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Drug Targeting Organ-Specific Strat
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Drug Targeting Organ-Specific Strat
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Preface Drug Targeting Organ-Specif
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Foreword Drug Targeting Organ-Speci
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X List of Contributors Henderik W.
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XII List of Contributors Grietje Mo
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Contents Drug Targeting Organ-Speci
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Contents XVII 3 Pulmonary Drug Deli
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Contents XIX 5.2.1.6 Identification
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Contents XXI 7.5 In Vitro Technique
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Contents XXIII 9.4 Tumour Vasculatu
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Contents XXV 12.8. Tissue Slices fr
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Drug Targeting Organ-Specific Strat
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Dexa dexamethasone DIVEMA divinyl e
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LRP lung resistance related protein
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ROS reactive oxygen species RSV res
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Index a ADEPT 217, 224, 268, 291 ad
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e E. coli expression system 292 eff
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polymers, soluble 4, 218 - dendrime
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2 1 Drug Targeting: Basic Concepts
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4 1 Drug Targeting: Basic Concepts
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6 1 Drug Targeting: Basic Concepts
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22 1 Drug Targeting: Basic Concepts
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24 2 Brain-Specific Drug Targeting
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26 2 Brain-Specific Drug Targeting
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28 2 Brain-Specific Drug Targeting
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30 2 Brain-Specific Drug Targeting
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32 2 Brain-Specific Drug Targeting
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34 2 Brain-Specific Drug Targeting
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36 2 Brain-Specific Drug Targeting
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38 2 Brain-Specific Drug Targeting
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40 2 Brain-Specific Drug Targeting
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42 2 Brain-Specific Drug Targeting
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44 2 Brain-Specific Drug Targeting
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46 2 Brain-Specific Drug Targeting
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48 2 Brain-Specific Drug Targeting
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50 2 Brain-Specific Drug Targeting
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52 2 Brain-Specific Drug Targeting
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54 3 Pulmonary Drug Delivery: Deliv
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56 3 Pulmonary Drug Delivery: Deliv
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58 3 Pulmonary Drug Delivery: Deliv
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60 3 Pulmonary Drug Delivery: Deliv
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82 3 Pulmonary Drug Delivery: Deliv
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84 3 Pulmonary Drug Delivery: Deliv
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86 3 Pulmonary Drug Delivery: Deliv
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4 Cell Specific Delivery of Anti-In
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The sinusoids are lined by the disc
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4.2.2.2 Phagocytosis and Transcytos
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ther inflammatory cells or accessor
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4.3 Hepatic Inflammation and Fibros
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process is not yet available. Sever
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this carrier to the KCs.When the ma
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e taken up rapidly by mannose recep
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y the transcriptional regulatory pr
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4.8 Testing Liver Targeting Prepara
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4.8 Testing Liver Targeting Prepara
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4.9 Targeting of Anti-inflammatory
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4.9 Targeting of Anti-inflammatory
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with monoclonal and bispecific anti
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References 117 [50] Coleman DL, Eur
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References 119 [133] Cronstein BN,
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5 Delivery of Drugs and Antisense O
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5.1 Introduction 123 convoluted tub
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treatment of the targeted cell and
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CL uptake (ml/min/g) centration pro
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5.2.1.4 Specific Binding of Alkylgl
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5.2 Renal Delivery Using Pro-Drugs
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5.2 Renal Delivery Using Pro-Drugs
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5.3 Renal Delivery Using Macromolec
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5.3 Renal Delivery Using Macromolec
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5.3 Renal Delivery Using Macromolec
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5.3 Renal Delivery Using Macromolec
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5.3 Renal Delivery Using Macromolec
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5.4 Renal Delivary of Antisense Oli
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5.4 Renal Delivery of Antisense Oli
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5.4.8 Benefits and Limitations of A
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via reabsorption from the luminal s
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References 153 [66] Franssen EJF, M
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References 155 [145] Van Zwieten PA
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158 6 A Practical Approach in the D
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160 6 A Practical Approach in the D
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162 6 A Practical Approach in the D
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164 6 A Practical Approach in the D
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166 6 A Practical Approach in the D
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168 6 A Practical Approach in the D
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170 6 A Practical Approach in the D
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172 7 Vascular Endothelium in Infla
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174 7 Vascular Endothelium in Infla
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176 7 Vascular Endothelium in Infla
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178 7 Vascular Endothelium in Infla
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180 7 Vascular Endothelium in Infla
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182 7 Vascular Endothelium in Infla
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184 7 Vascular Endothelium in Infla
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186 7 Vascular Endothelium in Infla
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188 7 Vascular Endothelium in Infla
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190 7 Vascular Endothelium in Infla
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192 7 Vascular Endothelium in Infla
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194 7 Vascular Endothelium in Infla
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196 7 Vascular Endothelium in Infla
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8 Strategies for Specific Drug Targ
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8.2.2 Histogenesis The traditional
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may become obstructed and compresse
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8.5 Strategies to Deliver Drugs to
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8.5 Strategies to Deliver Drugs to
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larly cytotoxic immune effector cel
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contributes to limited tumour penet
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ples onto anti-EGP-2 scFv. Biologic
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In the case of drug-monoclonal anti
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cells, the presence of co-stimulato
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Monomethoxy-polyethylene glycol CH
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e efficiently loaded into the lipos
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8.6 Clinical Studies 223 Table 8.5.
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8.6.3 (Synthetic) (co)Polymers Solu
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8.8 Conclusions and Future Perspect
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References 229 [43] Chaouchi NA, Va
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References 231 [126] Czuczman MS, G
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234 9 Tumour Vasculature Targeting
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236 9 Tumour Vasculature Targeting
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238 9 Tumour Vasculature Targeting
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240 9 Tumour Vasculature Targeting
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242 9 Tumour Vasculature Targeting
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244 9 Tumour Vasculature Targeting
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246 9 Tumour Vasculature Targeting
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248 9 Tumour Vasculature Targeting
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250 9 Tumour Vasculature Targeting
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252 9 Tumour Vasculature Targeting
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368 13 Pharmacokinetic/Pharmacodyna
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370 13 Pharmacokinetic/Pharmacodyna
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372 14 Drug Targeting Strategy: Scr
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374 14 Drug Targeting Strategy: Scr