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Universlty of Manitoba, ln Partîal Fulfiìlment - MSpace at the ...

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4.8 H ISTOLOûI CAL EXAMINATION<br />

4.8.<br />

1<br />

Ser ia l Sectloning<br />

4.8.2 Group ing <strong>of</strong> Embryos<br />

4.8.3 Subd ivi s ion ¡nro Regions<br />

4.8.4 Histo¡ogical Descriptions<br />

\.9 ANALYSIS oF NEURAL CLOSURE<br />

4.lo Rruelysts oF NEURAL voLuMEs<br />

RESULTS OF TERATOLOGICAL PROCEDURES<br />

5.1 TERATOGENIC EFFECT OF t.,INDOWING<br />

5.2 HALFOR}IATIONS PRODUCED BY I,'INDOWING<br />

5.3 INVEST¡GATION OF EFFECT OF WINDOI^'ING<br />

5.3.1 Vibr<strong>at</strong>îon <strong>of</strong> Unopened Eggs<br />

5.3,2 Parafi lm and Plasticine Alone<br />

5.3.3 0bl iter<strong>at</strong>ion <strong>of</strong> <strong>ln</strong>troduced Air Space . . .<br />

5.\ BACTERIOLOGICAL CULTURE<br />

RESULTS OF EMBRYOLOGICAL STUDIES<br />

6.1 EI"IBRYoGENESIS oF OPEN NEURAL DEFECTS<br />

L-l<br />

47<br />

47<br />

4B<br />

5\<br />

54<br />

55<br />

56<br />

57<br />

65<br />

69<br />

69<br />

'72<br />

75<br />

92<br />

95<br />

96<br />

6.1.1 Embryoníc Sízes <strong>at</strong> 26 Hours<br />

6.1.2 Mortal i ty wi th Varying periods<br />

<strong>of</strong> <strong>ln</strong>cub<strong>at</strong>ion after l/ïndowing -102<br />

6.1.3 Neural Closure and Neural Defects lO9<br />

6.1.4 Development <strong>of</strong> open Neural Defects ll4<br />

6.1.5 Dlstribution <strong>of</strong> 0pen Cord Defects 144<br />

6.2 SPINAL LEVELS OF oPEN CORD DEFECTS IN 12-DAY E}4BRYos 154<br />

6.3 DESCRIPTIoN oF HISTOI.OGIcAL APPEARANCES 165<br />

6.3.1 Stage l0 controt Embryos 165<br />

96

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