Presidential Greeting - American Society for Laser Medicine and ...

etween two groups for MI after treatment(s) (P ¼ 0.030).
Spearman correlation analyses of skin color parameters in
combined treatment group revealed significant positive
relationship between MI after IPL and MI after both treatments
(R ¼ 0.694), and EI after IPL and EI after both treatments
(R ¼ 0.544). Clinical improvement was evaluated as modified
MASI score. Modified MASI score reduction were 65.31% and
43.92% in group A and B, respectively. In terms of safety, no
serious adverse events occurred in the treatment period for both
groups.
Conclusion: IPL and successive subthreshold level of laser
exposures may provide more rapid clinical resolution than laser
irradiation alone in mixed type melasma.
#234
LASER THERAPY FOR THE TREATMENT OF
NECK PAIN: A CLINICAL STUDY
Renato Liboro, Fred Kahn, Fernanda Saraga
Meditech International, Inc., Toronto, Canada
Background: In most statistics presented, neck pain is
commonly lumped together with low back pain as a presenting
chief complaint that experts believe 85% of the North American
adult population will experience at one point in their lives.
However, when literature is concerned, a huge amount of peerreviewed
articles have been devoted solely on neck pain as it is a
common and burdensome problem, and according to Workplace
Safety and Insurance Board, an underrated but significant cause
of loss of productive work hours. Many studies have been done to
determine which among the most commonly prescribed neck pain
treatments such as non-steroidal anti-inflammatory drugs
(NSAIDS), exercise and manual therapies was the best choice, yet
no option has ever been clearly deemed superior. The introduction
of Low-Intensity Laser Therapy as another therapeutic modality
for successfully treating neck pain and improving the quality of
life of long-term neck pain sufferers has gained significant
interest in the last decade.
Study: In a follow-up clinical study to our previously
published 2006 SPIE conference proceeding, we analyzed
a cross-section of patients treated for a variety of neck pain
problems that present at our Meditech Laser Rehabilitation
Clinics on a daily basis including age and gender distribution, type
of pathology, number of treatments and percent of overall
improvement.
Results: Of the 101 patients with neck pain pathologies included
in this study, 49% presented with degenerative osteoarthritis. On
average 10 treatments, each 30–45 minutes in duration, were
administered for the individual patient resulting in a significant
improvement rate averaging 94.5%.
Conclusion: Laser therapy is active at both the cellular and
systemic levels activating a variety of mechanisms including DNA
synthesis, improved microcirculation, cartilage regeneration, and
an analgesic and anti-inflammatory effect.
#235
American Society for Laser Medicine and Surgery Abstracts 69
SELF-ADAPTIVE EFFECTS OF LOW INTENSITY
LASER IRRADIATION IN PROPHYLAXIS OF
MUSCULAR FIBROSIS
Timon Cheng-Yi Liu, Li Luo, Lin Zhang
School of Sports Science, Soochow University, Suzhou, China;
Laboratory of Laser Sports Medicine, South China Normal
University, Guangzhou, China
Background: Fibrosis is one of the largest groups of diseases, but
there is no effective therapy. Fibrosis may be resulted from many
dysfunctions which might be modulated with low intensity
gallium aluminum arsenide 635 nm laser irradiation (LIGL) in
this paper.
Study: Ninety-six male Sprague–Dawley rats were randomly
divided into three groups: control, contusion and LIGL groups.
LIGL at 17.5 mW/cm 2 was administered to the gastrocnemius
contusion for 30 min each time once a day 10 days. The
histological examination and biochemical assessment were done
for 4 weeks.
Results: LIGL increased the numbers of regenerating myofibers
(P < 0.01) on the 7th and 14th day, but decreased the ones
(P < 0.05) on the 21st and 28th day, and increased the diameters
of regenerating myofibers (P < 0.05) but decreased the fibrotic
area in the injured muscles (P < 0.01) on 14th, 21st and 28th day,
respectively. LIGL decreased muscular malondialdehyde (MDA)
(P < 0.01) and promoted muscular superoxide dismutase activity
(P < 0.05) on the 1st, 2nd and 3rd day, respectively, and
decreased MDA on the 7th day (P < 0.05). LIGL promoted
(P < 0.05) insulin-like growth factor-1 (IGF-1) mRNA expression
on the 1st, 2nd, 3rd and 7th day, but inhibited (P < 0.01) the one
on the 14th and 21st day, respectively. LIGL increased (P < 0.05)
IGF-1 level on the 2nd, 3rd and 7th day, but decreased (P < 0.01)
the one on the 14th and 21st day, respectively. LIGL decreased
(P < 0.05) transforming growth factor (TGF)-beta1 level on the
3rd and 28th day, but increased (P < 0.05) the one on the 7th and
14th day, respectively.
Conclusion: LIGL inhibited fibrosis by promoting the
regeneration of muscle. The LIGL effects on IGF-1, TGF-beta1
and oxidative stress might be self-adaptive. *It was supported by
NSFC.
#236
GUIDING PROSTATE CANCER PDT/LITT
THERAPIES USING AUTOMATIC WARPING OF
MRI-BASED PLANNING DATA
Nasr Makni, Philippe Puech, Feras Marqa,
Serge Mordon, Nacim Betrouni
Inserm U703; CHU, Lille, France
Background: In the last decade, new prostate cancer treatment
options have been developed thanks to the advances in laser
ablation techniques. PDT and LITT are currently being
experimented in order to ablate index lesions while minimizing
treatment morbidity. In these modalities, fibres’ positions
planning and light dose simulations are usually performed on
MRI, while transrectal ultrasound is used to guide the treatment.
Physicians have then to mentally register planning data to realtime
ultrasound, which induces time waste, imprecision and interoperator
variability. In order to optimise this process, we
introduce a method for automatic registration of PDT/LITT
planning data from MRI to ultrasound.
Study: The method is a geometric feature registration based on
the Robust Point Matching algorithm, proposed by Chui and
Rangarajan (2003), combined with the Thin Plate Spline non rigid
transformation. An optimal warping is computed based on
landmarks initialization as performed by an expert, and fibres’
positioning is then optimised and displayed on ultrasound images,
with respect to the brachytherapy frame. We test and evaluate our