full report - UCT - Research Report 2011

Dumitrascu, F., Caira, M.R., Georgescu, E., Georgescu,
F., Draghici, C. and Popa, M.M. 2011. Generation
of pyrrolo[2,1-a]isoquinoline derivatives from N-ylides:
synthetic control and structural characterization.
Heteroatom Chemistry, 22(6): 723-729.
Fehér, K., Matthews, R.P., Kövér, K.E., Naidoo, K.J.
and Szilágyi, L. 2011. Conformational preferences in
diglycosyl disulfides: NMR and molecular modeling
studies. Carbohydrate Research, 346: 2612-2621.
Feng, T.-S., Guantai, E.M., Nell, M.J., van Rensburg,
C.E.J., Hoppe, H.C. and Chibale, K. 2011. Antiplasmodial
and antitumor activity of dihydroartemisinin analogs
derived via the aza-Michael addition reaction. Bioorganic
& Medicinal Chemistry Letters, 21: 2882-2886.
Feng, T.-S., Guantai, E.M., Nell, M., van Rensburg,
C.E.J., Ncokazi, K., Egan, T.J., Hoppe, H.C. and Chibale,
K. 2011. Effects of highly active novel artemisininchloroquinoline
hybrid compounds on β-hematin
formation, parasite morphology and endocytosis in
Plasmodium falciparum. Biochemical Pharmacology,
82: 236-247.
Fucke, K., Anderson, K.M., Filby, M.H., Henry, M., Wright,
J., Mason, S.A., Gutmann, M.J., Barbour, L.J., Oliver, C.,
Coleman, A.W., Atwood, J.L., Howard, J.A.K. and Steed,
J.W. 2011. The structure of water in p-sulfonatocalix[4]
arene. Chemical European Journal, 17: 10259-10271.
Glans, L., Taylor, D., de Kock, C., Smith, P.J., Haukka,
M., Moss, J.R. and Nordlander, E. 2011. Synthesis,
characterization and antimalarial activity of new
chromium arene-quinoline half sandwich complexes.
Journal of Inorganic Biochemistry, 105: 985-990.
Govender, P., Renfrew, A.K., Clavel, C.M., Dyson, P.J.,
Therrien, B. and Smith, G.S. 2011. Antiproliferative
activity of chelating N,O- and N,N-ruthenium(II)
arene functionalised poly(propyleneimine) dendrimer
scaffolds. Dalton Transactions, 40: 1158-1167.
Guantai, E.M., Ncokazi, K., Egan, T.J., Gut, J., Rosenthal,
P.J., Bhampidipati, R., Kopinathan, A., Smith, P.J. and
Chibale, K. 2011. Enone- and chalcone-chloroquinoline
hybrid analogues: in silico guided design, synthesis,
antiplasmodial activity, in vitro metabolism, and
mechanistic studies. Journal of Medicinal Chemistry,
54: 3637-3649.
Guantai, E. and Chibale, K. 2011. How can natural
products serve as a viable source of lead compounds
for the development of new/novel anti-malarials? Malaria
Journal, 10(suppl 1):S2
Hans, R.H., Wiid, I.J.F., van Helden, P.D., Wan, B.,
Franzblau, S.G., Gut, J., Rosenthal, P.J. and Chibale,
faCUlTy of sCIeNCe
K. 2011. Novel thiolactone-isatin hybrids as potential
antimalarial and antitubercular agents. Bioorganic &
Medicinal Chemistry Letters, 21: 2055-2058.
Hunter, R., Msutu, A., Dwyer, C.L., Emslie, N.D., Hunt, R.C.,
Bezuidenhoudt, B.C.B. 2011. Facile one-pot synthesis of
carbamoylbenzotriazoles directly from CO 2 : synthesis of
tolbutamide. Synlett, 16: 2335-2338.
Idahosa, K.C., Lee, Y.-C., Nyoni, D., Kaye, P.T. and Caira,
M.R. 2011. Baylis-Hillman-derived N,N’-disubstituted
piperazines: structural and preliminary computational
studies. Tetrahedron Letters, 52: 2972-2976.
Kaschula, C.H., Hunter, R., Hassan, H.T., Stellenboom, N.,
Cotton, J., Zhai, x.Q. and Parker, M.I. 2011. Anti-proliferative
activity of synthetic ajoene analogues on cancer cell-lines.
Anti-Cancer Agents in Medicinal Chemistry, 11: 260-266.
Khanye, S.D., Gut, J., Rosenthal, P.J., Chibale, K. and Smith
G.S. 2011. Ferrocenylthiosemicarbazones conjugated to a
poly(propyleneimine) dendrimer scaffold: synthesis and
in vitro antimalarial activity. Journal of Organometallic
Chemistry, 696: 3296-3300.
Khanye, S.D., Wan, B., Franzblau, S.G., Gut, J., Rosenthal,
P.J., Smith, G.S. and Chibale, K. 2011. Synthesis and in
vitro antimalarial and antitubercular activity of gold(III)
complexes containing thiosemicarbazone ligands. Journal
of Organometallic Chemistry, 696: 3392-3396.
Kuter, D., Chibale, K. and Egan, T.J. 2011. Linear free
energy relationships predict coordination and π-stacking
interactions of small molecules with ferriprotoporphyrin Ix.
Journal of Inorganic Biochemistry, 105: 684-692.
Laferriere, C., Ravenscroft, N., Wilson, S., Combrink, J.,
Gordon, L. and Petre, J. 2011. Experimental design to
optimize an Haemophilus influenzae type b conjugate
vaccine made with hydrazide-derivatized tetanus toxoid.
Glycoconjugate Journal, 28: 463-472.
Li. J., Bourne, S.A. and Caira, M.R. 2011. New polymorphs
of isonicotinamide and nicotinamide. Chemical
Communications, 47: 1530-1532.
Li. J., Bourne, S.A., de Villiers, M.M., Crider, A.M. and
Caira, M.R. 2011. Polymorphism of the antitubercular
isoxyl. Crystal Growth & Design, 11: 4950-4957.
Mahajan, A., Kremer, L., Louw, S., Guéradel, Y., Chibale,
K. and Biot, C. 2011. Synthesis and in vitro antitubercular
activity of ferrocene-based hydrazones. Bioorganic &
Medicinal Chemistry Letters, 21: 2866-2868.
Makhubela, B.C.E., Jardine, A. and Smith, G.S. 2011. Pd
nanosized particles supported on chitosan and 6-deoxy-6amino
chitosan as recyclable catalysts for Suzuki-Miyaura
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