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70 American Society for Laser Medicine and Surgery Abstracts
#238
algorithm using physical phantom, which enables comparison to
real ground truth. Patients’ data, with expert interpretation, are
also used in these evaluations while taking into account the interobserver
variability.
Results: Preliminary results showed that the method is
satisfyingly accurate, as Target Localization Errors were of
1.92 0.14 mm and 1.85 0.26 mm for phantom and patients’
data, respectively. This performance was not correlated neither to
the number of landmarks nor to the expert who defines them.
Conclusion: As a part of a Treatment Planning System for
prostate cancer PDT and LITT, our method can bring significant
improvement in fibres’ positioning accuracy, and hence contribute
in increasing laser therapies precision. Application of this method
to breast cancer LITT is currently being investigated.
#237
THE ADIPOCYTE AS AN ENDOCRINE ORGAN?
A SYSTEMATIC REVIEW OF RECENT
LITERATURE ELUCIDATING THE
FUNCTIONALITY OF ADIPOCYTES
Jillian Maloney, Ryan Maloney, Steven Shanks
Erchonia, McKinney, TX; University of Arizona, Gilbert, AZ
Background: Invasive or non-invasive strategies for body
slimming represent the most frequently performed cosmetic
procedure in the United States. The therapeutic target has
remained unchanged for decades, which is the adipocyte. Studies
indicate that adipose tissue is responsible for the synthesis of
bioactive peptides and hormones participating in autocrine,
paracrine, and endocrine communication pathways. Emerging
functionality has established the adipocyte as an endocrine organ
and has raised new questions regarding the overall health benefit
of cosmetic slimming procedures.
Study: A standard literature review was performed using the
following keywords ‘‘adipocyte,’’ ‘‘adipokines,’’ ‘‘endocrine organ,’’
‘‘leptin,’’ ‘‘adiponectin,’’ ‘‘visfastin,’’ ‘‘resistin,’’ and ‘‘proinflammatory
cytokines.’’ The evidence-based medicine (EBM)
search engine at the University of Arizona Health Sciences
Library was used. The EBM search engine is an adopted version of
the Oxford Center for Evidence-Based Medicine Levels of
Evidence. No standard inclusion or exclusion process was
established for the articles used in the review process.
Results: Studies have revealed gene expression of a diverse
collection of peptides, hormones, and cytokines that are
synthesized by adipocytes which are commonly referred to as
‘‘adipokines.’’ Adipocyte-derived bioactive substances are
correlated with numerous metabolic disorders and play a pivotal
role in the prevention of cardiovascular disease and diabetes.
Adipokines are linked with lipid metabolism and homeostasis,
energy consumption and expenditure, immunity, insulin
sensitivity, and blood pressure. In a lean mass state adipocytes
synthesize a unique arrangement of adipokines; conversely,
hypertrophic adipocytes become impaired and begin to secrete
deleterious bioactive substances promoting obesity-related
comorbidities.
Conclusion: Increased adipose mass is strongly correlated with
obesity-related diseases, but adipocyte reduction as observed in
lipoatrophic patients possesses severe metabolic consequences.
Adipose tissue in recent years has displayed endocrine organ
characteristics central to the dynamic control of energy
metabolism and insulin sensitivity, and cosmetic strategies
aimed at adipocyte destruction may possess noxious metabolic
effects.
THE NEW FASHION VECTORIAL WAY TO
IMPROVE FAT REMODELING AND SCULPTING
THE FACE USING NON-INVASIVE IN MOTION
SELECTIVE SHEAR WAVES ULTRASOUND
(ACCENT ULTRA)
Elaine Marques, Guilherme Almeida,
Leticia Almeida, Rachel Queiroz
Hospital Sirio Libanes, Sao Paulo, Brazil
Background: The demand for a nonsurgical, noninvasive
treatment of located fat has inspired some manufactures to invest
in a new age of sophisticated devices and treatment therapies to
repair the skin and improve contours. The aim of this paper is to
present a new vectorial fashion way to improve of fat remodeling
and sculping the face using the combination of non invasive in
motion selective ultrasound (ACCENT ULTRA, Alma Lasers).
Study: Forty-two patients with located fat on the submental and
malar were treated (age 18–76). The sessions with Ultra were
separated by 14 days apart in a total of three treatments using the
same parameters of 8 minutes (cool waves) and level 3 (hot waves)
on submental and 4 minutes and level 5 each malar part. Results
were evaluated by standard and three-dimension photography
(VECTRA 3D, Canfield) before and after treatments (0 day, 6
weeks, and 6 months). Both patient and physician investigator
evaluated the treatment using a grading scale of improvement
ranging from I (no), II (less than 25%), III (26–50%), IV (51–75%),
and V (76–100%). Only grades IV and V were considered
satisfactory.
Results: The mode of propagation of mechanical waves generated
is called shear waves. The shear waves histological damages the
membrane of fat cells and causes disruption of that, damaging
also the septa of the fat layer with no epidermal and dermal
damage. The mean patients rate of satisfaction with a grade IV
and V was 70%. No side effects were related to the treatment only
5% of transitory redness and 10% of purpura.
Conclusion: The treatment sessions with non-invasive selective
ultrasound produce fat remodeling and sculping the face with
efficiency and safety. Based on this good result, others protocols
should be encouraged in view of the results are maintained over
time.
#239
THE NEW FASHION WAY TO IMPROVE THE
APPEARANCE OF CELLULITE USING THE
COMBINATION OF NON-INVASIVE SELECTIVE
ULTRASOUND (ACCENT ULTRA) WITH IN
MOTION UNIPOLAR RADIOFREQUENCY
(ACCENT UNIFORM)
Elaine Marques, Guilherme Alemida,
Leticia Almeida, Rachel Queiroz
Hospital Sirio Libanes, Sao Paulo, Brazil
Background: Cellulite affects 85–98% of post-pubertal females.
The aim of this paper is to present a new fashion way to improve
the appearance of cellulite using the combination of non-invasive
selective ultrasound (ACCENT ULTRA, Alma Lasers) and
radiofrequency (ACCENT UNIFORM).
Study: Thirty female patients with the diagnosis of cellulite on
the buttocks were treated. The sessions with uniform were weekly
during 10 weeks using the same parameters of 190 W and
accumulating 100 kJ each buttocks. The sessions with ultra were
separated by 14 days apart in a total of five treatments using the