4th EucheMs chemistry congress

tuesday, 28-Aug 2012
s839
chem. Listy 106, s587–s1425 (2012)
solid state Chemistry Materials chemistry/New materials
supramolecular Chemistry and Nanostructured Materials – iii
o - 2 5 0
MeSoPorouS And MiCroPorouS MAteriALS
for BioMediCAL APPLiCAtionS
L. de CoLA 1 , S. Kehr 1 , z. Li 1
1 Westfalische Wilhelms-Universitat Munster, Center for
Nanotechnology, Muenster, Germany
Porous materials such as zeolites L, and ordered mesoporous
silica systems are interesting containers which can reach small
dimensions and can with appropriate functionalization be
biocompatible. In this talk I will show that silica based materials
can be used to target label and kill antibiotic resistant bacteria
using light. The multifunctional nanocontainers can be used for
diagnostics purposes and their uptake by different type of cell
will be shown. The combination of imaging and deliver will be
demonstrated with a very recent result. Cellular uptake of
nano-size zeolites can be followed by fluorescence microscopy
and molecules entrapped inside the channels of the zeolites can
be delivered into the nucleus of the cells. Indeed the channels can
be opened upon degradation of a polymer used to coat the entire
crystals.
Finally the use of these silica materials for the patterning of
surfaces will be discussed. The pattern can be obtains using micro
contact printing and the functionalization with biomolecules will
lead to the cell adhesion only in desired patterns. The use of chiral
systems will allows the immobilization of only desired type of
cells.
4 th EucheMs chemistry congress
supramolecular Chemistry and Nanostructured Materials – iii
o - 2 5 1
CheMiCAL reACtionS of MoLeCuLAr CryStALS
And AGGreGAteS under hiGh PreSSureS
v. SChettino 1
1 Universita di Firenze, Dipartimento di Chimica, Sesto
Fiorentino Firenze, Italy
In the last years information on chemical reactions at high
pressures in molecular crystals and other molecular aggregates
has been growing steadily involving a variety of systems and
among others simple second row diatomics and triatomics,
hydrocarbons, energetic materials, alcohols, clathrate hydrates.
With the available data it is feasible to attempt a classification of
high pressure chemical reactions primarily into reversible and
irreversible processes depending of the free energy profile from
reactants to products and its modification going from ambient to
high pressures and the heigth of the enrgy barriers. In several
experiments and in ab initio molecular dynamics modeling the
role of excited electronic states in high pressure reactivity has
been highlighted and a novel dynamic view of the topochemical
principle has been brougth forward as a source of selectivity in
high pressure processes as a subsection of solid state chemistry.
The collective character of high pressure solid state reactions has
also been evidenced. The synergy of the combined use of
pressurization and photoactivation has been shown to be an
invaluable source of information on the the high pressure reaction
mechanisms.
These concepts will be discussed with results on high
pressure reactions in simple hydrocarbons (condensation,
polymerization, amorphization), on simple alcohols and on
clathrate hydrates.
references:
1. V.Schettino, R. Bini, M. Ceppatelli, L. Ciabini, M. Citroni
Adv. Chem. Phys. 131 (2005) 105
2. L. Ciabini, F. A Gorelli, M. Santoro, Roberto Bini,
V. Schettino, S. Raugei
Nature Mater. 6 (2007) 39
3. R. Bini, V. Schettino
Chem. Soc. Rev. 36 (2007) 869
4. M. Citroni, R. Bini, P. Foggi and V. Schettino
PNAS 105 (2008) 7658
5. M. Ceppatelli, R. Bini, V. Schettino
PNAS 106 (2009) 11454
6. S. Fanetti, M. Ceppatelli, M. Citroni, R.Bini
J. Phys. Chem. B, 115 (2011) 15236; 114 (2010) 15437
Keywords: high pressure chemistry; solid state chemistry;
photoactivation;
AUGUst 26–30, 2012, PrAGUE, cZEcH rEPUbLIc