4th EucheMs chemistry congress

Poster Session 2
s1246
chem. Listy 106, s257–s1425 (2012)
Poster session 2 - Nanochemistry, Nanotechnology
P - 0 7 6 7
SyntheSiS And ChArACterizAtion of
SeLeCtive SenSor nAnoPArtiCLeS for
MAGnetiC reSonAnCe iMAGinG
d. nordMeyer 1 , P. StuMPf 1 , d. GrÖGer 2 , f. PAuLuS 2 ,
r. hAAG 2 , A. SeMiSCh 3 , C. riChter 3 , A. hArtwiG 3 ,
J. dernedde 4 , r. MALz 5 , u. rAuCh-KrÖhnert 5 ,
J. SChnorr 6 , i. GeMeinhArdt 6 , M. tAuPitz 6 ,
C. GrAf 1 , e. rühL 1
1 Freie Universität Berlin, Biology Chemistry and Pharmacy
Institute of Chemistry and Biochemistry Physical and
Theoretical Chemistry, Berlin, Germany
2 Freie Universität Berlin, Biology Chemistry and Pharmacy
Institute of Chemistry and Biochemistry Organic Chemistry,
Berlin, Germany
3 Technische Universität Berlin, Institute of Food Technology
and Food Chemistry, Berlin, Germany
4 Charité – Universitätsmedizin Berlin, Institute of Laboratory
Medicine Clinical Chemistry Pathobiochemistry, Berlin,
Germany
5 Charité – Universitätsmedizin Berlin, Cardiovascular
Diseases, Berlin, Germany
6 Charité – Campus Mitte, Institute of Radiology, Berlin,
Germany
The aim of the present study is the synthesis of iron oxide
nanoparticles functionalized by hyperbranched sulfated
polyglycerols (a heparin analogue) on their surface. This leads to
antiinflamatory, antimetastatic, antiathereosclerotic, and
antiproliferativ effects in organisms and can accumulate in
infected biological tissue. These hyperbranched sulfated
polyglyceroles functionalized iron oxide nanoparticles might be
used as contrast agents in the magnetic resonance imaging. It is
found that the number of functionalizing groups in the
hyperbranched sulfated polyglycerol determines the stability of
the iron oxide nanoparticles. Measurements are performed in
different biological media, such as Dulbecco`s Modified
Minimum Medium (DMEM) and isotonic saline, where the
stability of the nanoparticles and aggregation is probed.
Additionally, cell viability studies are reported using human colon
cancer cells. These are incubated with hyperbranched sulfated
polyglycerol functionalized iron oxide nanoparticles, indicating
that the viability of the cells is increased. Surface plasmon
resonance (SPR) studies indicate that the hyperbranched sulfated
polyglyceroles functionalized iron oxide nanoparticles lead to an
inhibition of L-selectin binding. Finally, the binding of
hyperbranched sulfated polyglycerol functionalized iron oxide
nanoparticles to infected tissue is tested using a mice-model,
which is infected with viral induced myocarditis.
These results indicate that hyperbranched sulfated
polyglycerol functionalized iron oxide nanoparticles may be
suitable for being used as a contrast agent in the magnetic
resonance imaging.
Keywords: Nanoparticles; Inflammation; Inhibitors;
4 th EucheMs chemistry congress
P - 0 7 6 8
MoLeCuLAr eLeCtroniCS in SeLf-ASSeMBLed
And SoLid-StAte deviCeS
K. norGAArd 1 , t. Li 1 , t. JAin 1 , t. BJornhoLM 1
1 University of Copenhagen, Nano-Science Center &
Department of Chemistry, Copenhagen, Denmark
Molecular nanogap junctions have been the subject of
intense study for the last decade, and include a variety of
approaches, such as mechanically controlled break junctions,
electromigration and scanning probe techniques. Herein, we
report recent progress towards the fabrication of novel
self-assembled molecular electronics systems, including solidstate
devices [1, 2] and chemically prepared nanogap junctions [1] .
Self-assembled solid-state monolayer devices containing a
range of conjugated organic molecules have been realized
employing chemically derived graphene as a soft, transparent
top-contact. Additionally, the graphene can serve as a protecting
layer against monolayer degradation from evaporating a metallic
top electrode [1] . Finally, chemically prepared nanogaps between
gold nanostructures have been achieved in solution [3] and on
surfaces [4] with a variety of molecules trapped in the gaps,
providing a possible route towards large-scale fabrication of
(single) molecular devices.
references:
1. T. Li et al., Adv Mater 24 1333-1339 (2012)
2. Z. Wei et al, Langmuir 28 4016-4023 (2012)
3. T. Jain et al., J. Colloid Interface Sci T, 376, 83-90 (2012)
4. T. Jain et al., ACS Nano, DOI: 10.1021/nn204986y (2012)
Keywords: Molecular electronics; Self-assembly;
Nanostructures; Graphene;
AUGUst 26–30, 2012, PrAGUE, cZEcH rEPUbLIc