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Chapter 2 21 F. Totsingan, T. Tedeschi, S. Sforza, R. Corradini, R. Marchelli, Chirality, 2009, 21, 245 22 E. A. Englund, D. H. Appella, Org. Lett., 2005, 7, 16, 3465 23 E. A. Englund, D. H. Appella, Angew. Chem. Int. Ed., 2007, 46, 1414 24 K. Petersena, U. Vogel, E. Rockenbauer et al., Molecular and Cellular Probes, 2004, 18, 117 25 F. Totsingan, S. Rossi, R. Corradini et al., Org. Biomol. Chem., 2008, 6, 1232 26 A Calabretta, Master Thesis,2006 54
Chapter 3 A new class of Chiral PNAs: Arginine PNAs This chapter presents a new class of modified PNAs: chiral arginine-based PNAs. The design and the synthesis of submonomers and monomers based on the structure of arginine are shown. The modified monomers have then used for the synthesis of a chiral PNA containing a 2D,5L-Arg monomer, to be compared with homologous probes based on lysine, and of a PNA containing three modified monomers (2D; 2D,5L; 5L).The scope is to explore the effect that modifications based on chiral positively charged amino acids have on PNA hybridization properties. The properties of these PNAs have been tested by measuring the melting temperatures of the corresponding PNA-DNA duplexes and comparing them with the previous generations of chiral PNAs. 55
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Università degli studi di Parma Do
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2.4.4 Fluorescence measurements ...
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Chapter 6 The double nature of Pept
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Preface In Chapter 2 a particular t
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Page 81 and 82: Arg-PNA Microarrays a surface. Alth
Page 83 and 84: Arg-PNA Microarrays 4.2 Results and
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Page 102 and 103: Chapter 5 Table 5-1. PNA sequences
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Chapter 5 times. The substrates wer
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Chapter 5 chemicals were used as re
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Chapter 5 5.4.6 Microcontact Printi
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Chapter 5 5.5 References 1 A. L. Be
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Chapter 6 6.1 Introduction The use
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Chapter 6 Among all the peptides us
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Chapter 6 Figure 6-2: A standard PN
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Chapter 6 peptide 1 and the PNA tri
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Chapter 6 6.2.2 Uptake experiments
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Chapter 6 (HBTU), N-[(dimethylamino
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Chapter 6 1.41 (s, 9H, Boc methyl g
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Chapter 6 Arg + CHα Lys), 4.0-4.6
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Chapter 6 12 B. P. Gangamani, V. A.
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Contributions Publications includin
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