Drug Targeting Organ-Specific Strategies

Index
a
ADEPT 217, 224, 268, 291
adhesion molecules 93, 97, 172, 248
adhesion molecule targeting 81, 181, 182,
191, 248, 249
airways 55, 58
albumin, see proteins, modified
(plasma)
alkylglycoside targeting 126, 131
alveoli 55, 58
Alzheimer disease 23
amino acid pro-drug approach 132
angiogenesis 234
– and inflammation 175, 186, 234
– assays, in vitro 239
– assays, in vivo 240
– integrins, role of 236
– VEGF, role of 235
animal models (of disease)
– angiogenesis 190, 240
– atherosclerosis 190
– brain diseases 45
– brain uptake studies 31
– colonic delivery 160
– inflammation 189, 190
– inflammatory bowel disease 160, 189
– liver targeting 106, 109
– renal targeting 150
– rheumatoid arthritis 189
– tumor vasculature targeting 247, 248,
250
– tumor targeting 226
antibodies, (monoclonal) 3, 205, 207, 256,
278, 297
– affinity maturation 266
– bispecific 207, 215, 224, 247
– brain targeting 41
– clinical applications 11, 15, 221, 268
– diabodies 207, 267
– drug conjugates 213
– effector mechanisms 209
– endothelial cell targeting 17, 180, 246,
247, 249
– engineering 296
– engineering in phage display 267
– human(ized) antibodies 207, 211, 212,
222, 261, 268
Drug Targeting Organ-Specific Strategies. Edited by G. Molema, D. K. F. Meijer
Copyright © 2001 Wiley-VCH Verlag GmbH
ISBNs: 3-527-29989-0 (Hardcover); 3-527-60006-X (Electronic)
– immunocytokines 299
– immunoliposomes, see liposomes
– immunotoxins, see immunotoxins
– phage display 256
– pharmacokinetic modelling 364
– radioimmunoconjugates 181, 215, 246,
249, 364
– scFv 211, 260, 297
– tumor (endothelial) cell targeting 205,
209, 246, 247, 249, 268
antisense oligodeoxynucleotides
– brain targeting 46
– cellular handling 147
– pharmacologic activity 145, 185
– pharmacokinetics 146, 362
– renal targeting 144, 148
– stabilization 145
apoptosis
– in inflammation 173
– in antibody therapy 210
aprotinine 140
arginine vasopressin targeting 126
asialoglycoprotein receptors 91
assembly domains 303
asthma 53, 77, 175
atherosclerosis, see inflammation
avidin-biotin linker technology 43
b
baculovirus expression system 294
biodegradable linkers 287
blood-brain barrier 23, 26
blood-cerebrospinal fluid barrier 26
blood coagulation, targeted induction of
247
brain 23
– brain uptake index 31
– architecture 26
– CNS diseases 23pp
– drug targeting to 34pp
– pharmacologic drug delivery strategies
40
– physical drug delivery strategies 36
– in vitro models 34
– in vivo models 31
– receptor mediated uptake systems 29
– transport systems 28