4th EucheMs chemistry congress

Poster Session 1
s950
chem. Listy 106, s587–s1425 (2012)
Poster session 1 - inorganic Chemistry
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SyntheSiS, ChArACterizAtion And
AntiMiCroBiAL ACtivity of PALLAdiuM(ii)
CoMPLexeS with SoMe ALKyL eSterS of
(S,S)-ethyLenediAMine-n,n'-di-2-(3-MethyL)-
-ButAnoiC ACid
v. GLodJoviC 1 , r. GordAnA 1 , i. rAdoJeviC 2 ,
o. StefAnoviC 2 , L. CoMiC 2 , S. trifunoviC 1
1 Faculty of Science, Chemistry, Kragujevac, Serbia
2 Faculty of Science, Biology, Kragujevac, Serbia
Numerous complexes based on palladium(II) ion have been
synthesized and their different biological activities have been
documented [1–2] . The impact of different palladium complexes on
the growth and metabolism of various groups of microorganisms
has been studied. Garoufis reviewed numerous scientific papers
on antiviral, antibacterial and antifungal activity of palladium(II)
complexes with different types of ligands [3] .
Palladium(II) complexes with R -S,S-eddp ligands
2
(S,S-eddp=(S,S)-ethylenediamine-N,N’-di-2-propanoate; R=n-pr,
n-bu, n-pe [4] were synthesized and characterized.
Three new ligand precursors and their palladium(II)
complexes of general formula [PdCl{(S,S)-(R)eddv}]
(R = n-propyl, n-butyl and n-pentyl; S,S-eddv =(S,S)-
-ethylenediamine-N,N’-di-2-(3-methyl)-butanoate) have
been synthesized and characterized by microanalysis, infrared,
1 13 H and C NMR spectroscopy and mass spectrometry. In vitro
antimicrobial activity for these ligands and complexes is
investigated. Testing is preformed by microdilution method and
minimum inhibitory concentration (MIC) and minimum
microbicidal concentration (MMC) have been determined. Testing
is conducted against 15 microorganisms (five strains of
pathogenic bacteria, three species of probiotic bacteria, two yeast
species and five pathogenic fungi). Tested ligands, with a few
exceptions, show very low antimicrobial activity. Palladium(II)
complexes show selective and moderate activity. The difference
in antimicrobial activity between ligands and corresponding
palladium(II) complexes is noticed and it is always higher with
palladium(II) complexes.
Acknowledgements: The authors are grateful to the Ministry of
Education and Science of the Republic of Serbia for financial
support.
references:
1. B.T. Khan, J. Bhatt, K. Najmoddin, S. Shamsuddin,
K. Annapoorna, J. Inorg. Biochem. 44 (1991) 55.
2. C. Navarro-Eanninger, J.M. Peréz, F. Zamora, V.M.
Gonzáles, J.M. Masaguer, C.Alonso, J.Inorg. Biochem.
52 (1993) 37.
3. A. Garoufis, S.K. Hadjikakou, N. Hadjiliadis, Coord.
Chem. Rev. 253 (2009) 1384.
4. G.P. Vasic, V.V. Glodovic, I.D. Radojevic, O.D. Stefanovic,
Lj.R. Comic, V.M. ?inovic, S.R. Trifunovic, Inorg. Chim.
Acta 363 (2010) 3606.
Keywords: Palladium; N ligands; Antifungal agents;
4 th EucheMs chemistry congress
P - 0 1 7 9
noveL diethAnoLAMine derivAtiveS of
AntiMony And BiSMuth- SyntheSiS And
StruCtureS
v. ABeyAwArAthAn 1 , C. dietz 1 , K. JurKSChAt 1
1 TU Dortmund, Anorganische Chemie II, Dortmund, Germany
In analogy to the 5-aza-2,8-dioxa-1-stanna(III)bi -
cyclo[3.3.01.5 ]octanes known as intermediates for the synthesis [1]
of non-toxic catalysts for polyurethane formation [2] ,
5-aza-2,8-dioxa-1-stiba(III)bicyclo[3.3.0 1.5 ]octanes of the type
XSb(OCR CH ) NR'(R=H, Me, R'= alkyl, aryl, X = Cl, F, N ) 2 2 2 3 [3]
and new pseudostibatranes were synthesized. The latter
compound shows an intramolecular MeO?Sb interaction
at a O-Sb distance of 3.12 ?. The antimony salt
{[Sb(OCMe CH ) NMe]GaCl } , which is isoelectronic to the
2 2 2 4 2
5-aza-2,8-dioxa-1-stanna(III)bicyclo[3.3.0 1.5 ]octanes mentioned
above, shows a dimeric structure. The 5-aza-2,8-dioxa-1-
-bismuta(III)bicyclo[3.3.01.5 ]octanes are dimeric structures in the
solid state. The interaction of compound 2 with moisture provided
a partial hydrolysis product that shows an interesting structure
with two bismuth atoms.
references:
1. T. Berends, L. Iovkova, G. Bradtmöller, I. Oppel,
M. Schürmann, K. Jurkschat, Z. Anorg. Allg. Chem. 2009,
635, 369.
2. J. Krause, S. Reiter, S. Lindner, A. Schmidt, K.Jurkschat,
M. Schürmann, G. Bradtmöller, Patent: DE 10 2008 021
980 Al.
3. V.Abeyawarathan, Master Thesis 2010, TU Dortmund.
Keywords: Diethanolamines; Antimony; Bismuth; Catalysis;
AUGUst 26–30, 2012, PrAGUE, cZEcH rEPUbLIc