Drug Targeting Organ-Specific Strategies

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XXXIV Abbreviations and Acronyms Vmax VT VCAM maximum transport (between compartments) tidal volume vascular cell adhesion molecule VEGF(R) vascular endothelial growth factor (receptor) VH heavy chain variable domain VIP vasoactive intestinal polypeptide VL light chain variable domain VMAD volume median aerodynamic diameter χ dynamic shape factor Φ flow rate (air) ΦV volumetric flow rate (of air) ρA density of air ρP particle density ∆P pressure difference
Index a ADEPT 217, 224, 268, 291 adhesion molecules 93, 97, 172, 248 adhesion molecule targeting 81, 181, 182, 191, 248, 249 airways 55, 58 albumin, see proteins, modified (plasma) alkylglycoside targeting 126, 131 alveoli 55, 58 Alzheimer disease 23 amino acid pro-drug approach 132 angiogenesis 234 – and inflammation 175, 186, 234 – assays, in vitro 239 – assays, in vivo 240 – integrins, role of 236 – VEGF, role of 235 animal models (of disease) – angiogenesis 190, 240 – atherosclerosis 190 – brain diseases 45 – brain uptake studies 31 – colonic delivery 160 – inflammation 189, 190 – inflammatory bowel disease 160, 189 – liver targeting 106, 109 – renal targeting 150 – rheumatoid arthritis 189 – tumor vasculature targeting 247, 248, 250 – tumor targeting 226 antibodies, (monoclonal) 3, 205, 207, 256, 278, 297 – affinity maturation 266 – bispecific 207, 215, 224, 247 – brain targeting 41 – clinical applications 11, 15, 221, 268 – diabodies 207, 267 – drug conjugates 213 – effector mechanisms 209 – endothelial cell targeting 17, 180, 246, 247, 249 – engineering 296 – engineering in phage display 267 – human(ized) antibodies 207, 211, 212, 222, 261, 268 Drug Targeting Organ-Specific Strategies. Edited by G. Molema, D. K. F. Meijer Copyright © 2001 Wiley-VCH Verlag GmbH ISBNs: 3-527-29989-0 (Hardcover); 3-527-60006-X (Electronic) – immunocytokines 299 – immunoliposomes, see liposomes – immunotoxins, see immunotoxins – phage display 256 – pharmacokinetic modelling 364 – radioimmunoconjugates 181, 215, 246, 249, 364 – scFv 211, 260, 297 – tumor (endothelial) cell targeting 205, 209, 246, 247, 249, 268 antisense oligodeoxynucleotides – brain targeting 46 – cellular handling 147 – pharmacologic activity 145, 185 – pharmacokinetics 146, 362 – renal targeting 144, 148 – stabilization 145 apoptosis – in inflammation 173 – in antibody therapy 210 aprotinine 140 arginine vasopressin targeting 126 asialoglycoprotein receptors 91 assembly domains 303 asthma 53, 77, 175 atherosclerosis, see inflammation avidin-biotin linker technology 43 b baculovirus expression system 294 biodegradable linkers 287 blood-brain barrier 23, 26 blood-cerebrospinal fluid barrier 26 blood coagulation, targeted induction of 247 brain 23 – brain uptake index 31 – architecture 26 – CNS diseases 23pp – drug targeting to 34pp – pharmacologic drug delivery strategies 40 – physical drug delivery strategies 36 – in vitro models 34 – in vivo models 31 – receptor mediated uptake systems 29 – transport systems 28
Page 1 and 2: Drug Targeting Organ-Specific Strat
Page 5 and 6: Preface Drug Targeting Organ-Specif
Page 7 and 8: Foreword Drug Targeting Organ-Speci
Page 9 and 10: X List of Contributors Henderik W.
Page 11 and 12: XII List of Contributors Grietje Mo
Page 13 and 14: Contents Drug Targeting Organ-Speci
Page 15 and 16: Contents XVII 3 Pulmonary Drug Deli
Page 17 and 18: Contents XIX 5.2.1.6 Identification
Page 19 and 20: Contents XXI 7.5 In Vitro Technique
Page 21 and 22: Contents XXIII 9.4 Tumour Vasculatu
Page 23 and 24: Contents XXV 12.8. Tissue Slices fr
Page 27 and 28: Dexa dexamethasone DIVEMA divinyl e
Page 29 and 30: LRP lung resistance related protein
Page 31: ROS reactive oxygen species RSV res
Page 35 and 36: e E. coli expression system 292 eff
Page 37 and 38: polymers, soluble 4, 218 - dendrime
Page 39 and 40: 2 1 Drug Targeting: Basic Concepts
Page 61 and 62: 24 2 Brain-Specific Drug Targeting
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46 2 Brain-Specific Drug Targeting
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54 3 Pulmonary Drug Delivery: Deliv
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4 Cell Specific Delivery of Anti-In
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The sinusoids are lined by the disc
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4.2.2.2 Phagocytosis and Transcytos
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ther inflammatory cells or accessor
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4.3 Hepatic Inflammation and Fibros
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process is not yet available. Sever
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this carrier to the KCs.When the ma
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e taken up rapidly by mannose recep
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y the transcriptional regulatory pr
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4.8 Testing Liver Targeting Prepara
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4.8 Testing Liver Targeting Prepara
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4.9 Targeting of Anti-inflammatory
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4.9 Targeting of Anti-inflammatory
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with monoclonal and bispecific anti
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References 117 [50] Coleman DL, Eur
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References 119 [133] Cronstein BN,
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5 Delivery of Drugs and Antisense O
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5.1 Introduction 123 convoluted tub
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treatment of the targeted cell and
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CL uptake (ml/min/g) centration pro
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5.2.1.4 Specific Binding of Alkylgl
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5.2 Renal Delivery Using Pro-Drugs
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5.2 Renal Delivery Using Pro-Drugs
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5.3 Renal Delivery Using Macromolec
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5.4 Renal Delivary of Antisense Oli
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5.4 Renal Delivery of Antisense Oli
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5.4.8 Benefits and Limitations of A
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via reabsorption from the luminal s
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References 153 [66] Franssen EJF, M
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References 155 [145] Van Zwieten PA
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158 6 A Practical Approach in the D
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172 7 Vascular Endothelium in Infla
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8 Strategies for Specific Drug Targ
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8.2.2 Histogenesis The traditional
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may become obstructed and compresse
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8.5 Strategies to Deliver Drugs to
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8.5 Strategies to Deliver Drugs to
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larly cytotoxic immune effector cel
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contributes to limited tumour penet
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ples onto anti-EGP-2 scFv. Biologic
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In the case of drug-monoclonal anti
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cells, the presence of co-stimulato
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Monomethoxy-polyethylene glycol CH
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e efficiently loaded into the lipos
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8.6 Clinical Studies 223 Table 8.5.
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8.6.3 (Synthetic) (co)Polymers Solu
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8.8 Conclusions and Future Perspect
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References 229 [43] Chaouchi NA, Va
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References 231 [126] Czuczman MS, G
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234 9 Tumour Vasculature Targeting
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256 10 Phage Display Technology for
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11 Development of Proteinaceous Dru
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carrier is an homogenous product. I
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11.3 The Homing Device 11.3 The Hom
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malian cell lines that have acquire
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jugates for the delivery of other a
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11.5 The Linkage Between Drug and C
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actions are directed towards these
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11.5 The Linkage Between Drug and C
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homing potential if the antigen rec
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ly used promoters include T7 RNA po
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the baculovirus expression vector,
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11.8 Recombinant DNA Constructs 297
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11.8 Recombinant DNA Constructs 299
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toxic activity. Anthrax and tetanus
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11.9 Recombinant Domains as Buildin
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References 305 [16] Milstein C, Wal
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References 307 [99] Verma R, Boleti
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12 Use of Human Tissue Slices in Dr
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are also extensively used in a vari
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Meanwhile many incubation systems h
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12.3 Incubation and Culture of Live
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to investigate the effect of differ
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The mechanisms of uptake and excret
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12.6 The Use of Liver Slices in Dru
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12.7 Efficacy Testing of the Drug T
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NO x µM 80 60 40 20 * * 12.7 Effic
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TNFα ng/ml 1.5 1 0.5 0 * Human (n=
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References 329 [33] Ikejima K, Enom
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References 331 [109] Dutt A, Priebe
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334 13 Pharmacokinetic/Pharmacodyna
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372 14 Drug Targeting Strategy: Scr
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374 14 Drug Targeting Strategy: Scr
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