4th EucheMs chemistry congress

Poster Session 2
s1109
chem. Listy 106, s257–s1425 (2012)
Poster session 2 - Analytical Chemistry
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deterMinAtion of CAdMiuM By AdSorPtive
StriPPinG voLtAMMetry uSinG PyroCAteChoL
vioLet CheLAtinG AGent
A. AhMAd 1 , A. ALdABAh 1 , A. ALMAiuf 1
1 King Saud University, Chemistry, AlRiyadh, Saudi Arabia
The adsorptive collection of Cd (II) complex with
pyrocatechol violet ligand, coupled with the square wave
voltammetric technique, yields a very sensitive electroanalytical
procedure for the determination of cadmium in various industrial
samples. The optimized experimental conditions include:
supporting electrolyte (carbonate buffer), pH (9.5), pyrocatechol
violet concentration (1.5?10-5 moll-1 ), accumulation time (30 s),
accumulation potential (0.0 V), scan rate (200 mV s-1 ), pulse
amplitude (0.05 V) and SW frequency (50 Hz). The monitored
stripping voltammetric current was linear over the range of
7.5?10-8 –1.75?10-7 moll-1 and the detection limit was 0.66 ppb.
The relative standard deviation was calculated as 1.02% (n =10)
for 1?10-7 mol l-1 Cd(II) and the obtained electrochemical signal
was stabile for up to 120 minutes. Possible interferences by either
co-existing metal ions or other chelating agents were also
investigated. The applicability of the developed method for the
determination of Cd element was assessed by the analysis of
various industrial and environmental samples. The accuracy of
the obtained voltammetric analytical results was validated by
comparing with that obtained by atomic absorption spectrometry
and conducting the necessary statistical evaluation.
Keywords: Electrochemistry; Voltammetry; Cadmium;
4 th EucheMs chemistry congress
P - 0 4 9 5
deterMinAtion of PKA vALue of irinoteCAn
uSed for treAtMent of CoLoreCtAL CAnCer
By reverSed PhASe Liquid ChroMAtoGrAPhy
B. AKMeSe 1 , S. SAnLi 2 , n. SAnLi 2
1 Hitit University Faculty of Science and Arts, Chemistry,
Corum, Turkey
2 Usak University Faculty of Science and Arts, Chemistry, Usak,
Turkey
Email: bdhylcn@hotmail.com
Colorectal cancer, also called coloncancer or large bowel
cancerincludes cancerous growths in the colon, rectum and
appendix. It is the thirdmost common form of cancer and the second
leading cause of cancer-related deathin the Western world [1] .
Colorectal cancer is the third mostcommon form of cancer appears
in our country and it can also occur in everyage, but above the
90% of the patients are more than 40 years old [2] . Recently,
combined active drugs in the treatment of colorectal cancer was
usedbecause of more efficiently destroy the tumor cells in the
standard therapy forpatients. Irinotecanwhich is one of the drugs
for this purpose, an antineoplastic drug usedintravenously in the
treatment of advanced colorectal cancer. It is isolatedfrom
Camptotheca acuminata which issitotiksik a tree that grows in
China [3] .
The ionization constant is an importantphysico-chemical
parameter of a drug and the knowledge of this parameter is
offundamental importance in a wide range of applications and
research areas. Inthis study pK values of irinotecan were
a
determined and the effectof the mobile phase composition on the
ionization constant was studied bymeasuring the pK at different
a
acetonitrile-water mixtures, 35,40,45, 50 % (v/v) using LC-UV
method.
references:
1. A. S. Sameer, S. Abdullah, M. Z. Banday, N. Syeed,
M. A. Siddiqi,International Journal of Genetics
andMolecular Biology, 2010, 2(6), 101–111.
2. C. Smith and J. A. Butler, Diseases ofthe Colon & Rectum,
1989, 32, 843–846.
3. W. Zhang, G. E. Dutschman, X. Li, M. Ye, Y.C. Cheng,
Journal of Chromatography B,2009, 877, 3038–3044.
AUGUst 26–30, 2012, PrAGUE, cZEcH rEPUbLIc