330 12 Use of Human Tissue Slices in <strong>Drug</strong> <strong>Targeting</strong> Research [72] Leeman WR, van de Gevel IA, Rutten AAJJL, Toxicol. In Vitro 1995, 9, 291–298. [73] de Kanter R, Olinga P, de Jager MH, Merema MT, Meijer DKF, Groothuis GMM, Toxicol. In Vitro 1999, 13, 737–744. [74] de Kanter R, Olinga P, Hof I, de Jager M, Verwillegen WA, Slooff MJ, Koster HJ, Meijer DK, Groothuis GM, Xenobiotica 1998, 28, 225–234. [75] Olinga P, Merema M, Hof IH, de Jong KP, Slooff MJH, Meijer DKF, Groothuis GMM, <strong>Drug</strong> Metab. Dispos. 1998, 26, 5–11. [76] Valentovic MA, Ball JG, Anestis DK, Rankin GO, Toxicol. In Vitro 1995, 9, 75–81. [77] Miller MG, Beyer J, Hall GL, Degraffenried LA, Adams PE, Toxicol. Appl. Pharmacol. 1993, 122, 108–116. [78] Olinga P, Merema MT, Hof IH, De Jager MH, De Jong KP, Slooff MJH, Meijer DKF, Groothuis GMM, Xenobiotica 1998, 28, 349–360. [79] Jansen RW, Olinga P, Harms G, Meijer DKF, Pharm. Res. 1993, 10, 1611–1614. [80] Sutto F, Brault A, Lepage R, Huet P-M, J. Hepatol. 1994, 20, 611–616. [81] Olinga P, Hof IH, Smit M, de Jager MH, Nijenhuis E, Slooff MJH, Meijer DKF, Groothuis GMM, J. Pharm. Toxicol. Methods, 2001 (in press). [82] Oude Elferink RPJ, Meijer DKF, Kuipers F, Jansen PLM, Groen AK, Groothuis GMM, Biochim. Biophys. Acta 1995, 1241, 215–268. [83] Tiribelli C, Reichen J, Meijer DKF, J. Hepatol. 1996, 24, 11–34. [84] Meijer DKF, In: Handbook of Physiology. The Gastrointestinal System, Vol. III (Eds Schulz J, Forte G, Rauner BB), pp. 717–758. Oxford University Press, New York, 1989. [85] Meijer DKF, Ziegler K, In: Biological Barriers to Protein Delivery (Eds Audus KL, Raub TJ), pp. 339–407. Plenum Press, New York and London, 1993. [86] Jansen RW, Kruijt JK, van Berkel TJ, Meijer DK, Hepatology 1993, 18, 146–152. [87] Olinga P, Merema MT, Hof IH, Slooff MJH, Proost JH, Meijer DKF, Groothuis GMM, J. Pharmacol. Exp. Ther. 1998, 285, 506–510. [88] Sandker GW, Weert B, Olinga P, Wolters H, Slooff MJH, Meijer DKF, Groothuis GMM, Biochem. Pharmacol. 1994, 47, 2193–2200. [89] Schanker LS, Solomon HM, Am. J. Physiol. 1963, 204, 829–832. [90] Hedman A, Meijer DKF, J. Pharm. Sci. 1998, 87, 457–461. [91] Hedman A, Meijer DK, J. Hepatol. 1998, 28, 240–249. [92] Olinga P, de Kanter R, Hof IH, de Jager MH, Slooff MJH, Koster HJ, Meijer DKF, Groothuis GMM, Hepatology 1996, 24, 468A. [93] Thompson MB, Davis DG, Morris RW, J. Lipid Res. 1993, 34, 553–561. [94] Beljaars L, Molema G, Weert B, Bonnema H, Olinga P, Groothuis GMM, Meijer DKF, Poelstra K, Hepatology 1999, 29, 1486–1493. [95] Beljaars L, Molema G, Schuppan D, Geerts A, De Bleser PJ, Weert B, Meijer DKF, Poelstra K, J. Biol. Chem. 2000, 275, 12743–12751. [96] Aono K, Isobe K, Kiuchi K, Fan ZH, Ito M, Takeuchi A, Miyachi M, Nakashima I, Nimura Y, J. Cell Biochem. 1997, 65, 349–358. [97] Van Bossuyt H, De Zanger RB, Wisse E, J. Hepatol. 1988, 7, 325–337. [98] Billiar TR, Curran RD, Ferrari FK, Williams DL, Simmons RL, J. Surg. Res. 1990, 48, 349–353. [99] Vos TA, Gouw AS, Klok PA, Havinga R, van Goor H, Huitema S, Roelofsen H, Kuipers F, Jansen PL, Moshage H, Gastroenterology 1997, 113, 1323–1333. [100] Nussler AK, Di Silvio M, Liu ZZ, Geller DA, Freeswick P, Dorko K, Bartoli F, Billiar TR, Hepatology 1995, 21, 1552–1560. [101] Luster MI, Germolec DR, Yoshida T, Kayama F, Thompson M, Hepatology 1994, 19, 480–488. [102] Sultan K, Hartung J, Bade EG, FEBS Lett. 1996, 394, 51–54. [103] Melgert BN, Olinga P, Jack VK, Molema G, Meijer DKF, Poelstra K, J. Hepatol. 2000, 32, 603–611. [104] Olinga P, Merema MT, de Jager MH, Slooff MJH, Limburg PC, Bijzet J, Poelstra K, Meijer DKF, Groothuis GMM, Hepatology 1998, 28, 184A. [105] Stijntjes GJ, Commandeur JN, te Koppele JM, McGuinness S, Gandolfi AJ, Vermeulen NP, Toxicology 1993, 79, 67–79. [106] Vickers AEM, Fisher RL, Brendel K, Guertler J, Dannecker R, Keller B, Fischer V, <strong>Drug</strong> Metab. Dispos. 1995, 23, 327–333. [107] Foulkes EC, Proc. Soc. Exp. Biol. Med. 1996, 211, 155–162. [108] Ruegg CE, Gandolfi AJ, Nagle RB, Krumdieck CL, Brendel K, J. Pharmacol. Methods 1987, 17, 111–123.
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Drug Targeting Organ-Specific Strat
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Drug Targeting Organ-Specific Strat
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Preface Drug Targeting Organ-Specif
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Foreword Drug Targeting Organ-Speci
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X List of Contributors Henderik W.
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XII List of Contributors Grietje Mo
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Contents Drug Targeting Organ-Speci
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Contents XVII 3 Pulmonary Drug Deli
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Contents XIX 5.2.1.6 Identification
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Contents XXI 7.5 In Vitro Technique
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Contents XXIII 9.4 Tumour Vasculatu
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Contents XXV 12.8. Tissue Slices fr
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Drug Targeting Organ-Specific Strat
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Dexa dexamethasone DIVEMA divinyl e
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LRP lung resistance related protein
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ROS reactive oxygen species RSV res
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Index a ADEPT 217, 224, 268, 291 ad
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e E. coli expression system 292 eff
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polymers, soluble 4, 218 - dendrime
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2 1 Drug Targeting: Basic Concepts
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4 1 Drug Targeting: Basic Concepts
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6 1 Drug Targeting: Basic Concepts
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8 1 Drug Targeting: Basic Concepts
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10 1 Drug Targeting: Basic Concepts
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12 1 Drug Targeting: Basic Concepts
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22 1 Drug Targeting: Basic Concepts
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24 2 Brain-Specific Drug Targeting
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26 2 Brain-Specific Drug Targeting
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28 2 Brain-Specific Drug Targeting
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30 2 Brain-Specific Drug Targeting
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32 2 Brain-Specific Drug Targeting
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34 2 Brain-Specific Drug Targeting
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36 2 Brain-Specific Drug Targeting
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38 2 Brain-Specific Drug Targeting
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40 2 Brain-Specific Drug Targeting
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42 2 Brain-Specific Drug Targeting
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44 2 Brain-Specific Drug Targeting
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46 2 Brain-Specific Drug Targeting
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48 2 Brain-Specific Drug Targeting
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50 2 Brain-Specific Drug Targeting
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52 2 Brain-Specific Drug Targeting
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54 3 Pulmonary Drug Delivery: Deliv
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56 3 Pulmonary Drug Delivery: Deliv
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58 3 Pulmonary Drug Delivery: Deliv
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60 3 Pulmonary Drug Delivery: Deliv
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70 3 Pulmonary Drug Delivery: Deliv
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72 3 Pulmonary Drug Delivery: Deliv
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78 3 Pulmonary Drug Delivery: Deliv
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84 3 Pulmonary Drug Delivery: Deliv
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86 3 Pulmonary Drug Delivery: Deliv
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4 Cell Specific Delivery of Anti-In
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The sinusoids are lined by the disc
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4.2.2.2 Phagocytosis and Transcytos
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ther inflammatory cells or accessor
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4.3 Hepatic Inflammation and Fibros
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process is not yet available. Sever
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this carrier to the KCs.When the ma
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e taken up rapidly by mannose recep
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y the transcriptional regulatory pr
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4.8 Testing Liver Targeting Prepara
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4.8 Testing Liver Targeting Prepara
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4.9 Targeting of Anti-inflammatory
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4.9 Targeting of Anti-inflammatory
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with monoclonal and bispecific anti
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References 117 [50] Coleman DL, Eur
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References 119 [133] Cronstein BN,
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5 Delivery of Drugs and Antisense O
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5.1 Introduction 123 convoluted tub
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treatment of the targeted cell and
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CL uptake (ml/min/g) centration pro
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5.2.1.4 Specific Binding of Alkylgl
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5.2 Renal Delivery Using Pro-Drugs
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5.2 Renal Delivery Using Pro-Drugs
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5.3 Renal Delivery Using Macromolec
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5.3 Renal Delivery Using Macromolec
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5.3 Renal Delivery Using Macromolec
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5.3 Renal Delivery Using Macromolec
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5.3 Renal Delivery Using Macromolec
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5.4 Renal Delivary of Antisense Oli
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5.4 Renal Delivery of Antisense Oli
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5.4.8 Benefits and Limitations of A
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via reabsorption from the luminal s
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References 153 [66] Franssen EJF, M
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References 155 [145] Van Zwieten PA
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158 6 A Practical Approach in the D
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160 6 A Practical Approach in the D
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162 6 A Practical Approach in the D
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164 6 A Practical Approach in the D
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166 6 A Practical Approach in the D
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168 6 A Practical Approach in the D
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170 6 A Practical Approach in the D
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172 7 Vascular Endothelium in Infla
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174 7 Vascular Endothelium in Infla
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176 7 Vascular Endothelium in Infla
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178 7 Vascular Endothelium in Infla
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180 7 Vascular Endothelium in Infla
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182 7 Vascular Endothelium in Infla
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184 7 Vascular Endothelium in Infla
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186 7 Vascular Endothelium in Infla
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188 7 Vascular Endothelium in Infla
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190 7 Vascular Endothelium in Infla
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192 7 Vascular Endothelium in Infla
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194 7 Vascular Endothelium in Infla
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196 7 Vascular Endothelium in Infla
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8 Strategies for Specific Drug Targ
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8.2.2 Histogenesis The traditional
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may become obstructed and compresse
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8.5 Strategies to Deliver Drugs to
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8.5 Strategies to Deliver Drugs to
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larly cytotoxic immune effector cel
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contributes to limited tumour penet
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ples onto anti-EGP-2 scFv. Biologic
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In the case of drug-monoclonal anti
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cells, the presence of co-stimulato
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Monomethoxy-polyethylene glycol CH
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e efficiently loaded into the lipos
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8.6 Clinical Studies 223 Table 8.5.
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8.6.3 (Synthetic) (co)Polymers Solu
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8.8 Conclusions and Future Perspect
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References 229 [43] Chaouchi NA, Va
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References 231 [126] Czuczman MS, G
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234 9 Tumour Vasculature Targeting
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236 9 Tumour Vasculature Targeting
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238 9 Tumour Vasculature Targeting
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240 9 Tumour Vasculature Targeting
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242 9 Tumour Vasculature Targeting
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244 9 Tumour Vasculature Targeting
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246 9 Tumour Vasculature Targeting
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248 9 Tumour Vasculature Targeting
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250 9 Tumour Vasculature Targeting
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252 9 Tumour Vasculature Targeting
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254 9 Tumour Vasculature Targeting
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256 10 Phage Display Technology for
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258 10 Phage Display Technology for
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260 10 Phage Display Technology for
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262 10 Phage Display Technology for
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264 10 Phage Display Technology for
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266 10 Phage Display Technology for
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268 10 Phage Display Technology for
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270 10 Phage Display Technology for
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272 10 Phage Display Technology for
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11 Development of Proteinaceous Dru
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carrier is an homogenous product. I
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