ÖSTROJEN RESEPTÖRÜ NEGATİF İNVAZİV MEME ...

Ç NDEK LER
1.G R VE AMAÇ .................................................................................. 1
2.GENEL B LG LER............................................................................... 3
2.1.TAR HÇE ................................................................................................................. 3
2.2.EMBR OLOJ ........................................................................................................... 4
2.3.ANATOM ................................................................................................................ 4
Memenin arterleri..................................................................................................... 5
Memenin sinirleri ..................................................................................................... 5
Memenin lenfatik direnajı ........................................................................................ 5
2.4.F ZYOLOJ VE H STOLOJ ................................................................................... 6
2.5.YEN PROGEN TÖR HÜCRE MODEL .......................................................... 7
2.6.MEME KANSER .................................................................................................... 10
nsidans ve Epidemiyoloji ........................................................................................ 10
WHO Sınıflaması...................................................................................................... 10
Etyoloji...................................................................................................................... 13
nvaziv meme karsinomu.......................................................................................... 14
nvaziv duktal karsinom...................................................................................... 14
nvaziv lobüler karsinom .................................................................................... 16
Tubuler karsinom................................................................................................ 17
nvaziv kribriform karsinom............................................................................... 18
Medüller karsinom.............................................................................................. 18
Müsin üreten karsinom ....................................................................................... 18
Nöroendokrin tümörler ....................................................................................... 18
nvaziv papiller karsinom ................................................................................... 18
nvaziv mikropapiller karsinom......................................................................... 19
Apokrin karsinom ............................................................................................... 19
Metaplastik karsinom.......................................................................................... 19
Prognostik parametreler.................................................................................................. 20
2.7.MEME KANSER SINIFLAMASINA YEN YAKLA IM VE
BAZAL BENZER MEME KARS NOMLARI...................................................... 28
3.MATERYAL-METOD.......................................................................... 34
Kullanılan antikorlar ................................................................................................ 35
HK Boyama yöntemi ve de erlendirme ................................................................ 36
statiksel De erlendirme .......................................................................................... 37
4.BULGULAR ........................................................................................... 38
5.TARTI MA ............................................................................................ 58
6.RES MLER............................................................................................. 65
7.SONUÇLAR ........................................................................................... 73
8.KAYNAKLAR........................................................................................ 75
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