Drug Targeting Organ-Specific Strategies

treatment of the targeted cell and because of that, may improve the therapy when given in
combination with the conventional treatment.
5.1.5 Targeting to the Proximal Tubular Cell
5.1 Introduction 125
Figure 5.2. Pathogenic mechanisms that are potentially involved in tubulointerstitial fibrogenesis in
glomerular kidney disorders. Reprinted with permission from reference [19].
In this chapter, three aspects of drug targeting to the proximal tubular cell will be discussed
in the light of recent advances in this field. First, various pro-drug concepts designed for selective
renal delivery with emphasis on the use of alkylglycoside vectors, will be described.
Subsequently, the use of low-molecular weight proteins as potential drug carriers will be dis-