full report - UCT - Research Report 2011

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244 GRANTED AChAryA, k.r. AND SturroCk, e.D. Crystal structure of an angiotensin-converting enzyme (ACE) and uses thereof. Divisional Patent United States 7,901,507. ChibAle, k., NChiNDA, A.t. AND SturroCk, e.D. Angiotensin I-converting enzyme (ACE) inhibitors. National Phase Patent Australia 2006250905. ChibAle, k., NChiNDA, A.t. AND SturroCk, e.D. Angiotensin I-converting enzyme (ACE) inhibitors. National Phase Patent Australia 2006250906. ChibAle, k., NChiNDA, A.t. AND SturroCk, e.D. Angiotensin I-converting enzyme (ACE) inhibitors. National Phase Patent United States 7,981,922. DouglASS, N., SheN, y.-J. AND williAmSoN, A-l. Recombinant lumpy skin disease virus for preventing AIDS. National Phase Patent South Africa 2010/03806 vAN Der merwe, w.m. AND wilSoN, D.A.J. A surgical drill aimer. National Phase Patent South Africa 2011/02343. RESEARCH CONTRACTS 507 VALUE OF RESEARCH CONTRACTS r409,42 million NRF-RATED RESEARCHERS 86 SARCHI RESEARCH CHAIRS 8 ACCREDITED RESEARCH GROUPINGS 21 DOCTORAL GRADUATIONS 52 ERP PARTICIPANTS 121 DHET-ACCREDITED JOURNALS 378.07 units PEER-REVIEWED PUBLICATIONS 1 240 FILED PATENTS 34 GRANTED PATENTS 6 POSTGRADUATE STUDENTS 1 470 POSTGRADUATE FUNDING r29,12 million POSTDOCTORAL RESEARCH FELLOWS 92 POSTDOCTORAL RESEARCH FUNDING r18,37 million UCT ReseARCh RepORT '11
Department of anaesthesia heAD oF DePArtmeNt: ProFeSSor mFm JAmeS DePArtmeNtAl ProFile clinical research: Fluid therapy has continued to be a major area of interest within the Department. The FIRST (Fluids in resuscitation of severe trauma) trial was published in a major journal this year and a number of research projects have resulted from that. In particular, studies on the anion composition of various intravenous fluids have been commenced in collaboration with University College London and this project is now approximately halfway completed. Further intravenous fluid therapy studies have included the development of a semi-automated fluid administration system for patients unable to maintain their own natural fluid balance. This project known as the “Quench” project is being developed jointly between the UCT and University College London Department of anaesthesia and critical care. A major systematic review is being undertaken jointly between Prof James, Prof Mythen (UCL), Prof van der Linden (Belgium) and Dr Richard Weiskopf (UCL) on the role of intravenous hydroxyethyl starch in the perioperative period. A second important area of investigation is Obstetric Anaesthesia. New projects were initiated in the study of spinal anaesthesia in preeclamptic parturients. One study will investigate the effects of vasopressor therapy pre-delivery on neonatal acid-base status in patients with a non-reassuring fetal heart trace. A second study will examine three aspects of spinal anaesthesia, namely stroke volume responsiveness prior to spinal anaesthesia, the haemodynamic effects of the vasopressor therapy prior to delivery, and the effects of various methods of administering oxytocin, including the interaction with an alpha-agonist. For this purpose, a non-invasive cardiac output device will be employed, using an algorithm based upon pulse wave form analysis. As part of these investigations, a collaboration was initiated with the Department of Anaesthesia of the University of Washington. This aspect of the study will examine the population characteristics of the adrenaline β2-haplotype in preeclamptic women. At the same time data would be collected on control healthy women. At least three MMed mini-dissertations will arise from this work. One of the investigators represented the Department at the Obstetric Anaesthetists’ Association annual 3 day course in London. A further study validating the use of a non-invasive cardiac output device in patients with complicated severe preeclampsia, was accepted by the British Journal of FACULTY OF heALTh sCienCes Anaesthesia. In addition, a prospective audit of epidural analgesia was completed and analysed. The leader of this research group, Professor RA Dyer, has applied for NRF rating on the basis of 22 publications and a PhD in this area during the period of review from 2004-2011. The refurbishment of the Red Cross Hospital operating theatre complex continued to create an environment conducive to research, and this was evidenced by the publication of several instructive case reports, and an important study of the pharmacokinetics of ketamine in children, following oral administration, in the journal Paediatric Anaesthesia. Several new projects are in preparation, including a pharmacokinetic study of the antimicrobial agent cefazolin during cardiopulmonary bypass. Co-operation in these studies has been obtained from the Department of Pharmacology, including the development of an assay for cefazolin, which should form the basis of several further important clinical trials. Important projects in thromboelastography are ongoing. Valuable guidelines have been published for pain management and sedation in children. The Department is an active research site for the international, multicentre POISE-2 trial of aspirin and clonidine for perioperative protection of high risk patients against perioperative myocardial events, and has recruited the second highest number of patients in South Africa. The South African principal investigator is Dr B. Biccard, from the Department of Anaesthesia, UKZN. The local site was initially set up by Prof M. James. The lead author is Dr A. Myburgh, with Drs O Porrill and A Emmanuel as co-investigators. laboratory research: The Department was involved in 3 major areas of research in 2011. Firstly, there are ongoing studies on coagulation, both clinical, which resulted in a paper in Anaesthesia, and an animal study of coagulation in a porcine model of acute liver failure. Cardiac output measurements were also obtained in the latter study. Secondly, transoesophageal echocardiography is being performed in baboons undergoing valve replacement. collaboration: Once again, junior consultants and registrars were encouraged to participate in research activities wherever possible, and scientific writing skills were also improved in this way. International collaboration continues, with the University College London Hospitals, Stanford University, the Rikshospitalet, Oslo, the University of Toronto, and the University of Washington. 245
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20 11 University of Cape Town Resea
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2 Our Mission Statement UCT aspires
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4 UCT RESEARCH REPORT '11
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6 New UCT Fellow Professor Vanessa
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8 Professor Hans-Peter Kunzi was on
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10 NRF A-rated researcher Professor
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12 Dr Thomas Scriba, a finalist in
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14 Department of Research and Innov
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16 Research Contracts and Intellect
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18 NSTF-BHP BILLITON 2011/12 WINNER
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20 Research funding is often used a
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22 SA Government Public Entities an
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24 international students at UCT ha
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26 Degree Awards Departmental funds
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28 Source Awards Non-SADC Internati
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30 POSTDOCTORAL RESEARCH FELLOWS (P
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32 Celebrating our new A- and P-rat
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34 Dr David Braun: Researching the
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36 NRF-rated researchers at UCT dur
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38 DST/NRF SARChI CHAIRS AT UCT Ani
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40 the signature themes are grounde
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42 From the lab to the market: cutt
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44 Drug and vaccine discovery given
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46 Testing the waters The Aquatest
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48 Dr George Vicatos, a mechanical
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50 Research themes CLIMATE CHANGE A
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52 Climate change UCT ReseaRCh Repo
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54 UCT launches a co-ordinated assa
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56 signature themes associated with
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58 Research groupings associated wi
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60 DsT/nRF saRChI Chairs associated
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62 astronomy UCT ReseaRCh RepoRT '1
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64 It’s written in the stars: Sou
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66 “Each of the (MeerKAT) project
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68 social and economic relevance UC
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70 The business of integrating rese
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74 Water research UCT ReseaRCh Repo
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76 UCT researchers combine to prote
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78 Research grouping associated wit
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80 Burden of disease UCT ReseaRCh R
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82 A big-picture view to reduce the
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84 signature theme associated with
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90 DsT/NRF saRChI Chairs associated
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92 Computing power UCT ReseaRCh Rep
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94 The many applications of computi
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98 “The HPC node ran its first UC
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100 poverty and economics UCT Resea
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102 Turning the tide on poverty Whe
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104 Research groupings associated w
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106 grants or other social spending
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108 engineering the economy UCT Res
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110 From resources to knowledge: th
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112 UCT’s Minerals to Metals rese
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114 Competence centre associated wi
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118 human biology UCT ReseaRCh Repo
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120 In praise and pursuit of the hu
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122 Research grouping associated wi
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124 physics UCT ReseaRCh RepoRT '11
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126 Solving the mysteries of the Un
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130 humanities footprint UCT ReseaR
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132 Making the case for humanities
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138 Brain behaviour UCT ReseaRCh Re
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140 The science of substance abuse
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144 DsT/NRF saRChI Chairs associate
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146 Urban challenges UCT ReseaRCh R
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148 Creating healthy and resilient
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152 Environment: the Centre for Tra
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154 The Constitution UCT ReseaRCh R
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156 Public values and private right
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160 DsT/NRF saRChI Chairs associate
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162 Research without borders UCT Re
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164 UCT stakes its claim on the int
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166 and must fulfill at least one o
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168 Research support UCT ReseaRCh R
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170 Looking after a new generation
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172 ways of generating new knowledg
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174 Faculty of Engineering & the Bu
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176 profile collaboration network,
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178 lewis, a.e. and naTHOO, J.a. Me
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180 scHOOl sTaTisTics permanent and
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182 governance. In O. Bodin and C.
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184 exhibitions Todeschini, F. 2011
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186 pOsTdOcTOral FellOws dr Mayeli
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188 Govender, I., Mangesana, N., Ma
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190 Mwase, J., Petersen, J. and Eks
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192 Bbosa, L.S., Govender, I., Main
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294 study that explores the capacit
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296 mS ShAmilA mANie Intensive Care
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298 Jelsma, J.M., Davids, N. and Fe
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300 South Africa’s most important
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302 ASSoCiAte ProFeSSor mArJANNe Se
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304 Dr roSS tuCker RUESSM: Research
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306 Hemmerich, A., van der Merwe, W
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308 O’Connell, K., Posthumus, M.
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310 Annual ISMRM Scientific Meeting
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312 reSeArCh FielDS AND StAFF ASSoC
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314 Develop, evaluate and implement
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316 CoNtACt DetAilS Postal Address:
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318 the AlbertiNA AND wAlter SiSulu
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320 DiviSioN oF Neurology heAD oF D
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322 diseases unit provides inpatien
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324 G., Allwood, B., Dawson, R. and
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326 Gabriels, G.A., Lambert, M.I.,
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328 antiretroviral therapy in South
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330 Are interferon- release assays
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332 Opie, L.H. 2011. Glycaemia and
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334 Cornick, R., Faris, G.F. and Dr
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336 of Serum C-Reactive Protein as
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338 Dr ANNe horAk High risk obstetr
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340 primary health care Directorate
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342 child and adolescent psychiatry
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344 of adverse effect in fetal alco
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346 Stein, D.J., Bandelow, B., Meri
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348 Further, in addition to subsidy
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350 pesticide risk management is st
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352 • Two senior staff members ob
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354 system; human rights issues in
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356 Schuur Hospital, Cape Town, dur
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358 Harris, B., Goudge, J., Ataguba
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360 Mann, g., Thomson, R., Jin, C.,
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362 and Zwarenstein, M. 2011. From
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364 assistant managers (medical phy
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366 contract research staff part-ti
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368 de Boer, R.H., Arrieta, O., Yan
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370 segment surgery, corneal diseas
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372 DiviSioN oF emergeNCy meDiCiNe
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374 students Doctoral 1 master’s
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376 CoNtACt DetAilS Postal Address:
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378 permanent and long term contrac
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380 auxilliary artery injuries. Sou
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382 Van Zyl, L. 2011. Severe bilate
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384 host of the world-renowned Jame
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386 m. mutowo (graDuatE School of B
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388 aSSociatE profESSor JEnnifEr ro
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390 rESEarch fiElDS anD Staff perma
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392 Suleman (eds), Proceedings of S
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394 Steyn and E.M. Villeneuva (eds)
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396 Since 1999 SALDRU has run the a
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398 profESSor anthony Black Develop
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400 mr DaviD (chEn-wEi) tSEng Labou
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402 articles in peer-reviewed Journ
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406 school statistics professors 4
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408 Raubenheimer, H. 2011. Constrai
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410 South African women’s magazin
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412 Africa Can, pp. 371-399. Washin
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414 Faculty of Humanities Dean’s
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416 South African Art in Context Vo
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418 n. mAmmon (EnviRonmEntAl And gE
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420 REsEARch outPut edited books Ok
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422 AssociAtE PRofEssoR lEslEy mARx
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424 Ndlovu, M.W. 2011. The meaning
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426 chapters in books Alexander, J.
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428 Collection, Neu-Ulm/Burlafingen
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430 REsEARch outPut articles in pee
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432 Dance International: Produced a
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434 Mahali, A. 2011. “Piecing tog
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436 PRofEssoR johAn mullER Curricul
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438 peer-reviewed published confere
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440 EmERitus PRofEssoR gEoffREy hug
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442 Schalkwyk, D.J. 2011. The impos
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444 Pissarra, M., Goniwe, T. and Ma
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446 and Cinema in Francophone West
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448 Hambidge, J.H. 2011. Alle grapp
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450 mR. williAm hAuBRich Brass, par
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452 Hofmeyr, H.P. 2011. Il poeta e
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454 Grace, J. 2011. “Concert in t
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456 Liebl, L.B. 2011. Carmina Buran
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458 Van Schalkwyk, A. 2011. Liszt 2
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460 Wanderer, J.R. 2011. On Vice an
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462 Cameron, R.G. and Milne, C. 201
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464 Carr, S.C., Bandawe, C.R., Mart
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466 Department of religious stuDies
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468 Mobilising Religious Health Ass
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470 PRof cARolyn hAmilton National
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472 Department of social DeVelopmen
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474 pedagogics in higher education;
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476 Sitas, A. 2011. The moving blac
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478 Steinberg, J. 2011. A bag of so
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480 AIDS policy, AIDS denialism; AI
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482 Faculty of Science Dean’s rep
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484 in Professor Kevin Naidoo, Prof
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486 m.f. munyololo (Chemistry) New
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488 britton, d.t. And hÄrtinG, m.
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490 emeritus professors professor n
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492 Department of astronomy (Includ
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494 reseArCh output articles in pee
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496 De Blok, W.J.G. 2011. The MeerK
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498 students postdoctoral 4 doctora
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500 February, E.C., Allsopp, N., Sh
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502 Schutz, A., Bond, W.J. and Cram
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504 AssoCiAte professor dAvid W. GA
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506 Cabrera, D.G., Douelle, F., Fen
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508 and Heck cross-coupling reactio
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510 secure data storage on the web.
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512 Kapuire, G. and Blake, E.H. 201
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514 has established itself as a cen
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516 dr Chris lennArd Atmospheric sc
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518 developing world fisheries. Law
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520 reseArCh output edited books Fa
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522 Rowe, C. and Backeberg, N. 2011
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524 dr mArGAret ArChibAld Lecturer;
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526 articles in peer-reviewed Journ
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528 Ellis, G.F.R. 2011. Shear free
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530 Uzan, J., Ellis, G.F.R. and Lar
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532 students post-doctoral 10 docto
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534 Galvao, B., Meggersee, R.L. and
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536 feather disease virus isolates.
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538 dr s. sWArt Southern ocean Biog
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540 Shillington, F.A. 2011. Johann
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542 professor f.e. lubben Physics E
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544 Govender, I., Mangesana, N., Ma
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546 professor GrAhAm bArr Econometr
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548 Newling, J., Varughese, M., Bas
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550 depArtmentAl stAtistiCs permane
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552 Honorary professors professor d
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554 ContACt detAils Tel: +27 21 650
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556 Blattodea), with placement of a
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558 Marchante, H., Freitas, H. and
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560 a description of a new species
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562 Zetlmeisl, C., Hermann, J., Pet
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564 A new generation of university
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566 aCaDemIC DeVeLopment proGramme
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568 Dr howArD PeArCe Senior Lecture
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570 into entrepreneurial ventures:
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572 Centre For InFormatIon LIteraCY
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574 ASSoCIATe ProfeSSor SueLLen ShA
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576 UCT REsEARCH REPORT '11
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