4th EucheMs chemistry congress

Poster Session 1
s982
chem. Listy 106, s587–s1425 (2012)
Poster session 1 - inorganic Chemistry
P - 0 2 4 2
CroSS-LinKinG of two-diMenSionAL MetAL
CyAnide networKSBy SoL-GeL ProCeSSinG
e. feLBerMAir 1 , u. SChuBert 1
1 Vienna University of Technology, Institute of Materials
Chemistry, Vienna, Austria
Ni2+ complexes with certain nitrogen-containing organic
ligands and various metal cyanides form two-dimensional
honeycomb-like analogues of Prussian Blue. The organic ligands
block the four equatorial coordination sites of Ni2+ and thereby
favour this geometrical structure.
So far, attention has mainly been directed at networks of
[Ni(cyclam)] 2+ (cyclam=1,4,8,11-tetraazacyclotetradecane) with
3- Fe(CN) [1, 2] 3- or W(CN)8 [3, 4] . Research has been focused on them
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because they possess interesting magnetic properties and
microporosity. This combination leads to their classification as
“magnetic sponges” [5] , which denotes materials that change their
magnetic behaviour when the solvent guest molecules are
removed.
We are investigating whether the magnetic properties of the
materials change upon embedding the two-dimensional sheet
structures in an amorphous gel. This is done by cross-linking the
layers by means of trialkoxysilylalkyl groups, which are
introduced by derivatising the organic blocking ligands, followed
by sol-gel processing. The obtained gels are analysed regarding
their structure (NMR, spectroscopic measurements, elemental
analysis) as well as functionality (magnetic susceptibility,
conductivity).
references:
1. Colacio, E. et. al. Chem. Commun. 1999, 987-988
2. Colacio, E. et. al. Inorg. Chem. 2001, 40, 4876-4883
3. Nowicka, B. et. al. Dalton Trans. 2011, 40, 3067-3073
4. Nowicka, B.; Rams, M.; Stadnicka, K.; Sieklucka, B.
Inorg. Chem. 2007, 46, 8123–8125
5. Kahn, O.; Larionova, J.; Yakhmi, J. V. Chem.–Eur. J.
1999, 5, 3443-3449
Keywords: cyanides; Magnetic properties; microporous
materials; Nickel; macrocyclic ligands;
4 th EucheMs chemistry congress
P - 0 2 4 3
SyntheSiS, ChArACterizAtion And
AntiProLiferAtive ACtivity of SoMe
trAnSition MetAL CoMPLexeS with 3-(2-(4-
-MethoxyPhenyLCArBAMothioyL)hydrA -
zinyL)-3-oxo-n-(thiAzoL-2-yL)ProPAnAMide
e. eL-zAhAny 1 , S. drweeSh 1 , A. eL-Seidy 1 , M. ALi 2 ,
B. ABdeL-wAhAB 3 , n. youSSef 1
1 National Research Centre, Inorganic chemistry, Giza, Egypt
2 National Research Centre, Biochemistry, Giza, Egypt
3 National Research Centre, Applied Organic Chemistry, Giza,
Egypt
The coordination chemistry of nitrogen-sulfur donor ligands
such as thiazole derivatives as well as their transition metal
complexes are well documented to have antifungal and
antibacterial properties, beside antitumor activity. The aim of
this work is to prepare and characterize a new thiazole ligand
3-(2-(4-methoxyphenylcarbamothioyl)hydrazinyl)-3-oxo-N-
-(thiazol-2-yl)propanamide h L and its complexes and to study
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its antitumor activity against the human breast cancer cell line
(MCF-7). h L structure was confirmed by elemental analysis, IR,
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mass and 1H NMR spectroscopy. h L complexes with Cu(II),
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V(IV), Co(II), Mn(II) and Ni(II) have been characterized by
elemental analyses, molar conductivities, spectral (UV-Vis, IR,
1H NMR, mass) as well as magnetic moment measurements
technique. The IR spectra suggest that H L acts as a uni-negative
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tetradentate or mono-anionic bidentate ligand. The molar
conductance measurements proved that all complexes are
non-electrolytes, except ni, Co and Cucomplexes behaved as
electrolytes. The results revealed that the complexes possess a
tetrahedral, square planar, square-pyramidal or octahedral
geometry. The newly synthesized complexes have been tested for
their antibacterial and antitumor activities. The effect of the new
compounds on proliferation of human breast adenocarcinoma cell
line MCF-7 showed that all studied compounds have anticancer
activity except Co and v complexes, where the synthesized
complexes have antitumor activity values more than that of the
free ligand. The smaller value of IC50 of ni complex than that of
the cisplatin would provide a new potential antitumor drug.
Keywords: transition metal complexes; antiproliferative
activity; thiazol derivatives;
AUGUst 26–30, 2012, PrAGUE, cZEcH rEPUbLIc