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Universlty of Manitoba, ln Partîal Fulfiìlment - MSpace at the ...

Universlty of Manitoba, ln Partîal Fulfiìlment - MSpace at the ...

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187<br />

overl îes three accessory canals <strong>at</strong> <strong>the</strong> rhomboid sinus. Establ ished myeloschlsls<br />

(42E 8,f 19. 99) is assocî<strong>at</strong>ed with eversion <strong>of</strong> neural m<strong>at</strong>erîal<br />

<strong>at</strong> <strong>the</strong> upper and lower ends <strong>of</strong> <strong>the</strong> leslon, separ<strong>at</strong>¡on <strong>of</strong> neural sources<br />

wîth progresslve reduction <strong>of</strong> neural pl<strong>at</strong>e m<strong>at</strong>erlal, and separ<strong>at</strong>ion <strong>of</strong><br />

notochord from neural tÌssue <strong>at</strong> <strong>the</strong> cranial end <strong>of</strong> tbe leslon.<br />

<strong>ln</strong> hemlmyel¡a (30E 76 ,428 50,Fl9s. lot s 102)<strong>the</strong> open defecrs extend<br />

cranlally up from <strong>the</strong> ta¡l bud; <strong>the</strong>re is no sign <strong>of</strong> an overlap zone<br />

comparable to <strong>the</strong> control embryo (3OC ZZ,flg.100 ) showing accessory<br />

canals and a fully closed neural pl<strong>at</strong>e. The cross-sectlonal area <strong>of</strong><br />

':<br />

neural tîssue is reduced <strong>ln</strong> hemìmyel la and <strong>the</strong>re is no separ<strong>at</strong>ion<br />

<strong>of</strong> neural tissue from notochord.

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