Drug Targeting Organ-Specific Strategies

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Young-Sook Kang Physiology and Pathophysiology Laboratory College of Pharmacy Sookmyung Women’s University Chungpa-dong 2 ga 53-12 Yongsan gu, 140-742 Seoul Korea yskang@sookmyung.ac.kr Yukio Kato University of Tokyo Graduate School of Pharmaceutical Sciences 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 kato@seizai-nl.f.u-tokyo.ac.jp Robbert J. Kok Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery Ant. Deusinglaan 1 9713 AV Groningen the Netherlands r.j.kok@farm.rug.nl Jos G. W. Kosterink University Hospital Groningen Department of Hospital and Clinical Pharmacy Hanzeplein 1 9713 GZ Groningen the Netherlands j.g.w.kosterink@apoth.azg.nl Lou F. M. H. de Leij List of Contributors XI Groningen University Institute for Drug Exploration (GUIDE) Department of Pathology and Laboratory Medicine Medical Biology Section Tumor Immunology Laboratory Hanzeplein 1 9713 GZ Groningen the Netherlands l.f.m.h.de.leij@med.rug.nl Claudia S. Leopold University of Leipzig Department of Pharmaceutical Technology Schönauer Str. 160 04207 Leipzig Germany cleopold@rz.uni-leipzig.de Dirk K. F. Meijer Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery Ant. Deusinglaan 1 9713 AV Groningen the Netherlands d.k.f.meijer@farm.rug.nl Barbro N. Melgert Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery Ant. Deusinglaan 1 9713 AV Groningen the Netherlands b.melgert@farm.rug.nl
XII List of Contributors Grietje Molema Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery and Department of Pathology and Laboratory Medicine Medical Biology Section Tumor Immunology Laboratory Ant. Deusinglaan 1 9713 AV Groningen the Netherlands g.molema@farm.rug.nl Frits Moolenaar Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery Ant. Deusinglaan 1 9713 AV Groningen the Netherlands f.moolenaar@farm.rug.nl Ricardo Mutuberria Maastricht University Department of Pathology PO Box 616 6200 MD Maastricht the Netherlands Peter Olinga Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery Ant. Deusinglaan 1 9713 AV Groningen the Netherlands p.olinga@farm.rug.nl Klaas Poelstra Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery Ant. Deusinglaan 1 9713 AV Groningen the Netherlands k.poelstra@farm.rug.nl Johannes H. Proost Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery Ant. Deusinglaan 1 9713 AV Groningen the Netherlands j.h.proost@farm.rug.nl S. Ramakrishnan University of Minnesota Health Science Center Department of Pharmacology 321 Church Street Minneapolis Minnesota 55455 USA sunda001@maroon.tc.umn.edu
Page 1 and 2: Drug Targeting Organ-Specific Strat
Page 5 and 6: Preface Drug Targeting Organ-Specif
Page 7 and 8: Foreword Drug Targeting Organ-Speci
Page 9: X List of Contributors Henderik W.
Page 13 and 14: Contents Drug Targeting Organ-Speci
Page 15 and 16: Contents XVII 3 Pulmonary Drug Deli
Page 17 and 18: Contents XIX 5.2.1.6 Identification
Page 19 and 20: Contents XXI 7.5 In Vitro Technique
Page 21 and 22: Contents XXIII 9.4 Tumour Vasculatu
Page 23 and 24: Contents XXV 12.8. Tissue Slices fr
Page 27 and 28: Dexa dexamethasone DIVEMA divinyl e
Page 29 and 30: LRP lung resistance related protein
Page 31 and 32: ROS reactive oxygen species RSV res
Page 33 and 34: Index a ADEPT 217, 224, 268, 291 ad
Page 35 and 36: e E. coli expression system 292 eff
Page 37 and 38: polymers, soluble 4, 218 - dendrime
Page 39 and 40: 2 1 Drug Targeting: Basic Concepts
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24 2 Brain-Specific Drug Targeting
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54 3 Pulmonary Drug Delivery: Deliv
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4 Cell Specific Delivery of Anti-In
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The sinusoids are lined by the disc
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4.2.2.2 Phagocytosis and Transcytos
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ther inflammatory cells or accessor
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4.3 Hepatic Inflammation and Fibros
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process is not yet available. Sever
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this carrier to the KCs.When the ma
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e taken up rapidly by mannose recep
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y the transcriptional regulatory pr
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4.8 Testing Liver Targeting Prepara
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4.8 Testing Liver Targeting Prepara
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4.9 Targeting of Anti-inflammatory
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4.9 Targeting of Anti-inflammatory
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with monoclonal and bispecific anti
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References 117 [50] Coleman DL, Eur
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References 119 [133] Cronstein BN,
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5 Delivery of Drugs and Antisense O
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5.1 Introduction 123 convoluted tub
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treatment of the targeted cell and
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CL uptake (ml/min/g) centration pro
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5.2.1.4 Specific Binding of Alkylgl
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5.2 Renal Delivery Using Pro-Drugs
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5.2 Renal Delivery Using Pro-Drugs
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5.3 Renal Delivery Using Macromolec
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5.4 Renal Delivary of Antisense Oli
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5.4 Renal Delivery of Antisense Oli
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5.4.8 Benefits and Limitations of A
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via reabsorption from the luminal s
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References 153 [66] Franssen EJF, M
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References 155 [145] Van Zwieten PA
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158 6 A Practical Approach in the D
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172 7 Vascular Endothelium in Infla
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8 Strategies for Specific Drug Targ
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8.2.2 Histogenesis The traditional
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may become obstructed and compresse
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8.5 Strategies to Deliver Drugs to
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8.5 Strategies to Deliver Drugs to
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larly cytotoxic immune effector cel
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contributes to limited tumour penet
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ples onto anti-EGP-2 scFv. Biologic
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In the case of drug-monoclonal anti
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cells, the presence of co-stimulato
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Monomethoxy-polyethylene glycol CH
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e efficiently loaded into the lipos
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8.6 Clinical Studies 223 Table 8.5.
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8.6.3 (Synthetic) (co)Polymers Solu
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8.8 Conclusions and Future Perspect
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References 229 [43] Chaouchi NA, Va
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References 231 [126] Czuczman MS, G
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234 9 Tumour Vasculature Targeting
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256 10 Phage Display Technology for
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11 Development of Proteinaceous Dru
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carrier is an homogenous product. I
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11.3 The Homing Device 11.3 The Hom
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malian cell lines that have acquire
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jugates for the delivery of other a
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11.5 The Linkage Between Drug and C
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actions are directed towards these
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11.5 The Linkage Between Drug and C
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homing potential if the antigen rec
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ly used promoters include T7 RNA po
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the baculovirus expression vector,
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11.8 Recombinant DNA Constructs 297
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11.8 Recombinant DNA Constructs 299
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toxic activity. Anthrax and tetanus
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11.9 Recombinant Domains as Buildin
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References 305 [16] Milstein C, Wal
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References 307 [99] Verma R, Boleti
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12 Use of Human Tissue Slices in Dr
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are also extensively used in a vari
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Meanwhile many incubation systems h
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12.3 Incubation and Culture of Live
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to investigate the effect of differ
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The mechanisms of uptake and excret
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12.6 The Use of Liver Slices in Dru
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12.7 Efficacy Testing of the Drug T
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NO x µM 80 60 40 20 * * 12.7 Effic
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TNFα ng/ml 1.5 1 0.5 0 * Human (n=
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References 329 [33] Ikejima K, Enom
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References 331 [109] Dutt A, Priebe
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334 13 Pharmacokinetic/Pharmacodyna
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372 14 Drug Targeting Strategy: Scr
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374 14 Drug Targeting Strategy: Scr
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Drug Targeting Organ-Specific Strategies

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