4th EucheMs chemistry congress

thursday, 30-Aug 2012
s801
chem. Listy 106, s587–s1425 (2012)
organic Chemistry, Polymers – ii
frontiers and Advances of organic Chemistry – i
o - 4 8 8
new direCtionS in orGAnoCAtALySiS
K. A. JorGenSen 1
1 Aarhus University, Chemistry, Aarhus C, Denmark
The lecture will present new activation modes in
organocatalysis which allow for the development of new reaction
concepts
4 th EucheMs chemistry congress
frontiers and Advances of organic Chemistry – i
o - 4 8 9
MiCro fLow CheMiStry – new PoSSiBiLitieS
for SynthetiC CheMiStS
t. noeL 1 , S. BuChwALd 2 , v. heSSeL 1
1 Technische Universiteit Eindhoven, Chemistry and Chemical
Engineering, Eindhoven, Netherlands
2 Massachusetts Institute of Technology, Chemistry, Cambridge,
United States Pacific Island Wildli
Until recently, many reactions have been exclusively
performed in batch processes. With the advent of microfluidics,
significant effort has been devoted to develop a wide variety of
continuous-flow techniques to facilitate organic synthesis. [1, 2]
Microreactor technology offers several advantages compared to
traditional batch reactors, such as, enhanced heat- and masstransfer
and the possibility to integrate several reaction steps and
subsequent separations in a single streamlined process.
In this presentation, we will give an overview of some
interesting aspects of flow chemistry within the realm of so-called
Novel Process Windows. [3] This involves microflow results
obtained in:
• Buchwald-Hartwig Aminations: this section details on
handling of solid forming reactions in microfluidic
systems; [3a, 3e]
• Suzuki-Miyaura Cross-Coupling Reactons: the feasibility
to perform multistep reactions in microflow will be
described in this part; [3b, 3d]
• Pd-catalyzed Fluorinations: our efforts towards the
development of an accelerated fluorination process in flow
will be discussed in this fragment; [3c]
• Click chemistry: we will conclude with a discussion of
our efforts to develop a continuous copper scavenger
unit. [3f]
references:
1. T. Noel, S. L. Buchwald, Chem. Soc. Rev. 2011, 40, 5010.
2. V. Hessel, I. Vural-Gursel, Q. Wang, T. Noel, J. Lang,
Chem. Eng. Technol. 2012, in press.
3. a) T. Noel, J.R. Naber, R.L. Hartman, J.P. McMullen,
K.F. Jensen, S.L. Buchwald, Chem. Sci. 2011, 2, 287.
b) T. Noel, S. Kuhn, A.J. Musacchio, K.F. Jensen,
S.L. Buchwald, Angew. Chem. Int. Ed. 2011, 50, 5943.
c) T. Noel, T.J. Maimone, S.L. Buchwald, Angew. Chem.
Int. Ed. 2011, 50, 8900.
d) T. Noel, A.J. Musacchio, Org. Lett. 2011, 13, 5180.
e) S. Kuhn, T. Noel, L. Gu, P.L. Heider, K.F. Jensen, Lab
Chip 2011, 11, 2488.
f) A.C. Varas, T. Noel, Q. Wang, V. Hessel, 2012
manuscript in preparation.
Keywords: Microreactors; Amination; fluorine; Click
chemistry; Cross-coupling;
AUGUst 26–30, 2012, PrAGUE, cZEcH rEPUbLIc