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Chapter 3 3.5 References 1 R. Corradini, S. Sforza, T. Tedeschi, F. Totsingan, R. Marchelli, Current Topic in Medicinal Chemistry, 2007, 7, 681 2 F. Wojciechowski, H. E. Hudson, Current Topic in Medicinal Chemistry, 2007, 7, 667 3 R. Corradini, S. Sforza, T. Tedeschi, R. Marchelli, Chirality, 2007, 19, 269 4 A. Puschl, S. Sforza, G. Haaima, O. Dahl, P. E. Nielsen, Tetrahedron Lett., 1998, 39, 4707 5 P. Wittung, M. Eriksson, R. Lyng, P. E. Nielsen, B. Norden, J. Am. Chem. Soc., 1995, 117, 10167 6 G. Haaima, A. Lohse, O. Buchardt, P. E. Nielsen, Angew.Chem. Int. Ed., 1996, 35, 17, 1939 7 E. A. Englund, D. H. Appella, Angew. Chem. Int. Ed., 2007, 46, 1414 8 S. Sforza, G. Haaima, R. Marchelli, P. E. Nielsen, Eur. J. Org. Chem., 1999, 197 9 T. Tedeschi, S. Sforza, R. Corradini, R. Marchelli, Tetrahedron Letters, 2005, 46, 48, 8395 10 S. Sforza, R. Corradini, S. Ghirardi, A. Dossena,R. Marchelli, Eur. J. Org. Chem., 2000, 2905 11 V. Menchise, G. De Simone, T. Tedeschi, PNAS, 2003, 100, 21, 12021 12 T. Tedeschi, M. Chiari, G. Galaverna, S. Sforza, M. Cretich, R. Corradini, R. Marchelli, Electophoresis, 2005, 26, 22, 4310 13 S. Sforza, T. Tedeschi, R. Corradini, A. Dossena, R. Marchelli, Chemical Communications, 2003, 9, 1102 14 J. Weiler, H. Gausepohl, N. Hauser, O. N. Jensen, J. D. Hoheisel, Nucleic Acids Research, 1997, 25, 14, 2792 15 S. Sforza, T. Tedeschi, R. Corradini, D. Ciavardelli, A. Dossena, R. Marchelli, Eur. J. Org. Chem., 2003, 6, 1056 16 S. Sforza, T. Tedeschi, R. Corradini, R. Marchelli, Eur. J. Org. Chem., 2007, 5879 17 T. Tedeschi, S. Sforza, R. Corradini, R. Marchelli, Tetrahedron Lett., 2005, 46, 8395 18 S.A. Thomson, J.A. Josey, R. Cadilla, M.D. Gaul, C.F. Hassman, M.J. Luzzio, A.J. Pipe, K.I. Reed, D.J. Ricca, R.W. Wiethe, S.A. Noble, Tetrahedron, 1995, 51, 6179 72
Chapter 4 Chiral PNA application on surface: Arginine-based PNA microarrays for ApoE genotyping In this chapter PNAs containing a 2D-5L arginine monomer are utilized in diagnostic applications on surface. The design and synthesis of the modified PNAs by submonomeric strategy are described. The probes have been designed targeting sequences contained in the human gene coding for ApoE (a protein related to the cholesterol metabolism), in order to recognize six different genotypes corresponding to SNPs present in two different positions and related to the risk of the Alzheimer disease onset. After the synthesis, an innovative application is described, consisting in the fabrication of microarrays bearing chiral PNAs for a fast and precise genotype characterization. 73
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Università degli studi di Parma Do
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2.4.4 Fluorescence measurements ...
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Chapter 6 The double nature of Pept
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Preface In Chapter 2 a particular t
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Chapter 1 PNAs: From birth to adult
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PNAs: from birth to adulthood one,
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PNAs: from birth to adulthood betwe
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PNAs: from birth to adulthood explo
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PNAs: from birth to adulthood well,
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PNAs: from birth to adulthood + Res
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PNAs: from birth to adulthood repet
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PNAs: from birth to adulthood 1.6 M
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Chapter 6 (HBTU), N-[(dimethylamino
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Chapter 6 1.41 (s, 9H, Boc methyl g
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Chapter 6 Arg + CHα Lys), 4.0-4.6
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Chapter 6 12 B. P. Gangamani, V. A.
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Contributions Publications includin
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