Presidential Greeting - American Society for Laser Medicine and ...

subjects improved, while the majority of control subject showed no
change over the trial period (P < 0.01). Patients’ satisfaction with
treatment was high. IUS therapy was generally well tolerated
with no unusual adverse effects observed. The most common
adverse reactions included transitory mild erythema, oedema,
and parasthesia.
Conclusion: IUS exposure appears to be safe and effective to
treat skin laxity of the lower face. The novel 3D laser scanner is a
promising method for quantitative measurements of the lower face
following IUS treatment. Further trials to advance therapeutic
applications of this innovative approach are warranted.
#72
A NOVEL METHOD FOR OBJECTIVELY
ASSESSING LIPOSUCTION OUTCOMES:
3-DIMENSIONAL SURFACE IMAGING
Elliot Weiss, Lori Brightman, Roy Geronemus
Laser & Skin Surgery Center of New York, New York, NY
Background: Although the field of body contouring is evolving
rapidly, quantitative methods of evaluating treatment outcomes
are lacking. Outcomes are often evaluated with qualitative
photographic comparisons and tape measure changes in
circumference. These techniques introduce human error and do
not allow measurement of 3-dimensional (3D) changes in body
shape. 3D photography enables precise circumference, skin
tightening, and volumetric measurements to be performed on preand
post-treatment 3D images. We present the first series of
abdominal liposuction outcomes quantitatively evaluated using a
3D photographic imaging system.
Study: Five female subjects underwent abdominal laser-assistedliposuction
procedures, and baseline and follow-up (average 11
weeks) 3D photographic images were obtained for each treatment
area. Corresponding baseline and follow-up image were aligned
using surface landmarks, and quantitative measurements of
circumference, surface contour, and volume change were
performed.
Results: In all treated subjects, 3D photography detected
decreases in abdominal circumference, surface contour, and
volume post-liposuction. For abdominal circumference, the
average reduction at follow-up was 2.26 cm. For each abdominal
treatment area, average volume reduction at follow-up was 213 cc.
3D imaging detected surface contour changes in all subjects
corresponding to the liposuction treated areas.
Conclusion: 3D photography allows investigators to reliably
detect and quantify minute changes in body shape. Using a 3D
photographic imaging system, we have demonstrated the ability
to reproducibly quantify circumference, surface contour, and
abdominal volume changes post-abdominal liposuction. 3D
imaging provides superior objective assessments of liposuction
treatment outcomes.
#73
American Society for Laser Medicine and Surgery Abstracts 23
HIGH-INTENSITY FOCUSED ULTRASOUND
DEVICE FOR NON-INVASIVE BODY
CONTOURING: AGREEMENT OF OBJECTIVE AND
SUBJECTIVE AESTHETIC OUTCOMES
Jeffrey Dover, Patrick Martin, Ira Lawrence,
The Sculpt Group
Skin Care Physicians, Chestnut Hill, MA; Medicis Technologies
Corporation, Scottsdale, AZ
Background: In clinical practice, body contouring must achieve
subjective aesthetic improvement, but clinical trials require
objective data for analysis. In a randomized controlled trial,
noninvasive high-intensity focused ultrasound (HIFU) was
evaluated using change from baseline waist circumference
(CBWC) as an objective surrogate marker of aesthetic
outcome. This post hoc analysis compared CBWC with
subjective investigator and patient assessments of aesthetic
improvement.
Study: One hundred eighty adults (mean [SD] age, 42 (11) years)
with abdominal subcutaneous fat ¼ 2.5 cm thick and body mass
index < 30 kg/m 2 were randomized to HIFU of the anterior
abdomen and flanks at energy levels (each of 3 passes total) of 47
(141 total), 59 (177 total), or 0 (sham) J/cm 2 . CBWC at the level of
the iliac crest was assessed at week 12 using validated assessment
tools. Subjective endpoints included investigator-assessed Global
Aesthetic Improvement Scale and a patient satisfaction survey at
week 12.
Results: After 12 weeks, least square mean CBWC was
statistically significantly superior with 59-J/cm 2 treatment
( 2.44 cm, P ¼ 0.01) and showed a nonsignificant trend toward
greater CBWC with 47-J/cm 2 treatment ( 2.06 cm, P ¼ 0.13)
compared with sham ( 1.43 cm). The proportion of patients rated
by investigators as improved/very much improved was
significantly higher with 59-J/cm 2 (78.3%) and 47-J/cm 2 (72.4%)
treatments compared with sham (15.5%). Similarly, the
proportion of patients rating their abdomen as improved/very
much improved was greater with 59-J/cm 2 (68.3%) and 47-J/cm 2
(55.2%) treatments compared with sham (24.1%; P < 0.001 for
each comparison). Adverse events (AEs) included procedural/
postprocedural discomfort, bruising, and edema. No serious AEs
were reported.
Conclusion: Objective CBWC results and subjective
physician and patient assessments each indicated that
active HIFU treatments were superior to sham for reduction of
waist circumference, suggesting that CBWC is a reliable
surrogate marker of overall aesthetic outcome for body
contouring.
#74
MELANIN OPTICAL DENSITY AS A PREDICTOR
OF MAXIMUM TOLERATED FLUENCE FOR
PHOTODERMATOLOGY
Ilya Yaroslavsky, Gregory Altshuler,
Guangming Wang, Felicia Whitney, Henry Zenzie
Palomar Medical Technologies, Inc., Burlington, MA
Background: Fitzpatrick skin typing (FST) is the standard
method used to predict maximum tolerated fluence for
photothermal treatments with visible/near-IR light. FST assesses
skin response to UV; however, for visible/near-IR wavelengths,
melanin optical density (MOD) is more appropriate as a predictor
of maximum tolerated fluence. The goal of this work was to find a
correlation between maximum tolerated fluence and MOD. We
present a retrospective analysis of data from five clinical studies.
Study: Maximum tolerated fluence was measured on over 150
patients in five clinical studies with different 800 nm pulsed lasers
and an intense pulsed light source with wavelengths from 400–
1,200 nm, 500–1,200 m, 500–650/850–1,200 nm, and 600–
1,200 nm. Testing was conducted on the face, thigh, bikini line,
axilla, and back. FST was conducted by using a standard patient
questionnaire, and MOD was measured in the test area by using a
dual-wavelength backscattering reflectometer. Maximum