondrial dysfunction in animal
models of dyslipidemia and obesity; e) modulation of GLUTS in different tissues
in animal models of diabetes; f) the role of saturated and unsaturated
fatty acids in subclinical inflammation and insulin sensitivity.
In the past year, the researcher of the Institute published 198 papers in
journals with good impact factor and 3 books.
The perspectives are excellent and in the next year we will receive
equipment in to do mass spectrometry that will help us to have a faster
development in our research in metabolomics and proteomics.
T. Romanatto et al., J Biol Chem., 284, 36213 (2009).
M. F. Graciano et al., J Cell Physiol. (2010)
P. Newsholme et al., Diabetologia., 52, 2489 (2009).
A. D. Luchessi et al., Brain Res., 1228, 6 (2008)
H. S. Freitas et al., Endocrinology;149, 717(2008).
F. M. Giuffrida et al., Diabetes Care., 33, e80 (2010).
Contacts
Universidade Federal de São Paulo
Rua Botucatu, 862 - 04023-900 São Paulo, SP
Tel.: (11) 55492064; Fax: (11) 55739304
e-mails: esper@pq.cnpq.br;esper.nexp@epm.br
Centre of Diabetes – UNIFESP
National Institute of Science and Technology of
Papilomavirus Related Diseases – INCT-HPV
Management committee
Luisa Lina Villa (Coordinator)
Valdir Golin (Vice-coordinator)
Raimundo Raffaelli Filho
José Eluf Neto
Henrique O. de Olival Costa
Osmar Avanzi
Associated Institutions
FCMSCSP; ICMSCSP; ILPC; USP; Hospital de Barretos (Fundação Pio XI)
Main research topics
• Analysis of biological and medical imaging
Main researchers
• Clinical and molecular characterization of neuropsychiatric diseases
Luisa Lina Villa, Henrique O. de Olival Costa, Adhemar Longatto Filho,
• Pharmacogenomics / Pharmacogenetics
Ana Paula Lepique, Tsutomo Aoki, Enrique Boccardo, José Eduardo Levi,
• Neurotoxins as therapeutic agents
Karina Braga Ribeiro, Lia Mara Rossi, Maria Amélia M. Veras, Paulo Cesar
• Development of new radiopharmaceuticals
• Pediatric Nephrology
Maciag, Wilma de Carvalho Forte
• Neoplasms and proliferative diseases
Main research topics
1. Evaluation of HPV molecular tests in primary screening for cervical cancer:
Summary of achievements and perspectives
There is a consensus among experts, that the incorporation of tests for HPV
Up to now, the activities of the INCT-MM have been directed to installa-
based on nucleic acid technologies into cervical cancer screening programs
tion of the infrastructure and development of protocols. With the funding
from MCT / CNPq / FAPEMIG, the INCT-MM acquired a Positron Emission
The PETtrace is an integrated system of production of PET tracers
that comprise a negative ion cyclotron control system with a worksta-
Main publications
E. R. Ropelle et al., PLoS Biol. 8, (2010).
is advantageous, with improved detection of cervical cancers missed by
conventional cytological diagnosis. We will compare different methodologies
246
Tomography Unit for Human use, which will be installed at the Medical
tion operator, target systems and synthesis systems.
P. O. Prada et al., Diabetes, 58, 2910 (2009).
aiming to propose new strategies for cervical cancer screening in the country.
247