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Traditional Medicine in Asia

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to give priority to research and development<br />

of traditional medic<strong>in</strong>es. The health<br />

policy of Ch<strong>in</strong>a aims at <strong>in</strong>tegrat<strong>in</strong>g modern<br />

medic<strong>in</strong>e with the traditional Ch<strong>in</strong>ese<br />

medic<strong>in</strong>es and conduct<strong>in</strong>g research <strong>in</strong><br />

traditional practices <strong>in</strong> a rational way. India<br />

has set up the Central Council for Research<br />

<strong>in</strong> Ayurveda and Siddha (CCRAS) and<br />

Unani systems to <strong>in</strong>vestigate a number of<br />

herbal medic<strong>in</strong>es to establish the scientific<br />

basis of their use. The Indian Council of<br />

Medical Research has established a<br />

programme of Composite Drug Research<br />

(CDR) whereby herbal drugs are <strong>in</strong>vestigated<br />

by a team of traditional and modern<br />

medic<strong>in</strong>e practitioners, a botanist, a<br />

phytochemist and a pharmacologist <strong>in</strong> a<br />

coord<strong>in</strong>ated manner.<br />

More than a hundred medic<strong>in</strong>al plants<br />

used <strong>in</strong> Ayurveda have been <strong>in</strong>vestigated<br />

<strong>in</strong> the CDR scheme and have provided<br />

some promis<strong>in</strong>g leads for further<br />

<strong>in</strong>vestigation. In some cases, the therapeutic<br />

claims made by Ayurveda practitioners<br />

have been justified by pharmacological<br />

studies. The plants selected <strong>in</strong> CDR<br />

have been botanically identified and their<br />

pharmacognostic data have been<br />

reported. Phytochemical studies have<br />

yielded some novel chemical structures. 2<br />

Thus, the Satavari (Asparagus racemosus)<br />

root used <strong>in</strong> Ayurveda as a galactogogue<br />

was studied <strong>in</strong> experimental animals and<br />

reported to possess galactogogue and<br />

anti-oxytosic activities. (3,4) The plant is<br />

reported to conta<strong>in</strong> Shatavar<strong>in</strong> hav<strong>in</strong>g a<br />

specific pharmacological action. Picrorhiza<br />

kurroa has been reported to posses<br />

hepatoprotective activity and its active<br />

pr<strong>in</strong>ciples have been identified as<br />

Picrocytes. Butea frondosa, which is used<br />

<strong>in</strong> Ayurvedic preparations as an anthelm<strong>in</strong>tic,<br />

has yielded an active pr<strong>in</strong>ciple called<br />

palason<strong>in</strong>. Guggulisterone from guggul<br />

res<strong>in</strong> has been isolated. 2 The res<strong>in</strong> is used<br />

Research, drug development and manufacture of herbal drugs<br />

extensively by traditional practitioners <strong>in</strong> the<br />

treatment of <strong>in</strong>flammation of jo<strong>in</strong>ts, obesity,<br />

lipid disorders, etc., on the basis of the<br />

description of Medorog (Lipid disorder) by<br />

Susruta. Chemical <strong>in</strong>vestigation has yielded<br />

two active compounds, namely z-<br />

Guggulsterone and e-Guggulsterone. 5 It<br />

is evident that such a composite approach<br />

<strong>in</strong> the <strong>in</strong>vestigation of medic<strong>in</strong>al plants is<br />

likely to be more reward<strong>in</strong>g <strong>in</strong> establish<strong>in</strong>g<br />

the therapeutic claims of traditional<br />

remedies and obta<strong>in</strong><strong>in</strong>g novel chemical<br />

entities.<br />

Thailand, Indonesia, Vietnam, Sri Lanka<br />

and Nepal, have all given priority to<br />

research <strong>in</strong> traditional medic<strong>in</strong>es <strong>in</strong> their<br />

health and drug policies. Several countries<br />

have established pharmacopoeias of<br />

traditional medic<strong>in</strong>es and established<br />

<strong>in</strong>stitutes to undertake research <strong>in</strong> all<br />

aspects, <strong>in</strong>clud<strong>in</strong>g standardization and<br />

quality control of herbal medic<strong>in</strong>es.<br />

Objectives of Research <strong>in</strong><br />

Herbal <strong>Medic<strong>in</strong>e</strong>s<br />

The hallmark of modern medic<strong>in</strong>e is the<br />

scientific approach <strong>in</strong> promot<strong>in</strong>g health,<br />

prevent<strong>in</strong>g diseases and cur<strong>in</strong>g ailments.<br />

Scientific methodology consists of the<br />

follow<strong>in</strong>g approaches:<br />

� Astute observation;<br />

� Formation of hypothesis;<br />

� Experimentation to prove or reject the<br />

hypothesis;<br />

� Acceptance and <strong>in</strong>corporation of the<br />

results of research <strong>in</strong> modern medic<strong>in</strong>e.<br />

S<strong>in</strong>ce most herbal medic<strong>in</strong>es used <strong>in</strong><br />

traditional practices are based on<br />

empiricism, there is a need to separate<br />

chaff from the gra<strong>in</strong> and prove, beyond<br />

reasonable doubt, the efficacy, safety and<br />

cost-effectiveness of herbal medic<strong>in</strong>es. Such<br />

an approach not only enriches modern<br />

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