4th EucheMs chemistry congress

Poster Session 2
s1111
chem. Listy 106, s257–s1425 (2012)
Poster session 2 - Analytical Chemistry
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fLuoreSCenCe deteCtion of nuCLeotideS
under PhySioLoGiCAL ConditionS uSinG
CoPPer(ii)-CoMPLexeS
r. ArnoLd 1 , n. BACKMAnn 1 , e. KAtAev 1
1 Chemnitz University of Technology, Organic Chemistry,
Chemnitz, Germany
Detecting anionic species of biological importance like
phosphates with the help of chemosensors has attracted
considerable attention in recent years. [1] Especially high selective
receptors for adenine containing nucleotides are of particular
interest. [2]
Herein we present a novel approach for fluorescent sensing
of nucleotides based on designing the ligands that not only contain
fluorescent dyes but also a recognition site for metal ions like
copper(II) which are known for strong interactions with
phosphates. Together with analytes these ligands can form ternary
copper(II)-complexes in aqueous solution.
The ligand works as key component that determines the
selectivity and generate an analytical signal. We synthesized
ligands 1-4 which in the presence of copper(II)-salts showed
moderate selectivity for ATP and GTP according to fluorescence
measurements. The recognition mechanism for each ligand was
investigated. It was shown that selectivity can be achieved using
a combination of several ligands with copper(II)-salts.
references:
1. a) A. E. Hargrove, S. Nieto, T. Z. Zhang, J. L. Sessler, E.
V. Anslyn, Chem. Rev., 2011, 111, 6603–6782;
b) M. Wenzel, J. R. Hiscock, P. A. Gale, Chem. Soc. Rev.,
2012, 41, 480–520.
2. D. C. Liemburg-Apers, H. Imamura, M. Forkink, M.
Nooteboom, H. G. Swarts, R. Brock, J. A. M. Smeitink, P.
H. G. M. Willems, W. J. H. Koopman, Pharm. Res-Dord.,
2011, 28,2745 – 2757.
Keywords: Fluorescence; copper; nucleotides; sensor;
4 th EucheMs chemistry congress
P - 0 4 9 9
oPtiMizAtion of SodiuM BiCArBonAte
ProduCtion froM BorAx By tAGuChi Method
A. M. ASLAndAS 1 , M. CoPur 2 , y. onGAner 1
1 Atatürk University, Chemistry, Erzurum, Turkey
2 Atatürk University, Chemical Engineering, Erzurum, Turkey
The demand for boron products of industrial companies in
the world are increasing every passing day. Turkey has about 72 %
of the known boron reserves of the world. An important part of
Turkey’s boron reserves is occurred colemanite, tincal and ulexite
minerals. It is of great importance that variety of boron
compounds produced from boron minerals have increased and
that compounds have produced in minimum cost. Tincal is
dissolved in hot water and is separated from impurities by
filtration and is obtained as borax decahydrate (borax). Although
there are many studies concerned with the production of different
boron chemicals from borax, the studies with regard to sodium
bicarbonate from borax are scarcely available.
In this study, the sodium bicarbonate production from borax
decahydrate in ammonia solutions saturated by carbon dioxide
gas in pressure reactor was studied and the effects of relevant
parameters, namely; reaction temperature, solid-to-liquid ratio,
reaction time, pressure and ammonia concentration have been
investigated on the sodium bicarbonate production from borax by
using the Taguchi method. The chosen experimental parameters
were as follows: reaction temperature, 45–60 °C; solid-to-liquid
ratio, 0.69-0.92 g/mL; reaction time, 30- 60 min; pressure,
5-20 bar; ammonia concentration, 2,82-5,65 M. Steering speed
was stable at 500 rpm. The optimum conditions have been
determined between the sodium bicarbonate production efficiency
from borax and relevant parameters by means of variance analysis
by using the statistical computer software. The optimum
conditions were found to be as follows: reaction temperature,
60°C; solid-to-liquid ratio, 0.77 g/mL; reaction time, 50 min;
pressure 20 bar; ammonia concentration 3.7634 M. In these
conditions, produced sodium bicarbonate has approximately to
70% efficiency and 98% purity.
Keywords: Boron; High-pressure chemistry; Industrial
chemistry; Solid-phase synthesis; Carbon dioxide;
AUGUst 26–30, 2012, PrAGUE, cZEcH rEPUbLIc