Drug Targeting Organ-Specific Strategies

328 12 Use of Human Tissue Slices in Drug Targeting Research
specificity of carrier-mediated uptake of drugs. In addition, the distribution of the drug into
different cell types in the tissue can easily be studied in preparations of organ slices, as can
the efficacy of the drug which is coupled to the targeting device. Furthermore, metabolism
and toxicity of the drug targeting device or the released drug can be determined in the human
liver. And finally, an important aspect of this type of in vitro research in man is, that it
will ultimately lead to a reduction in the use of animal experiments.
In future, drug targeting devices aimed at other human organs may also be studied using
precision-cut tissue slices.The latest data/literature on precision-cut tissue slices can be found
at http://www.farm.rug.nl/slice/open.html.
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