230 8 <strong>Strategies</strong> for <strong>Specific</strong> <strong>Drug</strong> <strong>Targeting</strong> to Tumour Cells [85] Leenders RGG, Damen EWP, Bijsterveld EJA, Scheeren HW, Houba PHJ, van der Meulen- Muileman IH, Boven E, Haisma HJ, Bioorg. Med. Chem. Lett. 1999, 718, 1597–1610. [86] Bosslet K, Straub R, Blumrich M, Czech J, Gerken M, Sperker B, Kroemer HH, Gesson JP, Koch M, Monneret C, Cancer Res. 1998, 58, 1195–1219. [87] Bosslet K, Czech J, Hoffman D, Tumour Target. 1995, 1, 45–50. [88] de Groot FMH, de Bart ACW, Verheijen JH, Scharen HW, J. Med. Chem. 1999, 42, 5277–5283. [89] Takakura Y, Hashida M, Crit. Rev. Oncol. Hematol. 1995, 18, 207–231. [90] Duncan R, Spreafico F, Clin. Pharmacokinet. 1994, 27, 290–306,. [91] Duncan R, Anti-Cancer <strong>Drug</strong>s 1992, 3, 175–210. [92] Sezaki H, Takakura Y, Hashida M, Adv. <strong>Drug</strong> Delivery Rev. 1989, 3, 247–266. [93] Seymour LW, CRC Crit. Rev. Ther. <strong>Drug</strong> Carrier. Syst. 1992, 9, 135–187. [94] Vasey PA, Kaye SB, Morrison R, Twelves C, Wilson P, Duncan R, Thomson AH, Murray LS, Hilditech TE, Murray T, Burtles S, Fraier D, Frigerio E, Cassidy J, Clin. Cancer Res. 1999, 5, 83–94. [95] Lasic DD, Papahadjopoulos D, Science 1995, 267, 1275–1276. [96] Gregoriadis G, Trends Biotechnol. 1995, 13, 527–537. [97] Lasic DD, From Physics to Applications. Elsevier, Amsterdam, 1993. [98] Lasic DD, Martin FJ, (Eds) Stealth Liposomes. CRC, Boca Raton, FL, 1995. [99] Daemen T, Regts J, Meesters M, Ten Kate MT, Bakker-Woudenberg IAJM, Scherphof GL, J. Control. Rel. 1997, 44, 1–9. [100] Doroshaw JH, Cancer Chemotherapy and Biotherapy: Principles and Practice. (eds Chabner BA and Longo DL) pp. 409–433. Lippincott-Raven, Philadelphia, PA. 1996. [101] Harrigan PR, Wong KF, Redelmeier TE, Wheeler JJ, Cullis PR, Biochim. Biophys. Acta 1993, 1149, 329–338. [102] Cullis PR, Hope MJ, Bally MB, Madden TD, Mayer LD, Fenske DB, Biochem. Biophys. Acta 1997, 1331, 187–211. [103] Park JW, Hong K, Kirpotin DB, Meyer O, Papahadjopoulos D, Benz CC, Cancer Lett. 1997, 118, 153–160. [104] Crosasso P, Brusa P, Dosio F, Arpicco S, Pacchioni D, Schuber F, Cattel L, J Pharm. Sci. 1997, 86, 832–839. [105] Tseng YL, Hong RL, Tao MH, Chang FH, Int. J. Cancer 1999, 80, 723–730. [106] Kirpotin D, Park JW, Hong K, Zalipsky S, Li WL, Carter P, Benz CC, Papahadjopoulos D, Biochemistry 1997, 36, 66–75. [107] Lopes de Menezes DE, Pilarski LM, Allen TM, Cancer Res. 1998, 58, 3320–3330. [108] Killion JJ, Fidler IJ, Pharmacol. Ther. 1998, 78, 141–154. [109] Dass CR, Walker TL, DeCruz EE, Burton MA, <strong>Drug</strong> Deliv. 1997, 4, 151–165. [110] Li S, Huang L, Gene Therapy 1997, 4, 891–900. [111] Kaneda Y, Saeki Y, Morischita R, Mol. Med. Today 1999, 5, 298–303. [112] Mayer LD, Cancer Metast. Rev. 1998, 17, 211–218. [113] Drummond DC, Meijer O, Hong K, Kirpotin DB, Papahadjopoulos D, Pharmacol. Rev. 1999, 51, 691–743. [114] Brown SL, Miller RA, Levy R, Semin. Oncol. 1989, 16, 199–210. [115] Dillman RO, J. Clin. Oncol. 1994, 12, 1497–1515. [116] Renner C, Trümper L, Pfreundschuh M, Leukaemia 1997, 11, S55–S59. [117] Irie RF, Morton DL, Proc. Natl Acad. Sci. USA 1986, 83, 8694–8698. [118] Cheung N-KV, Lazarus H, Miraldi FD, Abramowsky CR, Kallick S, Saarinen UM, Spitzer T, Strandjord SE, Coccia PF, Berger NA, J. Clin. Oncol. 1987, 51, 430–1440. [119] Vadhan-Raj S, Cordon-Cardo C, Carswell E, Mintzer D, Dantis L, Duteau C, Templeton MA, Oettgen HF, Old LJ, Houghton AN, J. Clin. Oncol. 1988, 6, 1636–1648. [120] Handgretinger R, Baader P, Dopfer R, Klingebiel T, Reuland P, Treuner J, Reisfeld RA, Niethammer D, Cancer Immunol. Immunother. 1992, 35, 199–204. [121] Saleh MN, Khazaeli MB, Wheeler RH, Dropcho E, Liu T, Urist M, Miller DM, Lawson S, Dixon P, Russell CH, LoBuglio A, Cancer Res. 1992, 52, 4342–4347. [122] Riethmuller G, Holz e, Schlimok G, Schmiegel W, Raab R, Hoffken K, Gruber R, Funke I, Pichlmaier H, Hirche H, J. Clin. Oncol. 1998, 16, 1788–1794. [123] Oosterwijk E, Debruyne FMJ, Schalken JA, Semin. Oncol. 1995, 22, 34–41. [124] Weiner LM, Semin. Oncol. 1999, 26, 41–50. [125] McLaughlin P, Grillo-Lopez AJ, Link BK, Levy R, Czuczman MS, Williams ME, Heyman MR, Bence-Bruchler I, White CA, Canabillas F, Jain V, Ho AD, Frister J, Wey K, Shen D, Dallaize BK, J. Clin. Oncol. 1998, 16, 2824–2833.
References 231 [126] Czuczman MS, Grillo-Lopez AJ, White CA, Saleh M, Gordon L, LoBuglio AF, Jonas C, Klippenstein D, Dallaize B, Warms C, J. Clin. Oncol. 1999, 26, 268–276. [127] Dyer MJS, Semin. Oncol. 1999, 26, 52–57. [128] Baselga J, Tripathy D, Mendelsohn J, Baughman S, Benz CC, Dantis L, Shlarin NT, Seidman AD, Hudis CA, Moore J, Rosen PP, Twaddell T, Henderson IC, Norton L, J. Clin. Oncol. 1996, 14, 737–744. [129] Pegram MD, Lipton A, Hayes DF, Weber BL, Baselga MM, Tripathy D, Baly D, Baighman SA, Twaddell T, Glaspy JA, Slalom DJ, J. Clin. Oncol. 1998, 16, 2659–2663. [130] Baselga J, Tripathy D, Mendelsohn J, et al., Semin. Oncol. 1999, 26, 78–83. [131] Sievers EL, Appelbaum FR, Spielberger RT, Forman SJ, Flowers D, Smith FO, Shannon-Dorcy K, Berger MS, Berstein ID, Blood, 1999, 93, 3678–3684. [132] Saleh MN, LoBuglio AF, Trail PA, In: Monoclonal Antibody-Based Therapy of Cancer (Ed. Grossband M), pp. 397–416. Marcel Dekker, New York, 1998. [133] Tolcher AW, Sugarman S, Gelmon KA, Cohen R, Saleh M, Isaacs C, Young L, Healey D, Onetto N Slichenmyer W, J. Clin. Oncol. 1999, 17, 478–484. [134] Kaminski MS, Zasadny KR, Francis IR, Fenner MC, Ross CW, Milik AW, Estes J, Tude M, Regan D, Fisher S, Glenn SD, Wahl RL, J. Clin. Oncol. 1996, 14, 1974–1981. [135] Press OW, Eary JF, Appelbaum FR, Martin PJ, Badger CC, Nelp WB, Glenn S, Butchko G, Fisher D, Porter B, N. Engl. J. Med. 1993, 329, 1219–1224. [136] Press OW, Eary JF, Appelbaum FR, Martin PJ, Nelp WB, Glenn S, Fisher DR, Porter B, Matthews DC, Gooley T and Bernstein ID, Lancet 1995, 346, 336–340. [137] Liu SY, Eary JF, Petersdorf SH, Martin PJ, Maloney DG, Appelbaum FR, Matthews DC, Bush SA Duracke LD, J. Clin. Oncol. 1998, 16, 3270–3278. [138] Matthews DC, Appelbaum FR, Eary JF, Fischer DR, Durack LD, Hui TE, Martin PJ, Mitchell D, Press OW, Storb R, Bernstein ID, Blood 1999, 94, 1237–1247. [139] De Gast GC, Haagen IA, van Houten AA, Klein SC, Duits AJ, de Weyer RA, Vroom TM, Clark MR, Phillips J, Van Dijk AJ, Cancer Immunol. Immunother. 1995, 40, 390–396. [140] Janssen RAJ, Kroesen BJ, Buter J, Mesander G, Sleijfer DT, The TH, Mulder NH, de Leij L, Br. J. Cancer 1995, 72, 795–799. [141] Kroesen BJ, Nieken J, Sleijfer DT, Molema G, de Vries EGE, Groen HJM, Helfrich W, The TH, Mulder NH, de Leij L, Cancer Immunol. Immunother. 1997, 45, 203–206. [142] Valone FH, Kaufman PA, Guyre PM, Lewis LD, Memoli V, Deo Y, Graziano R, Fisher JL, Meyer L, Mrozek–Orlowski M, Wardwell K, Guyre V, Morley TL, Arvinu C, Fanger MW, J. Clin. Oncol. 1995, 13, 2281–2292. [143] Weiner LM, Clark JI, Davey M, Li WS, Garcia de Palazzo I, Ring DB, Alpaugh RK, Cancer Res. 1995, 55, 4586–4593. [144] Martin J, Stribbling SM, Poon GK, Begent RH, Napier M, Sharma SK, Springer CJ, Cancer Chemother. Pharmacol. 1997, 40, 189–201. [145] Fuertges F, Abuchowski A, J. Control. Rel. 1990, 11, 139–148. [146] Ho DH, Brown NS, Yen A, Holmes R, Keating M, Abuchowski A, Newman RA, Kozahoff IH, <strong>Drug</strong> Metab. Dispos. 1986, 14, 349–352. [147] Meyers FJ, Paradise C, Scudder SA, Goodman G, Konrad M, Clin. Pharmacol. Ther. 1991, 49, 307–313. [148] Martin FJ, Medical Applications of Liposomes (Eds frasic DD and Papahadjopoulos D) pp. 635–688, Elsevier, Amsterdam, 1998. [149] Eckhardt JR, Campbell E, Burris HA, Wiess GR, Rodriguez GI, Fields SM, Thurman AM, Peacock NW, Cobb P, Rothenberg ML, Ross ME, Von Hoff DD, Am. J. Clin. Oncol. 1994, 17, 498–501. [150] Gill PS, Espina BM, Muggia F, Cabriales S, Tulpule A, Esplin JA, J. Clin. Oncol. 1995, 13, 996–1003. [151] Valero V, Buzdar AU, Theriault RL, Azarnia N, Fonseca GA, Willey J, Ewer M, Walter RS, Mackay B, Podoloff D, Booser D, Lee LW, Hortobagyi GN, J. Clin. Oncol. 1999, 17, 1425–1434. [152] McLaughlin PMJ, Kroesen BJ, Dokter HA, van der Molen H, de Groot M, Brinker MGL, Kok K, Ruiters MHJ, Buys CHCM, de Leij LFMH, Cancer Immunol. Immunother. 1999, 48, 303–311. [153] Clynes RA, Takechi Y, MoroiY, Houghton A, Ravetch JV, Proc. Natl Acad. Sci. USA 1998, 95, 652–656. [154] Clynes RA, Towers TL, Persta LG, Ravetch JV, Nature Med. 2000, 6, 443–446. [155] Houghton AN, Scheinberg DA, Nature Med. 2000, 6, 373–375.
- Page 1 and 2:
Drug Targeting Organ-Specific Strat
- Page 3 and 4:
Drug Targeting Organ-Specific Strat
- Page 5 and 6:
Preface Drug Targeting Organ-Specif
- Page 7 and 8:
Foreword Drug Targeting Organ-Speci
- Page 9 and 10:
X List of Contributors Henderik W.
- Page 11 and 12:
XII List of Contributors Grietje Mo
- Page 13 and 14:
Contents Drug Targeting Organ-Speci
- Page 15 and 16:
Contents XVII 3 Pulmonary Drug Deli
- Page 17 and 18:
Contents XIX 5.2.1.6 Identification
- Page 19 and 20:
Contents XXI 7.5 In Vitro Technique
- Page 21 and 22:
Contents XXIII 9.4 Tumour Vasculatu
- Page 23 and 24:
Contents XXV 12.8. Tissue Slices fr
- Page 25 and 26:
Drug Targeting Organ-Specific Strat
- Page 27 and 28:
Dexa dexamethasone DIVEMA divinyl e
- Page 29 and 30:
LRP lung resistance related protein
- Page 31 and 32:
ROS reactive oxygen species RSV res
- Page 33 and 34:
Index a ADEPT 217, 224, 268, 291 ad
- Page 35 and 36:
e E. coli expression system 292 eff
- Page 37 and 38:
polymers, soluble 4, 218 - dendrime
- Page 39 and 40:
2 1 Drug Targeting: Basic Concepts
- Page 41 and 42:
4 1 Drug Targeting: Basic Concepts
- Page 43 and 44:
6 1 Drug Targeting: Basic Concepts
- Page 45 and 46:
8 1 Drug Targeting: Basic Concepts
- Page 47 and 48:
10 1 Drug Targeting: Basic Concepts
- Page 49 and 50:
12 1 Drug Targeting: Basic Concepts
- Page 51 and 52:
14 1 Drug Targeting: Basic Concepts
- Page 53 and 54:
16 1 Drug Targeting: Basic Concepts
- Page 55 and 56:
18 1 Drug Targeting: Basic Concepts
- Page 57 and 58:
20 1 Drug Targeting: Basic Concepts
- Page 59 and 60:
22 1 Drug Targeting: Basic Concepts
- Page 61 and 62:
24 2 Brain-Specific Drug Targeting
- Page 63 and 64:
26 2 Brain-Specific Drug Targeting
- Page 65 and 66:
28 2 Brain-Specific Drug Targeting
- Page 67 and 68:
30 2 Brain-Specific Drug Targeting
- Page 69 and 70:
32 2 Brain-Specific Drug Targeting
- Page 71 and 72:
34 2 Brain-Specific Drug Targeting
- Page 73 and 74:
36 2 Brain-Specific Drug Targeting
- Page 75 and 76:
38 2 Brain-Specific Drug Targeting
- Page 77 and 78:
40 2 Brain-Specific Drug Targeting
- Page 79 and 80:
42 2 Brain-Specific Drug Targeting
- Page 81 and 82:
44 2 Brain-Specific Drug Targeting
- Page 83 and 84:
46 2 Brain-Specific Drug Targeting
- Page 85 and 86:
48 2 Brain-Specific Drug Targeting
- Page 87 and 88:
50 2 Brain-Specific Drug Targeting
- Page 89 and 90:
52 2 Brain-Specific Drug Targeting
- Page 91 and 92:
54 3 Pulmonary Drug Delivery: Deliv
- Page 93 and 94:
56 3 Pulmonary Drug Delivery: Deliv
- Page 95 and 96:
58 3 Pulmonary Drug Delivery: Deliv
- Page 97 and 98:
60 3 Pulmonary Drug Delivery: Deliv
- Page 99 and 100:
62 3 Pulmonary Drug Delivery: Deliv
- Page 101 and 102:
64 3 Pulmonary Drug Delivery: Deliv
- Page 103 and 104:
66 3 Pulmonary Drug Delivery: Deliv
- Page 105 and 106:
68 3 Pulmonary Drug Delivery: Deliv
- Page 107 and 108:
70 3 Pulmonary Drug Delivery: Deliv
- Page 109 and 110:
72 3 Pulmonary Drug Delivery: Deliv
- Page 111 and 112:
74 3 Pulmonary Drug Delivery: Deliv
- Page 113 and 114:
76 3 Pulmonary Drug Delivery: Deliv
- Page 115 and 116:
78 3 Pulmonary Drug Delivery: Deliv
- Page 117 and 118:
80 3 Pulmonary Drug Delivery: Deliv
- Page 119 and 120:
82 3 Pulmonary Drug Delivery: Deliv
- Page 121 and 122:
84 3 Pulmonary Drug Delivery: Deliv
- Page 123 and 124:
86 3 Pulmonary Drug Delivery: Deliv
- Page 125 and 126:
4 Cell Specific Delivery of Anti-In
- Page 127 and 128:
The sinusoids are lined by the disc
- Page 129 and 130:
4.2.2.2 Phagocytosis and Transcytos
- Page 131 and 132:
ther inflammatory cells or accessor
- Page 133 and 134:
4.3 Hepatic Inflammation and Fibros
- Page 135 and 136:
process is not yet available. Sever
- Page 137 and 138:
this carrier to the KCs.When the ma
- Page 139 and 140:
e taken up rapidly by mannose recep
- Page 141 and 142:
y the transcriptional regulatory pr
- Page 143 and 144:
4.8 Testing Liver Targeting Prepara
- Page 145 and 146:
4.8 Testing Liver Targeting Prepara
- Page 147 and 148:
4.9 Targeting of Anti-inflammatory
- Page 149 and 150:
4.9 Targeting of Anti-inflammatory
- Page 151 and 152:
with monoclonal and bispecific anti
- Page 153 and 154:
References 117 [50] Coleman DL, Eur
- Page 155 and 156:
References 119 [133] Cronstein BN,
- Page 157 and 158:
5 Delivery of Drugs and Antisense O
- Page 159 and 160:
5.1 Introduction 123 convoluted tub
- Page 161 and 162:
treatment of the targeted cell and
- Page 163 and 164:
CL uptake (ml/min/g) centration pro
- Page 165 and 166:
5.2.1.4 Specific Binding of Alkylgl
- Page 167 and 168:
5.2 Renal Delivery Using Pro-Drugs
- Page 169 and 170:
5.2 Renal Delivery Using Pro-Drugs
- Page 171 and 172:
5.3 Renal Delivery Using Macromolec
- Page 173 and 174:
5.3 Renal Delivery Using Macromolec
- Page 175 and 176:
5.3 Renal Delivery Using Macromolec
- Page 177 and 178:
5.3 Renal Delivery Using Macromolec
- Page 179 and 180:
5.3 Renal Delivery Using Macromolec
- Page 181 and 182:
5.4 Renal Delivary of Antisense Oli
- Page 183 and 184:
5.4 Renal Delivery of Antisense Oli
- Page 185 and 186:
5.4.8 Benefits and Limitations of A
- Page 187 and 188:
via reabsorption from the luminal s
- Page 189 and 190:
References 153 [66] Franssen EJF, M
- Page 191 and 192:
References 155 [145] Van Zwieten PA
- Page 193 and 194:
158 6 A Practical Approach in the D
- Page 195 and 196:
160 6 A Practical Approach in the D
- Page 197 and 198:
162 6 A Practical Approach in the D
- Page 199 and 200:
164 6 A Practical Approach in the D
- Page 201 and 202:
166 6 A Practical Approach in the D
- Page 203 and 204:
168 6 A Practical Approach in the D
- Page 205 and 206:
170 6 A Practical Approach in the D
- Page 207 and 208:
172 7 Vascular Endothelium in Infla
- Page 209 and 210:
174 7 Vascular Endothelium in Infla
- Page 211 and 212:
176 7 Vascular Endothelium in Infla
- Page 213 and 214: 178 7 Vascular Endothelium in Infla
- Page 215 and 216: 180 7 Vascular Endothelium in Infla
- Page 217 and 218: 182 7 Vascular Endothelium in Infla
- Page 219 and 220: 184 7 Vascular Endothelium in Infla
- Page 221 and 222: 186 7 Vascular Endothelium in Infla
- Page 223 and 224: 188 7 Vascular Endothelium in Infla
- Page 225 and 226: 190 7 Vascular Endothelium in Infla
- Page 227 and 228: 192 7 Vascular Endothelium in Infla
- Page 229 and 230: 194 7 Vascular Endothelium in Infla
- Page 231 and 232: 196 7 Vascular Endothelium in Infla
- Page 233 and 234: 8 Strategies for Specific Drug Targ
- Page 235 and 236: 8.2.2 Histogenesis The traditional
- Page 237 and 238: may become obstructed and compresse
- Page 239 and 240: 8.5 Strategies to Deliver Drugs to
- Page 241 and 242: 8.5 Strategies to Deliver Drugs to
- Page 243 and 244: larly cytotoxic immune effector cel
- Page 245 and 246: contributes to limited tumour penet
- Page 247 and 248: ples onto anti-EGP-2 scFv. Biologic
- Page 249 and 250: In the case of drug-monoclonal anti
- Page 251 and 252: cells, the presence of co-stimulato
- Page 253 and 254: Monomethoxy-polyethylene glycol CH
- Page 255 and 256: e efficiently loaded into the lipos
- Page 257 and 258: 8.6 Clinical Studies 223 Table 8.5.
- Page 259 and 260: 8.6.3 (Synthetic) (co)Polymers Solu
- Page 261 and 262: 8.8 Conclusions and Future Perspect
- Page 263: References 229 [43] Chaouchi NA, Va
- Page 267 and 268: 234 9 Tumour Vasculature Targeting
- Page 269 and 270: 236 9 Tumour Vasculature Targeting
- Page 271 and 272: 238 9 Tumour Vasculature Targeting
- Page 273 and 274: 240 9 Tumour Vasculature Targeting
- Page 275 and 276: 242 9 Tumour Vasculature Targeting
- Page 277 and 278: 244 9 Tumour Vasculature Targeting
- Page 279 and 280: 246 9 Tumour Vasculature Targeting
- Page 281 and 282: 248 9 Tumour Vasculature Targeting
- Page 283 and 284: 250 9 Tumour Vasculature Targeting
- Page 285 and 286: 252 9 Tumour Vasculature Targeting
- Page 287 and 288: 254 9 Tumour Vasculature Targeting
- Page 289 and 290: 256 10 Phage Display Technology for
- Page 291 and 292: 258 10 Phage Display Technology for
- Page 293 and 294: 260 10 Phage Display Technology for
- Page 295 and 296: 262 10 Phage Display Technology for
- Page 297 and 298: 264 10 Phage Display Technology for
- Page 299 and 300: 266 10 Phage Display Technology for
- Page 301 and 302: 268 10 Phage Display Technology for
- Page 303 and 304: 270 10 Phage Display Technology for
- Page 305 and 306: 272 10 Phage Display Technology for
- Page 307 and 308: 11 Development of Proteinaceous Dru
- Page 309 and 310: carrier is an homogenous product. I
- Page 311 and 312: 11.3 The Homing Device 11.3 The Hom
- Page 313 and 314: malian cell lines that have acquire
- Page 315 and 316:
jugates for the delivery of other a
- Page 317 and 318:
11.5 The Linkage Between Drug and C
- Page 319 and 320:
actions are directed towards these
- Page 321 and 322:
11.5 The Linkage Between Drug and C
- Page 323 and 324:
homing potential if the antigen rec
- Page 325 and 326:
ly used promoters include T7 RNA po
- Page 327 and 328:
the baculovirus expression vector,
- Page 329 and 330:
11.8 Recombinant DNA Constructs 297
- Page 331 and 332:
11.8 Recombinant DNA Constructs 299
- Page 333 and 334:
toxic activity. Anthrax and tetanus
- Page 335 and 336:
11.9 Recombinant Domains as Buildin
- Page 337 and 338:
References 305 [16] Milstein C, Wal
- Page 339 and 340:
References 307 [99] Verma R, Boleti
- Page 341 and 342:
12 Use of Human Tissue Slices in Dr
- Page 343 and 344:
are also extensively used in a vari
- Page 345 and 346:
Meanwhile many incubation systems h
- Page 347 and 348:
12.3 Incubation and Culture of Live
- Page 349 and 350:
to investigate the effect of differ
- Page 351 and 352:
The mechanisms of uptake and excret
- Page 353 and 354:
12.6 The Use of Liver Slices in Dru
- Page 355 and 356:
12.7 Efficacy Testing of the Drug T
- Page 357 and 358:
NO x µM 80 60 40 20 * * 12.7 Effic
- Page 359 and 360:
TNFα ng/ml 1.5 1 0.5 0 * Human (n=
- Page 361 and 362:
References 329 [33] Ikejima K, Enom
- Page 363 and 364:
References 331 [109] Dutt A, Priebe
- Page 365 and 366:
334 13 Pharmacokinetic/Pharmacodyna
- Page 367 and 368:
336 13 Pharmacokinetic/Pharmacodyna
- Page 369 and 370:
338 13 Pharmacokinetic/Pharmacodyna
- Page 371 and 372:
340 13 Pharmacokinetic/Pharmacodyna
- Page 373 and 374:
342 13 Pharmacokinetic/Pharmacodyna
- Page 375 and 376:
344 13 Pharmacokinetic/Pharmacodyna
- Page 377 and 378:
346 13 Pharmacokinetic/Pharmacodyna
- Page 379 and 380:
348 13 Pharmacokinetic/Pharmacodyna
- Page 381 and 382:
350 13 Pharmacokinetic/Pharmacodyna
- Page 383 and 384:
352 13 Pharmacokinetic/Pharmacodyna
- Page 385 and 386:
354 13 Pharmacokinetic/Pharmacodyna
- Page 387 and 388:
356 13 Pharmacokinetic/Pharmacodyna
- Page 389 and 390:
358 13 Pharmacokinetic/Pharmacodyna
- Page 391 and 392:
360 13 Pharmacokinetic/Pharmacodyna
- Page 393 and 394:
362 13 Pharmacokinetic/Pharmacodyna
- Page 395 and 396:
364 13 Pharmacokinetic/Pharmacodyna
- Page 397 and 398:
366 13 Pharmacokinetic/Pharmacodyna
- Page 399 and 400:
368 13 Pharmacokinetic/Pharmacodyna
- Page 401 and 402:
370 13 Pharmacokinetic/Pharmacodyna
- Page 403 and 404:
372 14 Drug Targeting Strategy: Scr
- Page 405 and 406:
374 14 Drug Targeting Strategy: Scr