Drug Targeting Organ-Specific Strategies

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List of Contributors Jan-Willem Arends Maastricht University Department of Pathology PO Box 616 6200 MD Maastricht the Netherlands Sigridur A. Ásgeirsdóttir Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery Ant. Deusinglaan 1 9713 AV Groningen the Netherlands s.asgeirsdottir@farm.rug.nl Leonie Beljaars Drug Targeting Organ-Specific Strategies. Edited by G. Molema, D. K. F. Meijer Copyright © 2001 Wiley-VCH Verlag GmbH ISBNs: 3-527-29989-0 (Hardcover); 3-527-60006-X (Electronic) Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery Ant. Deusinglaan 1 9713 AV Groningen the Netherlands l.beljaars@farm.rug.nl Ulrich Bickel Texas Tech University HSC School of Pharmacy Pharmaceutical Sciences 1300 S Coulter Amarillo, Texas 79106 USA ubickel@ama.ttuhsc.edu Anne H. de Boer Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmaceutical Technology and Biopharmacy Ant. Deusinglaan 1 9713 AV Groningen the Netherlands a.h.de.boer@farm.rug.nl Maaike Everts Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery Ant. Deusinglaan 1 9713 AV Groningen the Netherlands m.everts@farm.rug.nl
X List of Contributors Henderik W. Frijlink Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmaceutical Technology and Biopharmacy Ant. Deusinglaan 1 9713 AV Groningen the Netherlands h.w.frijlink@farm.rug.nl Arjan W. Griffioen Maastricht University/ University Hospital Maastricht Department of Internal Medicine Tumor Angiogenesis Laboratory Peter Debyelaan 25 6202 AZ Maastricht the Netherlands a.griffioen@intmed.unimaas.nl Geny M. M. Groothuis Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery Ant. Deusinglaan 1 9713 AV Groningen the Netherlands G.M.M.Groothuis@farm.rug.nl Marijke Haas Groningen University Institute for Drug Exploration (GUIDE) Department of Clinical Pharmacology Ant. Deusinglaan 1 9713 AV Groningen the Netherlands m.haas@med.rug.nl R. Folgert G. Haverdings Groningen University Institute for Drug Exploration (GUIDE) Department of Pharmacokinetics and Drug Delivery Ant. Deusinglaan 1 9713 AV Groningen the Netherlands r.f.g.haverdings@farm.rug.nl Wijnand Helfrich Groningen University Institute for Drug Exploration (GUIDE) Department of Pathology and Laboratory Medicine Medical Biology Section Tumor Immunology Laboratory Hanzeplein 1 9713 GZ Groningen the Netherlands w.helfrich@med.rug.nl Hennie R. Hoogenboom Dyax bv PO Box 5800 6202 AZ Maastricht the Netherlands hhoogenboom@dyax.com Jörg Huwyler F. Hoffmann-LaRoche Ltd. CNS Research PRBN, Bldg. 68/323a CH-4070 Basel Switzerland joerg.huwyler@roche.com
Page 1 and 2: Drug Targeting Organ-Specific Strat
Page 5 and 6: Preface Drug Targeting Organ-Specif
Page 7: Foreword Drug Targeting Organ-Speci
Page 11 and 12: XII List of Contributors Grietje Mo
Page 13 and 14: Contents Drug Targeting Organ-Speci
Page 15 and 16: Contents XVII 3 Pulmonary Drug Deli
Page 17 and 18: Contents XIX 5.2.1.6 Identification
Page 19 and 20: Contents XXI 7.5 In Vitro Technique
Page 21 and 22: Contents XXIII 9.4 Tumour Vasculatu
Page 23 and 24: Contents XXV 12.8. Tissue Slices fr
Page 27 and 28: Dexa dexamethasone DIVEMA divinyl e
Page 29 and 30: LRP lung resistance related protein
Page 31 and 32: ROS reactive oxygen species RSV res
Page 33 and 34: Index a ADEPT 217, 224, 268, 291 ad
Page 35 and 36: e E. coli expression system 292 eff
Page 37 and 38: polymers, soluble 4, 218 - dendrime
Page 39 and 40: 2 1 Drug Targeting: Basic Concepts
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22 1 Drug Targeting: Basic Concepts
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24 2 Brain-Specific Drug Targeting
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54 3 Pulmonary Drug Delivery: Deliv
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4 Cell Specific Delivery of Anti-In
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The sinusoids are lined by the disc
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4.2.2.2 Phagocytosis and Transcytos
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ther inflammatory cells or accessor
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4.3 Hepatic Inflammation and Fibros
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process is not yet available. Sever
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this carrier to the KCs.When the ma
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e taken up rapidly by mannose recep
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y the transcriptional regulatory pr
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4.8 Testing Liver Targeting Prepara
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4.8 Testing Liver Targeting Prepara
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4.9 Targeting of Anti-inflammatory
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4.9 Targeting of Anti-inflammatory
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with monoclonal and bispecific anti
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References 117 [50] Coleman DL, Eur
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References 119 [133] Cronstein BN,
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5 Delivery of Drugs and Antisense O
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5.1 Introduction 123 convoluted tub
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treatment of the targeted cell and
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CL uptake (ml/min/g) centration pro
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5.2.1.4 Specific Binding of Alkylgl
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5.2 Renal Delivery Using Pro-Drugs
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5.2 Renal Delivery Using Pro-Drugs
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5.3 Renal Delivery Using Macromolec
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5.4 Renal Delivary of Antisense Oli
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5.4 Renal Delivery of Antisense Oli
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5.4.8 Benefits and Limitations of A
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via reabsorption from the luminal s
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References 153 [66] Franssen EJF, M
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References 155 [145] Van Zwieten PA
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158 6 A Practical Approach in the D
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172 7 Vascular Endothelium in Infla
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8 Strategies for Specific Drug Targ
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8.2.2 Histogenesis The traditional
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may become obstructed and compresse
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8.5 Strategies to Deliver Drugs to
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8.5 Strategies to Deliver Drugs to
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larly cytotoxic immune effector cel
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contributes to limited tumour penet
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ples onto anti-EGP-2 scFv. Biologic
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In the case of drug-monoclonal anti
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cells, the presence of co-stimulato
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Monomethoxy-polyethylene glycol CH
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e efficiently loaded into the lipos
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8.6 Clinical Studies 223 Table 8.5.
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8.6.3 (Synthetic) (co)Polymers Solu
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8.8 Conclusions and Future Perspect
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References 229 [43] Chaouchi NA, Va
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References 231 [126] Czuczman MS, G
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234 9 Tumour Vasculature Targeting
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256 10 Phage Display Technology for
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11 Development of Proteinaceous Dru
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carrier is an homogenous product. I
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11.3 The Homing Device 11.3 The Hom
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malian cell lines that have acquire
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jugates for the delivery of other a
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11.5 The Linkage Between Drug and C
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actions are directed towards these
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11.5 The Linkage Between Drug and C
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homing potential if the antigen rec
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ly used promoters include T7 RNA po
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the baculovirus expression vector,
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11.8 Recombinant DNA Constructs 297
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11.8 Recombinant DNA Constructs 299
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toxic activity. Anthrax and tetanus
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11.9 Recombinant Domains as Buildin
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References 305 [16] Milstein C, Wal
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References 307 [99] Verma R, Boleti
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12 Use of Human Tissue Slices in Dr
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are also extensively used in a vari
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Meanwhile many incubation systems h
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12.3 Incubation and Culture of Live
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to investigate the effect of differ
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The mechanisms of uptake and excret
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12.6 The Use of Liver Slices in Dru
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12.7 Efficacy Testing of the Drug T
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NO x µM 80 60 40 20 * * 12.7 Effic
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TNFα ng/ml 1.5 1 0.5 0 * Human (n=
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References 329 [33] Ikejima K, Enom
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References 331 [109] Dutt A, Priebe
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334 13 Pharmacokinetic/Pharmacodyna
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372 14 Drug Targeting Strategy: Scr
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374 14 Drug Targeting Strategy: Scr
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Drug Targeting Organ-Specific Strategies

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