Drug Targeting Organ-Specific Strategies

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XXX Abbreviations and Acronyms GSH glutathione γ-GTP γ-glutamyl transpeptidase HAMA human anti-mouse antibody HDL high-density lipoprotein HDMEC human dermal microvascular endothelial cell HFA hydrofluoroalkane HGF hepatocyte growth factor HIV human immunodeficiency virus HPMA N(-2-hydroxypropyl)methacrylamide HRP horseradish peroxidase HSA human serum albumin HSC hepatic stellate cell HUVEC human umbilical vein endothelial cell IBD inflammatory bowel disease ICAM intercellular adhesion molecule i.c.v. intracerebroventricular IFN interferon IGFII/M6P insulin-like growth factor II/mannose-6-phosphate receptor IgG immunoglobulin IgSF immunoglobulin superfamily IκB inhibitory factor κB IKK IκB-kinase IL interleukin IP-10 interferon γ-inducible protein 10 IPTG isopropyl-β-D-thiogalactopyranoside IT immunotoxin JAB JAK binding protein JAK janus kinase KC Kupffer cell km Michaelis-Menten constant of transport LACHSA lactosylated HSA LAK lymphokine activated killer cells LAT large neutral amino acid transporter LDH lactate dehydrogenase (ox)LDL (oxidized) low-density lipoprotein LF lethal factor LH-RH luteinizing hormone releasing hormone LMWP low molecular weight protein LPS lipopolysaccharide LU lucigenin
LRP lung resistance related protein LT leukotriene LZM lysozyme mAb/MAb monoclonal antibody MACS magnetic activated cell sorting Mal maleylated (Chapter 4); maleic acid (Chapter 11) Man mannosylated (Chapter 4); mannose (Chapter 5) MARCO macrophage receptor with collagenous structure MBP maltose binding protein MCP(-1) monocyte chemotactic protein(-1) (p)MDI (pressurized) metered dose inhaler MDR multi-drug resistance MHC major histocompatibility complex MIP maximal inspiratory pressure (Chapter 3); macrophage inflammatory protein (–1α/β) MLV-MTP-PE multilamellar vesicles-muramyl tripeptide-phosphatidylethanolamine MMAD mass median aerodynamic diameter MMP matrix metalloproteinase MPEG monomethoxypolyethyleneglycol MPTP 1-methyl-4-phenylpyridinium MRP multi-drug resistance related protein MSLI multi stage liquid impinger MTT 3[4,5-dimethyl-thiazole-2-yl]-2,5-diphenyltetrazolium bromide MUC-1 mucin 1 Nap naproxen Na/Pi-2 co-transporter sodium/phosphate co-transporter NBD 4-nitrobenz-2-oxa-1,3-diazole NCE new chemical entity NCS neocarzinostatin NFκB nuclear factor κB NGF nerve growth factor NHL non-Hodgkin’s lymphoma NIK NFκB-inducible kinase NK natural killer cell NLA neutral avidin NLS nuclear localization sequence NO nitric oxide NOx nitrite and nitrate iNOS inducible NO synthase NSAID non steroidal anti-inflammatory drug ODN oligodeoxynucleotide Abbreviations and Acronyms XXXI
Page 1 and 2: Drug Targeting Organ-Specific Strat
Page 5 and 6: Preface Drug Targeting Organ-Specif
Page 7 and 8: Foreword Drug Targeting Organ-Speci
Page 9 and 10: X List of Contributors Henderik W.
Page 11 and 12: XII List of Contributors Grietje Mo
Page 13 and 14: Contents Drug Targeting Organ-Speci
Page 15 and 16: Contents XVII 3 Pulmonary Drug Deli
Page 17 and 18: Contents XIX 5.2.1.6 Identification
Page 19 and 20: Contents XXI 7.5 In Vitro Technique
Page 21 and 22: Contents XXIII 9.4 Tumour Vasculatu
Page 23 and 24: Contents XXV 12.8. Tissue Slices fr
Page 27: Dexa dexamethasone DIVEMA divinyl e
Page 31 and 32: ROS reactive oxygen species RSV res
Page 33 and 34: Index a ADEPT 217, 224, 268, 291 ad
Page 35 and 36: e E. coli expression system 292 eff
Page 37 and 38: polymers, soluble 4, 218 - dendrime
Page 39 and 40: 2 1 Drug Targeting: Basic Concepts
Page 61 and 62: 24 2 Brain-Specific Drug Targeting
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42 2 Brain-Specific Drug Targeting
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54 3 Pulmonary Drug Delivery: Deliv
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4 Cell Specific Delivery of Anti-In
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The sinusoids are lined by the disc
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4.2.2.2 Phagocytosis and Transcytos
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ther inflammatory cells or accessor
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4.3 Hepatic Inflammation and Fibros
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process is not yet available. Sever
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this carrier to the KCs.When the ma
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e taken up rapidly by mannose recep
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y the transcriptional regulatory pr
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4.8 Testing Liver Targeting Prepara
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4.8 Testing Liver Targeting Prepara
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4.9 Targeting of Anti-inflammatory
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4.9 Targeting of Anti-inflammatory
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with monoclonal and bispecific anti
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References 117 [50] Coleman DL, Eur
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References 119 [133] Cronstein BN,
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5 Delivery of Drugs and Antisense O
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5.1 Introduction 123 convoluted tub
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treatment of the targeted cell and
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CL uptake (ml/min/g) centration pro
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5.2.1.4 Specific Binding of Alkylgl
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5.2 Renal Delivery Using Pro-Drugs
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5.2 Renal Delivery Using Pro-Drugs
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5.3 Renal Delivery Using Macromolec
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5.4 Renal Delivary of Antisense Oli
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5.4 Renal Delivery of Antisense Oli
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5.4.8 Benefits and Limitations of A
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via reabsorption from the luminal s
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References 153 [66] Franssen EJF, M
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References 155 [145] Van Zwieten PA
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158 6 A Practical Approach in the D
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172 7 Vascular Endothelium in Infla
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8 Strategies for Specific Drug Targ
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8.2.2 Histogenesis The traditional
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may become obstructed and compresse
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8.5 Strategies to Deliver Drugs to
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8.5 Strategies to Deliver Drugs to
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larly cytotoxic immune effector cel
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contributes to limited tumour penet
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ples onto anti-EGP-2 scFv. Biologic
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In the case of drug-monoclonal anti
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cells, the presence of co-stimulato
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Monomethoxy-polyethylene glycol CH
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e efficiently loaded into the lipos
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8.6 Clinical Studies 223 Table 8.5.
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8.6.3 (Synthetic) (co)Polymers Solu
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8.8 Conclusions and Future Perspect
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References 229 [43] Chaouchi NA, Va
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References 231 [126] Czuczman MS, G
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234 9 Tumour Vasculature Targeting
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256 10 Phage Display Technology for
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11 Development of Proteinaceous Dru
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carrier is an homogenous product. I
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11.3 The Homing Device 11.3 The Hom
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malian cell lines that have acquire
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jugates for the delivery of other a
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11.5 The Linkage Between Drug and C
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actions are directed towards these
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11.5 The Linkage Between Drug and C
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homing potential if the antigen rec
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ly used promoters include T7 RNA po
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the baculovirus expression vector,
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11.8 Recombinant DNA Constructs 297
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11.8 Recombinant DNA Constructs 299
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toxic activity. Anthrax and tetanus
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11.9 Recombinant Domains as Buildin
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References 305 [16] Milstein C, Wal
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References 307 [99] Verma R, Boleti
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12 Use of Human Tissue Slices in Dr
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are also extensively used in a vari
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Meanwhile many incubation systems h
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12.3 Incubation and Culture of Live
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to investigate the effect of differ
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The mechanisms of uptake and excret
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12.6 The Use of Liver Slices in Dru
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12.7 Efficacy Testing of the Drug T
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NO x µM 80 60 40 20 * * 12.7 Effic
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TNFα ng/ml 1.5 1 0.5 0 * Human (n=
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References 329 [33] Ikejima K, Enom
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References 331 [109] Dutt A, Priebe
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334 13 Pharmacokinetic/Pharmacodyna
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372 14 Drug Targeting Strategy: Scr
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374 14 Drug Targeting Strategy: Scr
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Drug Targeting Organ-Specific Strategies

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