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30 American Society for Laser Medicine and Surgery Abstracts
follow-up; 1.50 at the 3-month follow-up; and 2.00 at the 6-month
follow-up. Average pain reported over all treatments was 4.5.
Moderate erythema and mild edema were post-treatment responses.
Therewerenoincidencesofscarringorpost-inflammatory hyper- or
hypopigmentation throughout the course of this study.
Conclusion: Non-ablative fractional resurfacing with the
1,927 nm thulium fiber laser is a safe and effective treatment
modality for melasma on the face.
#93
EFFICACY OF 1,927 NM THULIUM FIBER LASER
FOR THE TREATMENT OF MELASMA IN CHINESE
PATIENTS
Samantha Y. Shek, C.K. Yeung, Stephanie G.Y. Ho,
Henry H.L. Chan
The University of Hong Kong, Hong Kong, China
Background: 1,927 nm thulium fiber laser contains two fiber
lasers in one system. It is FDA approved for non-ablative skin
resurfacing and rejuvenation. The objective of the study is to
assess the efficacy of 1,927 nm thulium fiber laser for the
treatment of melasma in Chinese patients. It provides a higher
wavelength with higher absorption.
Study: Twelve female subjects aged 44–58 with mild to severe
melasma were recruited. All subjects received a single treatment.
They were assessed at baseline, 1 day, 7 days, 1 month and 2
months post-treatment. Adverse effects were noted and clinical
photos were taken using (Canfield Visia CR System). A
questionnaire was given at the follow-ups for the subjects to rate
the pain level, swelling, dryness, wrinkles, pore size,
pigmentation, any hyper/hypopigmentation as well as overall
satisfaction. Two independent physicians assessed the clinical
photos, giving the MASI score, rating the skin texture and
identifying any adverse effects.
Results: All subjects experienced pain and swelling, all of which
subsided within 7 days post-treatment. 54.5% and 58.3% subjects
noticed an improvement in their melasma at 1 and 2 months posttreatment,
respectively. A decrease in wrinkles was observed by
36.4% at 1-month post-treatment but the effect only lasted in
16.7% by 2 months post-treatment. Sixty-two percent noticed an
improvement in pore size. Physician assessment supported the
above with a statistically significant improvement in MASI score
(P ¼ 0.018), pore size (P ¼ 0.011) and skin texture (P ¼ 0.005).
The improvement in fine lines was also significant at 1-month
follow-up (P ¼ 0.014) but was not enough to be statistically
significant at 2 months follow-up.
Conclusion: 1,927 nm thulium fiber laser is temporarily effective
for treating melasma in Chinese patients. The treatment also
improves the overall skin texture.
#94
NON-ABLATIVE 1,550 NM FRACTIONAL LASER
THERAPY NOT EFFECTIVE FOR ASHY
DERMATOSIS AND POSTINFLAMMATORY
HYPERPIGMENTATION: A PILOT STUDY
Bas Wind, Marije W. Kroon, Bas S. Wind,
Arne A. Meesters, Albert Wolkerstorfer,
J.P. Wietze Van der Veen, Jan D. Bos,
Allard A. Van der Wal, Johan F. Beek
The Netherlands Institute for Pigment Disorders Amsterdam,
The Netherlands
Background: Ashy dermatosis, also known as erythema
dyschromicum perstans, is an acquired benign disease,
characterized by blue-gray pigment patches with erythematous
borders. No effective treatment is available. Postinflammatory
hyperpigmentation is a pigment disorder resulting after
inflammation of the skin due to various causes. Existing
treatments often show disappointing effects. The aim of this study
was to assess the efficacy and safety of non-ablative 1,550 nm
fractional laser therapy (FLT) in the treatment of
postinflammatory hyperpigmentation and ashy dermatosis.
Study: Eight patients with ashy dermatosis (skin type IV–V) and
six patients with postinflammatory hyperpigmentation (skin type
II–V) were included in a randomized controlled, observer blinded
trial. In each patient, two similar square test regions of 5–10 cm 2
were randomized to receive either five non-ablative FLT
treatments (?: 1,550 nm, 15 mJ/microbeam, final coverage: 14–
17%; 3 weeks inter-treatment interval) in combination with
intermittent daily topical bleaching (to prevent laser-induced
postinflammatory hyperpigmentation) or the same intermittent
regimen of topical bleaching alone (to allow comparison of the
regions). Three months after the last treatment clearance of
hyperpigmentation was assessed by melanin index, reflectance
spectroscopy, physician’s global assessment, patient’s global
assessment and patient’s satisfaction. In addition, a biopsy of both
treated and control site was evaluated by an independent blinded
pathologist.
Results: Three months after the last laser treatment, no clinical
improvement of hyperpigmentation was observed. Reflectance
spectroscopy, melanin index, number of melanocytes and amount
of dermal melanin did not significantly differ between both
regions. Patient’s global assessment and patient’s satisfaction
were both 3.6 and 5.7, and 4.5 and 4.5, respectively (visual
analogue scale 0–10). Moreover, three patients developed laserinduced
postinflammatory hyperpigmentation.
Conclusion: With these laser settings, non-ablative FLT was not
effective for the treatment of ashy dermatosis and
postinflammatory hyperpigmentation.
#95
ABLATIVE FRACTIONAL RESURFACING OF
EYELIDS: A PROSPECTIVE EVALUATION
Brian Biesman
Nashville Centre for Laser and Facial Surgery, Nashville, TN
Background: Ablative fractional resurfacing of the eyelids has
been previously described. These reports are few and have not
evaluated many of the factors important to eyelid aesthetics. The
goal of this study was to evaluate the outcomes of eyelids treated
via ablative fractional techniques.
Study: This was a single site, prospective study in which 20
subjects underwent fractional ablative resurfacing using a carbon
dioxide (CO2) laser (Lumenis, Inc., Santa Clara, CA). The laser
was used in two separate modes, one in which small (120 m) spots
were used to create deep injury and another in which larger
(1.3 mm) spots were used to treat more superficially. Energies
used with the small spot ranged from 12.5 to 20 mJ and with the
larger spot ranged from 80 to 100 mJ. All treatments were
performed under topical anesthesia only. Follow-up was at 1
week, 2 weeks, 3 months, and 6 months. Subjects were assessed
for skin wrinkling, color, roughness, erythrosis and texture, upper
eyelid hooding, lower eyelid appearance, and crow’s feet
appearance. Professional photographs were taken at baseline,
3 months, and 6 months after treatment.