Presidential Greeting - American Society for Laser Medicine and ...

Results: Average treatment times for the deep and superficial
treatments were 3.1 and 3.6 minutes, respectively. No serious
adverse events occurred. Seventy-five percent of subjects
demonstrated improvement in upper eyelid hooding at the 6month
follow-up visit using a novel grading scale. This scale will
be presented and discussed. Eyelid skin wrinkling improved in
70% of subjects. Improvement in lower lid appearance was noted
in 80% of subjects at the 6-month follow-up. Sixty percent of
subjects demonstrated improvement in the appearance of crow’s
feet lines at 6 months. Change from baseline in other endpoints
was more variable.
Conclusion: Ablative fractional resurfacing can produce
dramatic improvement in eyelid appearance. Some characteristics
predispose favorable outcomes.
#96
COLD INDUCED MODULATION OF TARGETED
FACIAL NERVES. A PILOT STUDY OF A
MINIMALLY INVASIVE CRYOPROBE DEVICE FOR
IMMEDIATE REDUCTION OF DYNAMIC
WRINKLES
Vic Narurkar, Francis Palmer, Thomas Munyon,
Kristine Tatsutani
Los Angeles, CA; California Pacific Medical Center,
San Francisco, CA; Munyon Dermatology; Myoscience,
Redwood City, CA
Background: Reduction of dynamic lines using neurotoxins is
the most demanded procedure in the United States. The study
objective was to evaluate a minimally invasive cryoprobe device
that targets motor nerves to achieve immediate reduction of
dynamic wrinkles without the use of a neurotoxin.
Study: In a cohort of 31 subjects a 27 gauge cryoprobe was
inserted subcutaneously near the temporal branch of the facial
nerve that innervates the frontalis muscle. After administering
each cooling cycle of less than 60 seconds, the investigator
monitored reduction in muscle contractility to determine if
additional cryoprobe insertions were needed to achieve the
desired cosmetic effect.
Results: One hundred percent of subjects experienced immediate
dynamic line reduction after two to eight cryoprobe insertions
near the motor nerves that power the frontalis muscle. The most
frequent observed side effects were headaches and small focal
areas of minor epidermal cold injury. Efficacy was sustained
through subsequent follow-up visits.
Conclusion: Cold induced neuromodulation using a minimally
invasive cryoprobe results in immediate and sustained reduction
of dynamic lines of the frontalis by targeting the associated facial
nerve. Immediate endpoint observation allows optimization of the
effect for facial muscle groups.
#97
American Society for Laser Medicine and Surgery Abstracts 31
ENHANCED SKIN REJUVENATION: A NOVEL
COMBINED NON-ABLATIVE AND FRACTIONAL
APPROACH
Hanit Brenner-Lavie, Yossi Adanny,
Avner Rozenberg, Haim Epstein, Genady Nahshon,
Ruthie Amir, Ulrich Toft, Tal Nachlieli,
Boris Vaynberg
Syneron Medical, Ltd, Yokneam Illit, Israel; Assuta Medical
Center, Haifa, Israel
Background: Ablative devices provide high efficacy but with
prolonged recovery times, whereas non-ablative devices have
shortened recovery periods but offer modest efficacy. Fractional
devices have shorter downtime and fewer adverse effects than
ablative devices and greater efficacy than non-ablative devices.
Combining non-ablative and fractional treatment can offer higher
efficacy than achieved by each procedure alone.
Study: We used physical modeling to describe temperature
distribution in the skin induced by the application of combined
broadband IR light and bipolar RF. Histology of human facial skin
under the impact of sublative RF evaluated in vivo the biological
tissue effects. A biological model for the combined application
mechanism of action has been developed.
Results: Based on biophysical modeling, combined broadband IR
light and bipolar RF applied simultaneously with cooling of the
skin surface creates reticular dermal tissue islands reaching
> 50–558C, surrounded by deep volumetric heating of the entire
dermis (45–508C) with complete sparing of the epidermis. In vivo
analysis of fractional sublative RF demonstrates epidermal tissue
ablation up to 150 mm depth beyond which the papillary dermis is
affected mainly by coagulation (up to 150 mm deeper and
occasionally lateral). A biological model for the combined
application will be presented.
Conclusion: The underlying mechanism of action of this unique
combination is the synergistic induction of local healing response
leading to modification of connective tissue via collagen
remodeling. With sublative RF, tissue injury leads to
inflammatory reaction and the responsive healing process
involves ECM remodeling of the upper dermis. Conversely, deep
volumetric heating by the non-ablative application causes
immediate tissue tightening due to collagen denaturation and
collagen contraction followed by a delayed healing response of the
deep dermis. Ongoing clinical studies suggest that this novel
approach promotes the desired biological responses leading to a
more and better organized younger dermal matrix.
#98
LONG-TERM EFFICACY AND SAFETY OF MICRO-
FOCUSED ULTRASOUND FOR SKIN TIGHTENING
AND LIFTING: RESULTS IN 183 KOREAN
SUBJECTS
Nark-Kyoung Rho, Chan-Woo Jeong, Deuk-Pyo Lee,
Sangjin Park, Seung-Hui Kang, Jang-Hyun Shin,
Byung-Soon Park
Leaders Aesthetic Laser & Cosmetic Surgery Center, Seoul, Korea
Background: The objective of this study was to evaluate the longterm
safety and efficacy of a micro-focused ultrasound treatment for
non-invasive skin tightening and lifting in Korean patients.
Study: A total of 183 Korean subjects ranging in age from 25 to 76
received a full face treatment utilizing the micro-focused
ultrasound therapeutic system. For upper third of the face, only
the 3.0 mm-depth transducer was used while two transducers
(3.0 mm, 4.5 mm) were used in combination for the treatment of
mid- and lower face. Photographs taken at 1 month, 3 months, 6
months, and 9 months following treatment were evaluated by two
independent dermatologists not involved in the treatment.
Clinical improvement was also assessed subjectively. Any adverse
events and patient discomfort was also recorded.
Results: Overall, the percentage of subjects responding with an
improvement was 82% at 1 month, 87% at 3 months, 79% at 6
months, and 65% at 9 months following treatment. Objective
assessment at 3 months showed significant improvement for