Drug Targeting Organ-Specific Strategies

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XXVIII Abbreviations and Acronyms Bs(M)Ab bispecific (monoclonal) antibody BUI brain uptake index C proportionality constant (Chapter 3); complement (Chapter 8); (drug) carrier, any part of a drug-carrier conjugate which is not the pharmacologically active moiety (Chapter 13) Cp plasma concentration Css drug concentration at steady state CT tissue concentration CAM chick chorio-allantoic membrane assay CAT catalase; chloramphenicol acetyl transferase (Chapter 3) CBF cerebral blood flow CCA cell cycle arrest CD cluster of differentiation CDR complementary determining region CEA carcinoembryonic antigen CFC chlorofluorocarbon cfu colony-forming units CHO Chinese hamster ovary cells CL clearance CLuptake,app apparent clearance uptake CLuptake clearance uptake CLL chronic lymphoblastic leukaemia CMV cytomegalovirus CNS central nervous system COER controlled onset extended release COPD chronic obstructive pulmonary disease COS African green monkey kidney cells COX cyclooxygenase CPG2 pseudomonas carboxypeptidase-2 CSF cerebrospinal fluid CTDC colon-targeted delivery capsule CTL cytotoxic T lymphocyte CTLA-4 cytotoxic T lymphocyte associated protein-4 CVO circumventricular organ D (active, free) drug, active form of the drug, not bound to drug carrier DA aerodynamic particle diameter DE equivalent volume diameter DAB diphtheria toxin enzymatic A domain and binding B domain DC dendritic cell (Chapter 1); drug-carrier conjugate, the conjugate of a drug and a drug carrier (Chapter 13) DDI drug delivery index
Dexa dexamethasone DIVEMA divinyl ether and maleic anhydride copolymer DOC system dynamic organ culture system DPI dry powder inhaler DSS dextran sodium sulphate DT diphtheria toxin DTH delayed-type hypersensitivity DTI drug targeting index DTPA diethylenetriaminepenta acid EC energy charge ECM extracellular matrix EF edema factor EF-2 elongation factor-2 EGF epidermal growth factor EGP-2 epithelial glycoprotein-2 ELISA enzyme-linked immunosorbent assay EMSA electric mobility shift assay EPOR erythropoietin receptor f p Fab’ plasma unbound fraction antibody fragment with antigen binding capacity F(ab’) 2 antibody fragment consisting of two Fab’ FACS fluorescent activated cell sorting FBP folate-binding protein FEV1 forced expiratory volume in 1 s (a/b)FGF (acidic/basic)fibroblast growth factor (is FGF-1/-2) FIR flow increase rate Form formaldehyde-treated FPF fine particle fraction Fu(A) function of the cross section of a flow constriction Gal galactose GDNF glial cell-line derived neurotrophic factor GFP green fluorescent protein GFR glomerular filtration rate GGT γ-glutamyl transpeptidase GI gastrointestinal Glc glucose Gludopa γ-glutamyl pro-drug of l-dopa GOX glucose oxidase gp glycoprotein GR glucocorticoid receptor GRE glucocorticoid responsive element GRO growth related protein Abbreviations and Acronyms XXIX
Page 1 and 2: Drug Targeting Organ-Specific Strat
Page 3 and 4: Drug Targeting Organ-Specific Strat
Page 5 and 6: Preface Drug Targeting Organ-Specif
Page 7 and 8: Foreword Drug Targeting Organ-Speci
Page 9 and 10: X List of Contributors Henderik W.
Page 11 and 12: XII List of Contributors Grietje Mo
Page 13 and 14: Contents Drug Targeting Organ-Speci
Page 15 and 16: Contents XVII 3 Pulmonary Drug Deli
Page 17 and 18: Contents XIX 5.2.1.6 Identification
Page 19 and 20: Contents XXI 7.5 In Vitro Technique
Page 21 and 22: Contents XXIII 9.4 Tumour Vasculatu
Page 23 and 24: Contents XXV 12.8. Tissue Slices fr
Page 25: Drug Targeting Organ-Specific Strat
Page 29 and 30: LRP lung resistance related protein
Page 31 and 32: ROS reactive oxygen species RSV res
Page 33 and 34: Index a ADEPT 217, 224, 268, 291 ad
Page 35 and 36: e E. coli expression system 292 eff
Page 37 and 38: polymers, soluble 4, 218 - dendrime
Page 39 and 40: 2 1 Drug Targeting: Basic Concepts
Page 61 and 62: 24 2 Brain-Specific Drug Targeting
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40 2 Brain-Specific Drug Targeting
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54 3 Pulmonary Drug Delivery: Deliv
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4 Cell Specific Delivery of Anti-In
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The sinusoids are lined by the disc
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4.2.2.2 Phagocytosis and Transcytos
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ther inflammatory cells or accessor
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4.3 Hepatic Inflammation and Fibros
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process is not yet available. Sever
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this carrier to the KCs.When the ma
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e taken up rapidly by mannose recep
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y the transcriptional regulatory pr
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4.8 Testing Liver Targeting Prepara
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4.8 Testing Liver Targeting Prepara
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4.9 Targeting of Anti-inflammatory
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4.9 Targeting of Anti-inflammatory
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with monoclonal and bispecific anti
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References 117 [50] Coleman DL, Eur
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References 119 [133] Cronstein BN,
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5 Delivery of Drugs and Antisense O
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5.1 Introduction 123 convoluted tub
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treatment of the targeted cell and
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CL uptake (ml/min/g) centration pro
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5.2.1.4 Specific Binding of Alkylgl
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5.2 Renal Delivery Using Pro-Drugs
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5.2 Renal Delivery Using Pro-Drugs
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5.3 Renal Delivery Using Macromolec
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5.4 Renal Delivary of Antisense Oli
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5.4 Renal Delivery of Antisense Oli
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5.4.8 Benefits and Limitations of A
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via reabsorption from the luminal s
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References 153 [66] Franssen EJF, M
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References 155 [145] Van Zwieten PA
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158 6 A Practical Approach in the D
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172 7 Vascular Endothelium in Infla
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8 Strategies for Specific Drug Targ
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8.2.2 Histogenesis The traditional
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may become obstructed and compresse
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8.5 Strategies to Deliver Drugs to
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8.5 Strategies to Deliver Drugs to
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larly cytotoxic immune effector cel
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contributes to limited tumour penet
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ples onto anti-EGP-2 scFv. Biologic
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In the case of drug-monoclonal anti
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cells, the presence of co-stimulato
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Monomethoxy-polyethylene glycol CH
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e efficiently loaded into the lipos
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8.6 Clinical Studies 223 Table 8.5.
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8.6.3 (Synthetic) (co)Polymers Solu
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8.8 Conclusions and Future Perspect
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References 229 [43] Chaouchi NA, Va
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References 231 [126] Czuczman MS, G
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234 9 Tumour Vasculature Targeting
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256 10 Phage Display Technology for
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11 Development of Proteinaceous Dru
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carrier is an homogenous product. I
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11.3 The Homing Device 11.3 The Hom
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malian cell lines that have acquire
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jugates for the delivery of other a
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11.5 The Linkage Between Drug and C
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actions are directed towards these
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11.5 The Linkage Between Drug and C
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homing potential if the antigen rec
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ly used promoters include T7 RNA po
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the baculovirus expression vector,
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11.8 Recombinant DNA Constructs 297
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11.8 Recombinant DNA Constructs 299
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toxic activity. Anthrax and tetanus
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11.9 Recombinant Domains as Buildin
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References 305 [16] Milstein C, Wal
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References 307 [99] Verma R, Boleti
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12 Use of Human Tissue Slices in Dr
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are also extensively used in a vari
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Meanwhile many incubation systems h
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12.3 Incubation and Culture of Live
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to investigate the effect of differ
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The mechanisms of uptake and excret
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12.6 The Use of Liver Slices in Dru
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12.7 Efficacy Testing of the Drug T
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NO x µM 80 60 40 20 * * 12.7 Effic
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TNFα ng/ml 1.5 1 0.5 0 * Human (n=
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References 329 [33] Ikejima K, Enom
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References 331 [109] Dutt A, Priebe
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334 13 Pharmacokinetic/Pharmacodyna
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372 14 Drug Targeting Strategy: Scr
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374 14 Drug Targeting Strategy: Scr
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