full report - UCT - Research Report 2011

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Cabrera, D.G., Douelle, F., Feng, T.-S., Nchinda, A.T.,
Younis, Y., White, K.L., Wu, Q., Ryan, E., Burrows, J.N.,
Waterson, D., Witty, M.J., Wittlin, S., Charman, S.A. and
Chibale, K. 2011. Novel orally active antimalarial thiazoles.
Journal of Medicinal Chemistry, 54: 7713-7719.
Caira, M.R., Georgescu, E., Georgescu, F., Albota, F.
and Dumitrascu, F. 2011. Contributions to syntheses of
pyrrolo[2,1-a]phthalazines. Monatshefte fur Chemie, 142:
743-748.
Caira, M.R., Dumitrascu, F., Georgescu, E., Georgescu, F.
and Popa, M.M. 2011. New pyrroles from quinazolinium
N1-ylides and acetylenic dipolarophiles. Revue Roumaine
de Chimie, 56(8): 771-776.
Caira, M.R., Georgescu, E., Barbu, L., Georgescu, F.
and Dumitrascu, F. 2011. New tri- and tetra-substituted
pyrroles via quinazolinium N1-ylides. Arkivoc, (x): 44-54.
Caira, M.R. 2011. Structural aspects of crystalline
derivatized cyclodextrins and their inclusion complexes.
Current Organic Chemistry, 15: 815-830.
Chellan, P., Chibale, K. and Smith, G.S. 2011. Molecular
structure of an unexpected binuclear salicylaldimine
semicarbazone palladium(II) complex. Journal of Chemical
Crystallography, 41: 747-750.
Chellan, P., Stringer, T., Shokar, A., Dornbush, P.J., Vazquez-
Anaya, G., Land, K.M., Chibale, K. and Smith, G.S. 2011.
Synthesis and in vitro evaluation of palladium(II) salicylaldiminato
thiosemicarbazone complexes against Trichomonas vaginalis.
Journal of Inorganic Biochemistry, 105: 1562-1568.
Chibale, K. and Guantai, E.M. 2011. Extracting molecular
information form African natural products to facilitate
unique African-led drug–discovery efforts. Future Medicinal
Chemistry, 3(3): 257-261.
Chilengi, R., Bashraheil, M. and Nzila, A. 2011. A phase
i trial to evaluate the safety and pharmacokinetics of lowdose
methotrexate as an anti-malarial drug in Kenyan
adult healthy volunteers. Malaria Journal, 10(63): 1-9.
Chiririwa, H. and Meijboom, R. 2011. (SP-4-2)-Chlorido{N-
[2-(diphenylphosphanyl)-benzylidene]benzylamine-2P,N}
(methyl)palladium(II). Acta Crystallographica Section
E-Structure Reports Online, E67: m1498.
Chiririwa, H., Moss, J.R., Su, H., Hendricks, D. and Meijboom,
R. 2011. 1,4-Bis[(2-pyridylethyl)iminomethyl]-benzene. Acta
Crystallographica Section E, 67:o921 (-o921 remove).
Chiririwa, H., Meijboom, R. and Omondi, B. 2011.
2 - ( T h i o p h e n - 2 - y l ) - N - ( 4 - { ( E ) - [ 2 - t h i o p h e n - 2 - y l )
ethyl]iminomethyl}benzylidene)ethanamine. Acta
Crystallographica Section E, 67:o922.
Chiririwa, H. and Meijboom, R. 2011. Dichlorido[2d
i p h e n y l p h o s p h a n y l - N - ( p y r i d i n - 3 - y l m e t h y l )
benzylidenamine-2P,N]platinum(II). Acta Crystallographica
Section E-Structure Reports Online, E67: m1497.
Chiririwa, H., Meijboom, R. and Omondi, B. 2011.
Dichlorido{N-[2-(diphenylphosphanyl)-benzylidene]
isopropylamine- ĸ 2N,P}palladium(II) dimethyl sulfoxide
monosolvate. Acta Crystallographica Section E,
67:m608-m609.
Chiririwa, H. and Meijboom, R. 2011. Dichlorido{N-
[ 2 - ( d i p h e n y l p h o s p h a n y l ) b e n z y l i d e n e ] - 2 , 6 -
diisopropylaniline-2 P,N}platinum(II). Acta Crystallographica
Section E-Structure Reports Online, E67: m1496.
Cruickshank, D.L., Bourne, S.A. and Caira, M.R. Solid-state
structures and thermal properties of inclusion complexes
of the phenylurea herbicide cycluron with permethylated
cyclodextrins. Arkivoc, (vii): 103-115.
Davidowitz, B. and Rollnick, M. 2011. What lies at the heart
of good undergraduate teaching? A case study in organic
chemistry. Chemistry Education Research and Practice,
12: 355-366.
De Villiers, M.M., Caira, M.R., Li, J., Strydom, S.J., Bourne,
S.A. and Liebenberg, W. 2011. Crystallization of toxic
glycol solvates of rifampin from glycerin and propylene
glycol contaminated with ethylene glycol or diethylene
glycol. Molecular Pharmaceutics, 8: 877-888.
D’hooghe, M., Kenis, S., Vervisch, K., Lategan, C., Smith,
P.J., Chibale, K. and De Kimpe, N. 2011. Synthesis
of 2-(aminomethyl)aziridines and their microwaveassisted
ring opening to 1,2,3-triaminopropanes as
novel antimalarial pharmacophores. European Journal of
Medicinal Chemistry, 46: 579-587.
D’hooghe, M., Vandekerckhove, S., Mollet, K., Vervisch,
K., Dekeukeleire, S., Lehoucq, L., Lategan, C., Smith,
P.J., Chibale, K. and De Kimpe, N. 2011. Synthesis of
2-amino-3-arylpropan-1-ols and 1-(2,3-diaminopropyl)-
1,2,3-triazoles and evaluation of their antimalarial activity.
Belstein Journal of Organic Chemistry, 7: 1745-1752.
Domingo, R., Chibale, K. and Sturrock, E.D. 2011. The
significance of the Cα substituent in the selective inhibition
of matrix metalloproteinases 1 and 9. Biological Chemistry,
392: 1003-1010.
Dubar, F., Egan, T.J., Pradines, B., Kuter, D., Ncokazi, K.K.,
Forge, D., Paul, J-F., Pierrot, C., Kalamou, H., Khalife, J.,
Buisine, E., Rogier, C., Vezin, H., Forfar, I., Slomianny,
C., Trivelli, x., Kapishnikov, S., Leiserowitz, L., Dive, D.
and Biot, C. 2011. The antimalarial ferroquine: role of the
metal and intramolecular hydrogen bond in activity and
resistance. ACS Chemical Biology, 6: 275-287.
UCT ReseaRCh RepoRT '11