Drug Targeting Organ-Specific Strategies

e
E. coli expression system 292
effectiveness of drug targeting 141, 357,
363
endocytosis (receptor mediated) 8, 108,
191
– cytoplasmic delivery 9
– in the brain 30
– Kupffer cells 94, 108
– mitochondrial targeting 10
– nuclear targeting 9
– sinusoidal endothelial cells 92, 108
endoglin (targeting) 241, 245
endothelial cells
– activation 177
– activation inhibition 182
– angiogenic vasculature 181, 233, 265
– brain endothelium 27, 34
– inflammatory endothelial cells 172, 177,
179
– in vitro assays 34, 187, 238
– markers of 241
– sources 237
– sinusoidal endothelial cells 91, 93, 100
– pulmonary endothelial cells 17, 181
– tumor vasculature 17, 233, 241, 249, 265,
266
expression systems 292, 296
f
fibrosis
– kidney 150
– liver 96, 98
folate
– as homing device 281
– pro-drug approach 134
formulations for pulmonary delivery 67
fungal expression system 293
g
galactose receptors 91, 94, 114
gene therapy 9, 16, 221
– brain targeting 48
– nuclear targeting 9
– pharmacokinetic considerations 362
– pulmonary delivery/targeting 54, 81
glomerulonephritis 150
γ-glutamyl pro-drug approach 133
h
HDL, see lipoproteins
hepatic stellate cells 95
hepatocytes 91, 309, 318, 365
HIV, drug targeting to 46, 282, 301, 365
HIV, infection 25, 373
homing device 279
HPMA, see polymers, soluble 5
human tissue slices, see tissue slices
i
immunogenicity of drug targeting therapies
18, 210, 222, 268
immunoliposomes, see liposomes
immune response 16, 25, 160, 171
immunotherapy of cancer 209, 216, 224,
226, 227
immunotoxins 213, 223, 245, 246, 298,
300
inflammation 171
– and angiogenesis 175, 186, 234
– apoptosis in, see apoptosis
– in brain diseases 25
– inflammatory bowel disease 159, 174
– rheumatoid arthritis 173, 177
– kidney 124, 148
– liver 89, 93, 94, 96, 323
– role of NFκB 97, 105, 174, 178
– atherosclerosis 174, 177
inflammatory bowel disease (IBD), see also
inflammation 174, 177
– animal models, see animal models
(of disease)
– bowel pH 162
– colonic delivery 160
inhalation therapy 53
– dry powder inhalation 73
– formulations for 67
inhaler
– dry powder inhaler 63, 65
– nebulizer 63, 64
– (pressurized) metered dose inhaler 63,
65
insulin receptor targeting 30, 42
integrin targeting 181, 246
integrins, see also angiogenesis 180, 236
internalization, see endocytosis
intestines, see colon
intracelluar routing, see endocytosis
k
kidney 121
– animal models, see animal models
(of disease)
– cells of the 123
– diseases of the 124
– drug targeting to 124, 135
– in vitro models 149
– tissue slices 327
– renal catabolism of LMWP 139
Krumdieck slicer 310, 312
Kupffer cells 93, 100
l
LDL, see lipoproteins
leukaemia 200, 222
linkage between drug and carrier, see conjugation
techniques
Index 379